Salvage enzymes in nucleotide biosynthesis [PDF]
, 2007 Balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA, and ribonucleoside triphosphates (NTPs), the precursors of RNA, are crucial for a controlled cell proliferation.
Kosinska, Urszula
core
Selective [9‐15N] Guanosine for NMR Studies of Large RNAs
ChemBioChem, Accepted Article.RNAs regulate various cellular processes using malleable 3D structures, and understanding the factors that control RNA structure and dynamics is critical for understanding their mechanisms of action. To mitigate factors that have limited studies of large, functionally relevant RNAs by solution NMR spectroscopy, we have extended a recently described 2H ...
Solomon K. Attionu +5 more
wiley +1 more source
A Long Overdue Targeted Treatment for KRAS Mutations in NSCLC: Spotlight on Adagrasib
Lung Cancer: Targets and Therapy, 2022 Danielle Brazel,1 Zhaohui Arter,1 Misako Nagasaka1– 3 1Department of Medicine, University of California Irvine School of Medicine, Orange, CA, USA; 2Chao Family Comprehensive Cancer Center, Orange, CA, USA; 3St.
Brazel D, Arter Z, Nagasaka M
doaj
Suppression of the biosynthesis of guanosine triphosphate by protein synthesis inhibitors.
Journal of Biological Chemistry, 1980 In a prior report (Pike, L.M., Khym, J.X., Jones, M.H., Lee, W.H., and Volkin, E. (1980) J. Biol. Chem. 255, 3340-3347), it was observed that CTP synthesis and concomitant incorporation of CMP into RNA and dCMP into DNA were markedly reduced in cells cultured in the presence of cycloheximide and puromycin.
M H Jones +4 more
openaire +3 more sources
Characterisation of ERK distribution and activity in rat pheochromocytoma cells : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Molecular Biology at Massey University [PDF]
, 1998 Nerve growth factor (NGF) binds to the NGF receptor, TrkA, at the tips of nerve cell axons, sending a signal that prevents programmed cell death and causes survival, growth, and differentiation of the nerve cell.
MacCormick, Matthew Edgar
core
Tailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling. [PDF]
, 2014 Heart failure is one of the leading causes of mortality in Western countries, and β-blockers are a cornerstone of its treatment. However, the response to these drugs is variable among individuals, which might be explained, at least in part, by genetic ...
Barrese, V +3 more
core +2 more sources
Light‐Responsive Mononucleotide Coacervates
Chemistry – A European Journal, EarlyView.Light‐responsive mononucleotide coacervates undergo reversible phase transitions via azobenzene photoisomerization. Coacervates with high‐valency azobenzenes remain stable under UV light, while those with low‐valency azobenzenes dissolve, enabling nucleotide release. This minimal system highlights the potential role of light for exploring energy‐driven
Edison Rafael Jimenez Granda +4 more
wiley +1 more source
Shear-Induced Nitric Oxide Production by Endothelial Cells [PDF]
, 2016 We present a biochemical model of the wall shear stress (WSS)-induced activation of endothelial nitric oxide synthase (eNOS) in an endothelial cell (EC). The model includes three key mechanotransducers: mechanosensing ion channels, integrins and G-protein-coupled receptors. The reaction cascade consists of two interconnected parts.
arxiv +1 more source
Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells. [PDF]
, 2015 The treatment of myocardial infarction is a major challenge in medicine due to the inability of heart tissue to regenerate. Direct reprogramming of endogenous cardiac fibroblasts into functional cardiomyocytes via the delivery of transcription factor ...
Kim, Hyun Jin +5 more
core +3 more sources
Clinical Pharmacology in Drug Development, EarlyView.Abstract A combination of nucleotide hepatitis C virus (HCV) nonstructural protein (NS) 5B and 5A inhibitors is a preferred standard of care for treating chronic HCV. Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against HCV NS5B.
Xiao‐Jian Zhou +7 more
wiley +1 more source