Rapid oxygen release from stored red blood cells can be preserved for longer with refined additive solutions. [PDF]
TransfusionAbstract Background Stored red blood cells (RBCs) progressively lose metabolic and structural features that are critical for efficient oxygen release, potentially reducing transfusion efficacy. Compared to the standard storage additive saline‐adenine‐glucose‐mannitol (SAGM), successive refinements such as phosphate‐adenine‐glucose‐guanosine‐saline ...
Rabcuka J +8 more
europepmc +2 more sources
Food Frontiers, Volume 7, Issue 1, January 2026.Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli +8 more
wiley +1 more source
The Iron-Type Nitrile Hydratase Activator Protein Is A GTPase [PDF]
, 2017 The Fe-type nitrile hydratase activator protein from Rhodococcus equi TG328-2 (ReNHase TG328-2) was successfully expressed and purified. Sequence analysis and homology modeling suggest that it is a G3E P-loop guanosine triphosphatase (GTPase) within the ...
Bennett, Brian +3 more
core +1 more source
Differential Expression of the Adenylyl Cyclase-Stimulatory Guanosine Triphosphate-Binding Protein Gsα in the Human Myometrium during Pregnancy and Labor Involves Transcriptional Regulation by Cyclic Adenosine 3′,5′-Monophosphate and Binding of Phosphorylated Nuclear Proteins to Multiple GC Boxes within the Promoter [PDF]
, 2002 Robert Phillips +3 more
openalex +1 more source
The Role of Macrophages in Cancer: From Basic Research to Clinical Applications
MedComm, Volume 7, Issue 1, January 2026.Monocytes infiltrate the tumor microenvironment (TME) and differentiate into macrophages, which polarize into proinflammatory, antitumor M1 cells or immunosuppressive, protumor M2 cells. Within the TME, M2‐type tumor‐associated macrophages (TAMs) predominate and drive tumor growth, angiogenesis, and metastasis. Therapeutic strategies therefore focus on
Zhimei Liu +5 more
wiley +1 more source
Drug Design, Development and Therapy, 2013 Giovanni M Pitari Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA, USA Abstract: Agonists of the transmembrane intestinal receptor guanylyl cyclase C (GCC) have recently attracted interest as ...
Pitari GM
doaj
Association of NGF receptors with membrane rafts in PC12 cells : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]
, 2001 Nerve Growth Factor (NGF) signal transduction is involved in the survival, differentiation and maintenance of neurons through the receptors TrkA and p75NTR. These receptors activate downstream protein kinase cascades that regulate cell survival.
Clements, Shona Marie
core
Protein Science, Volume 35, Issue 1, January 2026.Abstract Human RNA capping is critical for mRNA splicing, protection of RNA from 5′ exonucleases in the cytoplasm, and targeting to the ribosome. Human RNMT, CMTR1, and CMTR2 are RNA methyltransferases involved in the RNA capping process. They play a significant role in the proliferation and differentiation of embryonic stem cells and have been ...
Fatemeh Taherian +7 more
wiley +1 more source