The protein partners of GTP cyclohydrolase I in rat organs. [PDF]
PLoS ONE, 2012 GTP cyclohydrolase I (GCH1) is the rate-limiting enzyme for tetrahydrobiopterin biosynthesis and has been shown to be a promising therapeutic target in ischemic heart disease, hypertension, atherosclerosis and diabetes.
Jianhai Du +6 more
doaj +4 more sources
GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling [PDF]
ACS Central Science, 2019 Ferroptosis is an iron-dependent form of regulated cell death linking iron, lipid, and glutathione levels to degenerative processes and tumor suppression.
Vanessa A. N. Kraft +16 more
doaj +3 more sources
Identification and Functional Analysis of GTP Cyclohydrolase II in Candida glabrata in Response to Nitrosative Stress [PDF]
Frontiers in Microbiology, 2022 Reactive nitrogen species (RNS) are signal molecules involved in various biological events; however, excess levels of RNS cause nitrosative stress, leading to cell death and/or cellular dysfunction.
Ryo Nasuno +5 more
doaj +2 more sources
Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo [PDF]
Redox Biology, 2022 Background: s: Hyperhomocysteinemia (HHcy) is one of risk factors for vascular cognitive impairment (VCI). GTP cyclohydrolase 1 (GCH1) deficiency is critical to oxidative stress in vascular dysfunction.
Ya-Ling Yin +12 more
doaj +2 more sources
GTP-Cyclohydrolase I deficiency presenting as malignant hyperphenylalaninemia, recurrent hyperthermia and progressive neurological dysfunction in a South Asian child – a case report [PDF]
BMC Pediatrics, 2019 Background Tetrahydrobiopterin (BH4) deficiencies are disorders affecting phenylalanine homeostasis, and catecholamine and serotonin biosynthesis. GTP-Cyclohydrolase I deficiency (OMIM 600225) is an extremely rare variant of inborn error of BH4 synthesis
Kavinda Chandimal Dayasiri +6 more
doaj +2 more sources
Elevated GTP Cyclohydrolase I Pathway in Endothelial Progenitor Cells of Overweight Premenopausal Women [PDF]
Cardiology Research and Practice, 2020 Background/Aims. Sexual differences exist in endothelial progenitor cells (EPCs), and various cardiovascular risk factors are associated with the preservation of endothelial function in premenopausal women.
Shaohong Wu +9 more
doaj +2 more sources
Transgenic overexpression of GTP cyclohydrolase 1 in cardiomyocytes ameliorates post-infarction cardiac remodeling [PDF]
Scientific Reports, 2017 GTP cyclohydrolase 1 (GCH1) and its product tetrahydrobiopterin play crucial roles in cardiovascular health and disease, yet the exact regulation and role of GCH1 in adverse cardiac remodeling after myocardial infarction are still enigmatic.
Yanan Liu +10 more
doaj +2 more sources
Inhibition of Aberrant MicroRNA-133a Expression in Endothelial Cells by Statin Prevents Endothelial Dysfunction by Targeting GTP Cyclohydrolase 1 in Vivo [PDF]
Circulation, 2016 Mo-Li Zhu, Ping Xu, Yuan Chen
exaly +2 more sources
Dtorsin, the Drosophila ortholog of the early-onset dystonia TOR1A (DYT1), plays a novel role in dopamine metabolism. [PDF]
PLoS ONE, 2011 Dystonia represents the third most common movement disorder in humans. At least 15 genetic loci (DYT1-15) have been identified and some of these genes have been cloned.
Noriko Wakabayashi-Ito +6 more
doaj +1 more source
Assay for GTP Cyclohydrolase II Activity in Bacterial Extracts
Bio-Protocol, 2014 Riboflavin is the precursor of flavin nucleotides FMN and FAD, they play significant roles in all organisms. GTP is the initial precursor on riboflavin biosynthesis pathway and GTP cyclohydrolase II catalyzes the first step of this pathway.
Svetlana Yurgel +3 more
doaj +1 more source