Results 231 to 240 of about 163,448 (315)

Comprehensive analysis of the biological functions and prognostic significance of GDI1 in breast cancer. [PDF]

Medicine (Baltimore)
Yang Z, Zhang H, Wang N, Zhang Y.
europepmc   +1 more source

Fn14 signalling participates in pristane‐induced murine lupus through exacerbating oxidative stress

British Journal of Pharmacology, EarlyView.
Background and Purpose Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by oxidative stress and immune dysregulation. Fibroblast growth factor‐inducible 14 (Fn14) has been implicated in tissue injury, but its specific role in SLE pathogenesis remains unclear.
Zhu Yan, Rongfang Feng, Mai Luo, Yaqi Wang, Min Gao, Qin Chen, Yufei Zhang, Yale Liu, Yumin Xia   +8 more
wiley   +1 more source

Spermidine biosynthesis by hypervirulent <i>Francisella tularensis</i> promotes fitness and salvages adenine. [PDF]

J Bacteriol
Yue Y, Shinde D, Moore R, Yu Y, Thomas VC, Helikar T, Larson MA.   +6 more
europepmc   +1 more source

Biosynthesis of Guanosine Diphosphate d-Rhamnose and Guanosine Diphosphate d-Talomethylose from Guanosine Diphosphate α-d-Mannose

Journal of Biological Chemistry, 1964
openaire   +2 more sources

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, EarlyView.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Scarless Genetic Engineering of <i>Saccharomyces cerevisiae</i> for Enhanced Guanosine Monophosphate Production as a Natural Flavor Enhancer. [PDF]

J Microbiol Biotechnol
Jung SC, Oh H, Eom W, Jin YS, Park SH, Park K, Koh HG.   +6 more
europepmc   +1 more source

Hydrogen Bonding and Reactivity Behavior of Guanosine-5′ -Diphosphate from DFT and Molecular Docking Approach

Manoj Kumar Chaudhary, B. Maharjan, Gulab Singh Verma, Rajesh Shukla   +3 more
openalex   +2 more sources

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Determining the Importance of the Stringent Response for Methicillin-Resistant Staphylococcus aureus Virulence In Vivo. [PDF]

J Infect Dis
Choudhury NR, Urwin L, Salamaga B, Prince LR, Renshaw SA, Corrigan RM.   +5 more
europepmc   +1 more source

Irradiated Liver Cancer Cell Vaccine Transfected With GM‐CSF Induces Specific and Long‐Lasting Anti‐tumour Immunity Through the Synergistic Effect of Oxidised mtDNA and GM‐CSF

Cell Proliferation, EarlyView.
Song et al. developed an mGM‐CSF‐loaded, liver cancer cell‐based vaccine that potently activated dendritic cells and elicited tumour‐specific T cell responses. Mechanistically, radiation‐induced oxidative damage to mitochondrial DNA in cancer cells triggers the cGAS‐STING pathway in DCs, which synergizes with mGM‐CSF‐driven JAK2‐STAT3 signalling to ...
Zhiruo Song, Yujie Jiang, Yu Zhang, Danyi Ao, Chunjun Ye, Xiya Huang, Yingqiong Zhou, Hanle Yang, Ruolan Xia, Jiayuan Ai, Dandan Wan, Aiping Tong, Yuquan Wei, Xuemei He, Aqu Alu, Xiawei Wei   +15 more
wiley   +1 more source