Results 261 to 270 of about 238,540 (308)

Soluble guanylate cyclase induces cranial vasodilation and headache in adults: a randomized trial. [PDF]

Brain Commun
Rasmussen NB, Christensen CE, Ashina H, Amin FM, Domínguez-Moreno R, Abdulla J, Carlsen J, Ashina M.   +7 more
europepmc   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, EarlyView.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Comparative Binding Affinities of Platinum-Based Drugs toward Purine Alkaloids and Nucleobases. [PDF]

ACS Omega
Szefler B, Szupryczyński K.
europepmc   +1 more source

Decoding the Role of Caveolin‐1 in Morphological Diversity and Self‐Renewal of Breast Cancer Cells

Cell Proliferation, EarlyView.
The silence of caveolin‐1 (Cav‐1) reproduced the morphological evolutionary behaviour of cancer cells, which is similar to the epithelial‐mesenchymal transition process. And Cav‐1 dependent morphological changes could affect cancer cell self‐renewal capacity through maintaining the morphological stability.
Shun Li, Hongyun Duan, Lu Yang, Lingyi Jiang, Haocheng Bian, Yuqin Jiang, Yixi Zhang, Wei Yan, Qin Yang, Tingting Li, Xiang Qin, Zong‐Yuan Liu, Ningwei Sun, Kai‐fu Yang, Yiyao Liu   +14 more
wiley   +1 more source

Methylglyoxal-induced RNA modifications decrease RNA stability and translation and are associated with type 2 diabetes. [PDF]

Mol Metab
Lopez Gonzalez EJ, Lai S, Sun K, Carson CR, Hernandez-Castillo C, Zoukari T, Lopez K, Zhang J, Blevins T, Termini J, Shuck SC.   +10 more
europepmc   +1 more source

A UK key opinion leader perspective: Navigating the immunological and logistical transformation brought by stem cell‐derived islets for the treatment of type 1 diabetes

Diabetic Medicine, EarlyView.
Abstract Aims To explore UK key‐opinion leader perspectives on the future role of stem cell‐derived islets (sc‐islets) in islet transplantation for people with type 1 diabetes (T1D). Methods Four UK‐based key‐opinion leaders evaluated current limitations of donor islet transplantation and reviewed emerging evidence, clinical pathways and logistical ...
Thomas Strakosch, Shareen Forbes
wiley   +1 more source

Pentose bisphosphate pathway can act in central metabolism for nucleoside-dependent growth of <i>Thermococcus kodakarensis</i> strains. [PDF]

Appl Environ Microbiol
Nishida T, Chen Y, Azuma T, Orita I, Fukui T.   +4 more
europepmc   +1 more source

Taxonomic and functional shifts in the microbiome of severely obese, prediabetic patients: Ketogenic diet versus energy‐matched standard diet

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Obesity and type 2 diabetes mellitus (T2DM) are among the leading global health challenges of the 21st century. While caloric restriction remains the cornerstone of weight loss interventions, ketogenic diets (KD), characterised by low carbohydrate and high fat intake, have been shown to improve metabolic health partly by modulating the ...
June Stone, Afroditi Tripyla, Melanie C. Scalise, Maria L. Balmer, Lia Bally, Dominik M. Meinel   +5 more
wiley   +1 more source

Crystal structures reveal the distinct features of the 2'-dG-III riboswitch in the purine riboswitch family. [PDF]

Nucleic Acids Res
Chen K, Liao W, Wang J, Ren Y, Lu Z, Peng X, Wang J, Huang L.   +7 more
europepmc   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source