British Journal of Pharmacology, EarlyView.Abstract Background and purpose Thiopurines are used in paediatric inflammatory bowel disease (IBD), but some patients do not respond. Because the gut microbiota influences drug efficacy and IBD‐patient microbiota presents increased bacterial abundance, we investigated the impact of candidate Enterobacteriaceae on drug cytotoxicity, metabolism and ...
Martina Franzin +13 more
wiley +1 more source
Molecular insights into de novo small-molecule recognition by an intron RNA structure. [PDF]
Proc Natl Acad Sci U S ALiu T +7 more
europepmc +1 more source
Loss-of-function coding variants in the Ras of complex proteins/GTPase domain of leucine rich repeat kinase 2. [PDF]
Protein SciAbstract The LRRK2 gene is a key contributor to the genetic risk of Parkinson's disease, and a priority drug target for the disorder. Leucine Rich Repeat Kinase 2, the protein product of LRRK2, is a multidomain enzyme implicated in a range of cellular processes—including endolysosomal trafficking and damage response. Based on the report that truncation
Butterfield S, Herbst S, Lewis PA.
europepmc +2 more sources
Isolation of cyclic 3',5'-guanosine monophosphate from bacterial culture fluids.
, 1975 Jiro Ishiyama
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Protein Initiation in Eukaryotes: Formation and Function of a Ternary Complex Composed of a Partially Purified Ribosomal Factor, Methionyl Transfer RNA f , and Guanosine Triphosphate [PDF]
, 1973 Daniel H. Levin, David Kyner, George Acs
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Assessment of hypervolemia by cyclic 3 ` 5 `-guanosine monophosphate in pediatric patients on hemodialysis [PDF]
, 1999 Gerzer, Rupert +6 more
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Role of the RAB27/SYTL Axis in Tumor Microenvironment Construction
Cancer Science, EarlyView.This review focuses on the role of the RAB27/SYTL axis in various cancer types associated with tumor microenvironment modifications. The importance of this pathway and the potential therapeutic strategies targeting vesicle production for the treatment of cancer are also discussed.
Miwa Tanaka, Takuro Nakamura
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Association of GCH1 polymorphism with Parkinson disease susceptibility: A meta-analysis. [PDF]
Medicine (Baltimore)Wang J, Shao F, Lin H, Zhan S, Wang J.
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ANP-ing Up Diabetes: Impaired Natriuretic Peptide Action in Muscle Forms a Mechanistic Link Between Obesity and Diabetes [PDF]
, 2015 Cleasby, M E
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Cell Proliferation, EarlyView.GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai +13 more
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