Frontiers in Pharmacology, 2018 The extracellular guanosine 5′-triphosphate, GTP, has been demonstrated to be an enhancer of myogenic cell differentiation in a murine cell line, not yet in human muscle cells.
Tiziana Pietrangelo +9 more
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Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer. [PDF]
J Clin Invest, 2021 MYC stimulates both metabolism and protein synthesis, but it is unknown how cells coordinate these complementary programs. Previous work reported that in a subset of small cell lung cancer (SCLC) cell lines, MYC activates guanosine triphosphate (GTP ...
Huang F +27 more
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Microtubules grow by the addition of bent guanosine triphosphate tubulin to the tips of curved protofilaments. [PDF]
J Cell Biol, 2018 We used electron tomography to examine microtubules (MTs) growing from pure tubulin in vitro as well as two classes of MTs growing in cells from six species.
McIntosh JR +6 more
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Spectrum of neurodevelopmental disease associated with the GNAO1 guanosine triphosphate-binding region. [PDF]
Epilepsia, 2019 To characterize the phenotypic spectrum associated with GNAO1 variants and establish genotype‐protein structure‐phenotype relationships.
Kelly M +23 more
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Evidence that guanosine triphosphate (GTP)-binding proteins control a synaptic response in brain: effect of pertussis toxin and GTP gamma S on the late inhibitory postsynaptic potential of hippocampal CA3 neurons [PDF]
Journal of Neuroscience, 1988 These experiments show that a synaptic response in brain, namely, the late inhibitory postsynaptic potential (IPSP) of hippocampal CA3 neurons in the rat hippocampal slice, was blocked by 2 compounds affecting guanosine triphosphate (GTP)-binding ...
R. H. Thalmann
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Bovine Liver Glutamate Dehydrogenase: Tentative Amino Acid Sequence; Identification of a Reactive Lysine; Nitration of a Specific Tyrosine and Loss of Allosteric Inhibition by Guanosine Triphosphate [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1970 A tentative but almost complete amino acid sequence for the subunit peptide chain of bovine liver glutamate dehydrogenase indicates a minimal size of 506 residues with a molecular weight of 56,100, in accord with the physical size of the subunit of 55 ...
Emil L. Smith +5 more
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Maintenance of endothelial guanosine triphosphate cyclohydrolase I ameliorates diabetic nephropathy.
J Am Soc Nephrol, 2013 In diabetes, endothelial nitric oxide synthase (eNOS) produces superoxide anion rather than nitric oxide, referred to as "eNOS uncoupling," which may contribute to endothelial dysfunction, albuminuria, and diabetic nephropathy.
Kidokoro K +5 more
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Biophysica, 2023 We report the results of computational studies of the guanosine triphosphate (GTP) hydrolysis in the active site of the KRas-NF1 protein complex, where KRas stands for the K-isoform of the Ras (ras sarcoma) protein and NF1 (neurofbromin-1) is the ...
Igor Polyakov, Alexander Nemukhin
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Human granulocyte colony-stimulating factor specifically binds to murine myeloblastic NFS-60 cells and activates their guanosine triphosphate binding proteins/adenylate cyclase system [PDF]
Blood, 1989 The specific binding of human granulocyte colony-stimulating factor (G-CSF) to its receptors on NFS-60 cells acts as a primer for cellular proliferation.
Sachiko Matsuda +2 more
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