Results 141 to 150 of about 177,246 (350)

Delineation of molecular interactions of plant growth promoting bacteria induced β-1,3-glucanases and guanosine triphosphate ligand for antifungal response in rice: a molecular dynamics approach. [PDF]

Mol Biol Rep, 2022
Jha Y, Dehury B, Kumar SPJ, Chaurasia A, Singh UB, Yadav MK, Angadi UB, Ranjan R, Tripathy M, Subramanian RB, Kumar S, Simal-Gandara J.   +11 more
europepmc   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Conformations and binding pockets of HRas and its guanine nucleotide exchange factors complexes in the guanosine triphosphate exchange process. [PDF]

J Comput Chem, 2022
Xiong Y, Zeng J, Xia F, Cui Q, Deng X, Xu X.   +5 more
europepmc   +1 more source

Derivatives of Guanosine Triphosphate with Ribose 2′‐Hydroxyl Substituents [PDF]

, 1976
Ernest Hamel
openalex   +1 more source

IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope

Cancer Science, EarlyView.
This review provides a systematic summary of the current understanding of IMPDH biology, emphasizing its complex regulation and therapeutic relevance in cancer. We will outline key unresolved questions, including isozyme‐specific roles and mechanisms for escaping regulations, and propose mechanistic and translational strategies to design IMPDH‐targeted
Aki Ogawa‐Iio, Koh Takeuchi, Keita Shigemi, Michelle Jane Genoveso, Hiroaki Niitsu, Iemasa Koh, Yusei Ota, Keita Yamane, Takao Hinoi, Natsuki Osaka, Masashi Oshima, Tomohiro Ishikawa, Tomoyuki Mizuno, Manabu Natsumeda, Kensuke Tateishi, Rintaro Hashizume, Satoru Osuka, Susumu Goyama, Tomoharu Yasuda, Toshiya Senda, Atsuo T. Sasaki   +20 more
wiley   +1 more source

Mechanism of Guanosine Triphosphate Hydrolysis by the Visual Proteins Arl3-RP2: Free Energy Reaction Profiles Computed with Ab Initio Type QM/MM Potentials. [PDF]

Molecules, 2021
Khrenova MG, Bulavko ES, Mulashkin FD, Nemukhin AV.   +3 more
europepmc   +1 more source

Protein Initiation in Eukaryotes: Formation and Function of a Ternary Complex Composed of a Partially Purified Ribosomal Factor, Methionyl Transfer RNA _f , and Guanosine Triphosphate [PDF]

, 1973
Daniel H. Levin, David Kyner, George Acs
openalex   +1 more source

Reaction of Guanosine Triphosphate and Uridine Triphosphate with Actomyosin Gel [PDF]

Acta Chemica Scandinavica, 1954
Rolf Bergkvist, G. Hevesy, Paavo Pääkkönen, Adam Deutsch, Oiva Järvelä   +4 more
openaire   +2 more sources

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

Cell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai, Jialei Hua, Donghua Meng, Yue Xu, Benfu Zhong, Miao Liu, Zhaosong Wang, Wei Zhou, Liming Liu, Hailong Wang, Yang Liu, Lifang Li, Xiuju Chen, Yueguo Li   +13 more
wiley   +1 more source

A phased-addition strategy enhances the yield of RNAs obtained by in vitro transcription with modified transcriptional initiators [PDF]

, 2015
RNA is active in multiple biological processes, not only as an information carrier but in catalyzing reactions and regulating gene expression. To understand the basis for this versatility, it is critical to establish structure-function relationships in ...
Adib, Katie
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