Journal of Biological Chemistry, 1966 Abstract The rabbit reticulocyte is capable of utilizing purines and their ribosyl derivatives for nucleoside triphosphate formation. Adenine, adenosine, hypoxanthine, and inosine are used extensively for the synthesis of adenosine triphosphate. Xanthine, guanine, and guanosine are utilized primarily for the synthesis of guanosine triphosphate.
J L, Cook, M, Vibert
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Movement Disorders, EarlyView.Abstract Background SUNRISE‐PD was a dose‐escalating, phase 1/2 study investigating a second‐generation lentiviral vector gene therapy delivering the genes for dopamine synthesis (OXB‐102) to treat Parkinson's disease (PD). The trial was prematurely terminated due to insolvency of the sponsor.
Simon Rowe +19 more
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Post-Translational Modification and Subcellular Distribution of Rac1: An Update
Cells, 2018 Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of cellular effects, including regulation of cytoarchitecture, cell size, cell ...
Abdalla Abdrabou, Zhixiang Wang
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Chemoattractant and guanosine 5′-[γ-thio]triphosphate induce the accumulation of inositol 1,4,5-trisphosphate in Dictyostelium cells that are labelled with [3H]inositol by electroporation [PDF]
, 1989 Peter J.M. Van Haastert +6 more
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Ferroptosis and Its Emerging Role in Gestational Diabetes Mellitus
Medicine Advances, EarlyView.Ferroptosis contributes to the development of gestational diabetes mellitus (GDM) through iron overload, lipid peroxidation, and antioxidant system disruption. These changes impair adipocyte and β‐cell function, promoting insulin resistance and hyperglycemia.
Jinfeng Xu +4 more
wiley +1 more source
Molecular Therapy: Methods & Clinical Development, 2019 We developed a novel chemically modified miR-143 (miR-143#12), and with it we investigated the contribution of miR-143 to the pathogenesis of bladder cancer (BC), in which miR-143 is extremely downregulated.
Yuki Yoshikawa +11 more
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Interactions between a lymphoma membrane-associated guanosine 5'-triphosphate-binding protein and the cytoskeleton during receptor patching and capping. [PDF]
, 1990 Lilly Bourguignon +2 more
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Phytochemical Analysis, EarlyView.ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek +3 more
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Kinetic and Structural Analysis of the Mg2+ -binding Site of the Guanine Nucleotide-binding Protein p21 H-ras. [PDF]
, 1993 The coordination and binding of the Mg2+ ion in the nucleotide−binding site of p21 have been investigated using site−directed mutagenesis, kinetic methods, and phosphorous NMR.
Borasio, Gian Domenico +6 more
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Effects of insulin and guanosine 5′-[γ-thio]triphosphate on fatty acid synthesis and lipolysis within electropermeabilized fat-cells [PDF]
, 1992 Guy A. Rutter, Richard M. Denton
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