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Interactions of tubulin with vinblastine and guanosine triphosphate
Journal of Molecular Biology, 1972Abstract Tubulin isolated from calf brain contains one mole of tightly bound nucleotide per 120,000 g of protein, chiefly as GDP. Another mole of GTP can be bound in exchange with the medium. Transphosphorylation occurs between the terminal phosphate of the exchangeable nucleotide and the tightly bound GDP.
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Biomacromolecules, 2023Cells use dynamic self-assembly to construct functional structures for maintaining cellular homeostasis. However, using a natural biological small molecule to mimic this phenomenon remains challenging. This work reports the dynamic microfiber formation of nucleopeptide driven by guanosine triphosphate, the small molecule that controls microtubule ...
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