Results 141 to 150 of about 73,799 (301)

Medial septum parvalbumin‐expressing inhibitory neurons are impaired in a mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is a severe neurodevelopmental disorder caused by pathogenic variants in the SCN1A gene, which encodes the voltage‐gated sodium channel Nav1.1 α subunit. Experiments in animal models of DS—including the haploinsufficient Scn1a+/− mouse—have identified impaired excitability of interneurons in the hippocampus and ...
Limei Zhu, Yiannos Demetriou, Joseph Barden, Juan Disla, Meiling Zhao, Joanna Mattis   +5 more
wiley   +1 more source

Periodontitis and Platelets Status: A Systematic Review With Meta‐Analysis and Trial Sequential Analysis

Journal of Periodontal Research, EarlyView.
The certainty is moderate for a slightly higher platelet count in patients with periodontitis compared to individuals without periodontitis and low for no difference in mean platelet volume between the two groups. The evidence is not robust to claim a clear difference in other platelet activation biomarkers between the two groups.
Dimitris Sokos, Marja L. Laine, Elena A. Nicu, Kelly Hiu Lam Chung, Ni‐ni Dong Qing Sluijk, Dagmar Else Slot, Sergio Bizzarro   +6 more
wiley   +1 more source

Staphylococcus aureus COL: An Atypical Model Strain of MRSA That Exhibits Slow Growth and Antibiotic Tolerance due to a Mutation in PRPP Synthetase

Molecular Microbiology, EarlyView.
COL is an unusual “model” strain of Staphylococcus aureus that exhibits slow growth and multidrug antibiotic tolerance. This phenotype is primarily due to a mutation in Prs, which synthesizes the core metabolite phosphoribosyl pyrophosphate (PRPP). Introduction of the COL Prs allele into the antibiotic‐susceptible strain Newman confers tolerance, while
Claire E. Stevens, Ashley T. Deventer, Paul R. Johnston, Phillip T. Lowe, Alisdair B. Boraston, Joanne K. Hobbs   +5 more
wiley   +1 more source

A Comparison on the Coordination Tendency towards Cu²⁺ of the Base Moieties in Guanosine, Inosine and Adenosine 5′‐Triphosphates [PDF]

, 1974
Helmut Sigel, Christoph F. Naumann, Bernhard PRUS   +2 more
openalex   +1 more source

In vitro quality of whole blood‐derived red cell concentrates collected, processed and stored in a blood bag set plasticized with di (2‐ethylhexyl) terephthalate

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Due to toxicity concerns, di(2‐ethylhexyl) phthalate (DEHP)—the most used plasticizer in polyvinyl chloride (PVC) whole blood (WB) collection and processing bag sets—will be effectively prohibited in medical devices in Europe from 2030. Removal of DEHP will primarily impact the in vitro quality of red blood cell (RBC)
Tatiana Stephenson, Anita Howell, Carly Olafson, Chryslain Sumian, Stefan Reichenberg, Quentin Brebant, Ken McTaggart, Geraldine M. Walsh   +7 more
wiley   +1 more source

Derivatives of Guanosine Triphosphate with Ribose 2′‐Hydroxyl Substituents [PDF]

, 1976
Ernest Hamel
openalex   +1 more source

Genomic Characterisation of Limosilactobacillus fermentum CRL2085 Unveiling Probiotic Traits for Application in Cattle Feed

Environmental Microbiology Reports, Volume 17, Issue 5, October 2025.
A comprehensive genomic and phenotypic analysis of Limosilactobacillus fermentum CRL2085 revealed key probiotic and nutritional traits supporting its safe application in cattle feed. The strain harbors genes for stress tolerance, adhesion, exopolysaccharide production, and B‐vitamin biosynthesis, and efficiently metabolizes plant‐derived carbohydrates,
Cecilia M. Aristimuño Ficoseco, Daniele Chieffi, Marco Montemurro, Annarita Bavaro, Carlo G. Rizzello, Maria E. F. Nader‐Macias, Silvina Fadda, Francesca Fanelli, Vincenzina Fusco, Graciela M. Vignolo   +9 more
wiley   +1 more source

Bovine Liver Glutamate Dehydrogenase: Tentative Amino Acid Sequence; Identification of a Reactive Lysine; Nitration of a Specific Tyrosine and Loss of Allosteric Inhibition by Guanosine Triphosphate [PDF]

, 1970
Emil L. Smith, Michael Landon, Dennis Piszkiewicz, William J. Brattin, Trevor J. Langley, M.D. Melamed   +5 more
openalex   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, Volume 14, Issue 23, September 8, 2025.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Amylase release from streptolysin O-permeabilized pancreatic acinar cells. Effects of Ca2+, guanosine 5'-[gamma-thio]triphosphate, cyclic AMP, tetanus toxin and botulinum A toxin [PDF]

, 1992
The molecular requirements for amylase release and the intracellular effects of botulinum A toxin and tetanus toxin on amylase release were investigated using rat pancreatic acinar cells permeabilized with streptolysin O.
Ahnert-Hilger, G., Gratzl, Manfred, Kemmer, T. P., Stecher, B., Weller, U.   +4 more
core