Results 261 to 270 of about 201,939 (380)

The Guanosine-Adenosine Interaction Exists In Vivo

Journal of Pharmacology and Experimental Therapeutics, 2014
E. Jackson, Z. Mi
semanticscholar   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Purine nucleoside phosphorylase dominates Influenza A virus replication and host hyperinflammation through purine salvage. [PDF]

Signal Transduct Target Ther
Yue Y, Li Q, Chen C, Yang J, Song W, Zhou C, Cui Y, Wei Z, He Q, Wang C, Lin H, Li J, Li J, Xi J, Song X, Yang W, Zhang Z, Shu W, Guo L, Wang S.   +19 more
europepmc   +1 more source

Role of Muscarinic Cholinergic Receptors in Regulation of Guanosine 3′:5′-Cyclic Monophosphate Content in Mammalian Brain, Heart Muscle, and Intestinal Smooth Muscle

, 1972
Tee-Ping Lee, J.F. Kuo, Paul Greengard
openalex   +1 more source

A steric gate prevents mutagenic dATP incorporation opposite 8‐oxo‐deoxyguanosine in mitochondrial DNA polymerases

The FEBS Journal, EarlyView.
Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres, Carlos H. Trasviña‐Arenas, Alexandru Ionut Gilea, Upeksha C. Dissanayake, Missael Molina‐Jiménez, Paola L. García‐Medel, Corina Díaz‐Quezada, Tiziana Lodi, G. Andrés Cisneros, Enrico Baruffini, Luis G. Brieba   +10 more
wiley   +1 more source

Discovery of reversing enzymes for RNA ADP-ribosylation reveals a possible defence module against toxic attack. [PDF]

Nucleic Acids Res
Lu Y, Schuller M, Bullen NP, Mikolcevic P, Zonjic I, Raggiaschi R, Mikoc A, Whitney JC, Ahel I.   +8 more
europepmc   +1 more source

Activation of guanylate cyclase by superoxide dismutase and hydroxyl radical: a physiological regulator of guanosine 3',5'-monophosphate formation.

, 1977
Chandra K. Mittal, Ferid Murad
openalex   +1 more source

Transforming mutations of RAC guanosine triphosphatases in human cancers

Proceedings of the National Academy of Sciences of the United States of America, 2013
Masahito Kawazu, Toshihide Ueno, K. Kontani, Yoshitaka Ogita, Mizuo Ando, Kazutaka Fukumura, Azusa Yamato, M. Soda, K. Takeuchi, Y. Miki, Hiroyuki Yamaguchi, T. Yasuda, T. Naoe, Y. Yamashita, T. Katada, Y. L. Choi, H. Mano   +16 more
semanticscholar   +1 more source

Realizing the promise of ‘La Dolce Vita’ via chemical biology: glycan‐motif editing of sLeX for precision cancer therapeutics

The FEBS Journal, EarlyView.
Modification of the glycocalyx via ‘glycan editing’ is distinguishable from ‘glycan‐motif editing’. The former broadly remodels the glycocalyx, whereas the latter inhibits expression only of a specific oligosaccharide motif within the glycocalyx by selectively dampening the bioactivity of the key glycosyltransferase(s) programming the biosynthesis of ...
Barbara Richichi, Robert Sackstein
wiley   +1 more source

Self-Regulating Hydrogel with Reversible Optical Activity in Its Gel-to-Gel Transformation. [PDF]

J Am Chem Soc
Li J, Yin F, Wang J, Du H, Xu F, Meskers S, Li Y, Wijker S, Peng Y, Bellan R, Vantomme G, Song J, Liu CS, Meijer EW.   +13 more
europepmc   +1 more source