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Controlling Supramolecular Fiber Formation of Nucleopeptide by Guanosine Triphosphate
Biomacromolecules, 2023Cells use dynamic self-assembly to construct functional structures for maintaining cellular homeostasis. However, using a natural biological small molecule to mimic this phenomenon remains challenging. This work reports the dynamic microfiber formation of nucleopeptide driven by guanosine triphosphate, the small molecule that controls microtubule ...
Hongyue Zhang +7 more
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Synthesis of Guanosine-Containing Dinucleoside Triphosphates
Advanced Materials Research, 2014Dinucleoside polyphosphates have potential medicinal value and are of substantial interest to both synthetic and medicinal chemists. A practical method for the synthesis of guanosine-containing asymmetrical dinucleoside triphosphates (Gp3C and Gp3U) with 4,5-dicyanoimidazole as activator has been developed.
Yue Hai You, Shan Shan Gong, Qi Sun
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Interactions of tubulin with vinblastine and guanosine triphosphate
Journal of Molecular Biology, 1972Abstract Tubulin isolated from calf brain contains one mole of tightly bound nucleotide per 120,000 g of protein, chiefly as GDP. Another mole of GTP can be bound in exchange with the medium. Transphosphorylation occurs between the terminal phosphate of the exchangeable nucleotide and the tightly bound GDP.
R W, Berry, M L, Shelanski
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[37] Guanosine triphosphate-8-formylhydrolase
1975Publisher Summary This chapter discusses the assay and purification procedure of guanosine triphosphate-8-formylhydrolase. The assay method is based on two procedures. The first method involves the release of 14 C-labeled formic acid from carbon-8 of the imidazole ring of [8- 14 C]GTP. The formic acid is oxidized to carbon dioxide. The second method
E.F. Elstner, R.J. Suhadolnik
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Analytical Biochemistry, 1989
A procedure for enzymatic production of dihydroneopterin triphosphate is described that allows GTP cyclohydrolase I to be reused repetitively. The reaction takes place in an ultrafiltration cell, and the product is collected in the filtrate, whereas the enzyme remains in the cell to be reused with additional substrate. This is repeated until the enzyme
J, Ferre, E W, Naylor, K B, Jacobson
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A procedure for enzymatic production of dihydroneopterin triphosphate is described that allows GTP cyclohydrolase I to be reused repetitively. The reaction takes place in an ultrafiltration cell, and the product is collected in the filtrate, whereas the enzyme remains in the cell to be reused with additional substrate. This is repeated until the enzyme
J, Ferre, E W, Naylor, K B, Jacobson
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Biochemistry, 1986
Using highly purified calf brain tubulin bearing [8-14C]guanosine 5'-diphosphate (GDP) in the exchangeable nucleotide site and heat-treated microtubule-associated proteins (both components containing negligible amounts of nucleoside diphosphate kinase and nonspecific phosphatase activities), we have found that a significant proportion of exchangeable ...
E, Hamel, J K, Batra, C M, Lin
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Using highly purified calf brain tubulin bearing [8-14C]guanosine 5'-diphosphate (GDP) in the exchangeable nucleotide site and heat-treated microtubule-associated proteins (both components containing negligible amounts of nucleoside diphosphate kinase and nonspecific phosphatase activities), we have found that a significant proportion of exchangeable ...
E, Hamel, J K, Batra, C M, Lin
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Neonatal hyperphenylalaninemia presumably caused by guanosine triphosphate-cyclohydrolase deficiency
The Journal of Pediatrics, 1985C'est la recherche systematique des pteridines dans les urines qui a permis de suspecter le deficit en GTP-cyclohydrolase, 1ere etape de la synthese de la tetrahydrobiopterine (BH 4 ) chez un bebe hyperphenylalaninemique (HPA). Le deficit en BH 4 , variante rare de l'HPA, differe de la PKU classique par le caractere evolutif de l'atteinte neurologique ...
J L, Dhondt +6 more
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Direct photoaffinity labeling of tubulin with guanosine 5'-triphosphate
Biochemistry, 1985Irradiation of tubulin in the presence of [3H]GTP or [3H]GDP at 254 nm led to the covalent incorporation of nucleotide into the protein. The specific nature of the labeling was shown in the following manner: with tubulin depleted of exchangeable nucleotide, the amount of labeling increased to a plateau value as the [3H]GTP concentration was increased ...
J P, Nath, G R, Eagle, R H, Himes
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Preparative method of obtaining guanosine 5′-triphosphate
Chemistry of Natural Compounds, 19651. The kinetics of the formation of guanosine 5′-triphosphate, 5′-diphosphate, and 5′-monophosphate in the reaction of the morpholide of guanosine 5′-monophosphate with bis-(tributylammonium) pyrophosphate in pyridine at 27° has been recorded. 2. In the reaction of the morpholide of guanosine 5′-monophosphate with bis-(tributylammonium) pyrophosphate ...
T. S. Lomakina, N. I. Grineva
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Adenosine Triphosphate and Guanosine Triphosphate Determinations in Intertidal Sediments
1979Measurements were made of the spatial distributions of adenosine triphosphate (ATP) on a variety of sandy beaches. Samples were collected during ebb flow and extracted in the field using cold sulfuric acid and ethylenediamine tetraacetate (EDTA); the neutralized extracts were immediately frozen for subsequent analyses.
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