Results 261 to 270 of about 201,939 (380)

The Guanosine-Adenosine Interaction Exists In Vivo

open access: yesJournal of Pharmacology and Experimental Therapeutics, 2014
E. Jackson, Z. Mi
semanticscholar   +1 more source

PI5P4K inhibitors: promising opportunities and challenges

open access: yesThe FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi   +16 more
wiley   +1 more source

Purine nucleoside phosphorylase dominates Influenza A virus replication and host hyperinflammation through purine salvage. [PDF]

open access: yesSignal Transduct Target Ther
Yue Y   +19 more
europepmc   +1 more source

A steric gate prevents mutagenic dATP incorporation opposite 8‐oxo‐deoxyguanosine in mitochondrial DNA polymerases

open access: yesThe FEBS Journal, EarlyView.
Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres   +10 more
wiley   +1 more source

Discovery of reversing enzymes for RNA ADP-ribosylation reveals a possible defence module against toxic attack. [PDF]

open access: yesNucleic Acids Res
Lu Y   +8 more
europepmc   +1 more source

Transforming mutations of RAC guanosine triphosphatases in human cancers

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2013
Masahito Kawazu   +16 more
semanticscholar   +1 more source

Realizing the promise of ‘La Dolce Vita’ via chemical biology: glycan‐motif editing of sLeX for precision cancer therapeutics

open access: yesThe FEBS Journal, EarlyView.
Modification of the glycocalyx via ‘glycan editing’ is distinguishable from ‘glycan‐motif editing’. The former broadly remodels the glycocalyx, whereas the latter inhibits expression only of a specific oligosaccharide motif within the glycocalyx by selectively dampening the bioactivity of the key glycosyltransferase(s) programming the biosynthesis of ...
Barbara Richichi, Robert Sackstein
wiley   +1 more source

Self-Regulating Hydrogel with Reversible Optical Activity in Its Gel-to-Gel Transformation. [PDF]

open access: yesJ Am Chem Soc
Li J   +13 more
europepmc   +1 more source

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