Results 1 to 10 of about 14,507 (223)
Tetrahydrobiopterin and inherited hyperphenylalaninemias
The Turkish Journal of Pediatrics, 1996 Tetrahydrobiopterin deficiency, a variant of hyperphenylalaninemia, may be caused by deficiency of one of the following enzymes: guanosine triphosphate cyclohydrolase 1,6-pyruvoyltetrahydropterin synthase, dihydropteridin reductase and pterin-4a ...
N Blau, B Thony, M Spada, A Ponzone
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Tetrahydrobiopterin Deficiency: From Phenotype to Genotype [PDF]
Pteridines, 1993 As a result of the selective screening worldwide during the last 18 years, approximately 250 patients with tetrahydrobiopterin deficiency were discovered.
Blau Nenad +3 more
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Journal of Lipid Research, 2007 An assay was set up for glyceryl ether monooxygenase activity in tissue samples using the novel substrate 1-O-pyrenedecyl-sn-glycerol and high-performance liquid chromatographic analysis of reaction mixtures with fluorescence detection, allowing robust ...
Ernst R. Werner +4 more
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Expression of full-length human alkylglycerol monooxygenase and fragments in Escherichia coli
Pteridines, 2013 Alkylglycerol monooxygenase (AGMO; EC 1.14.16.5) is the only enzyme known to cleave the O-alkyl ether bond of alkylglycerols in humans. It is an integral membrane protein with nine predicted transmembrane domains.
Mayer Matthias +5 more
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The Emerging Physiological Role of AGMO 10 Years after Its Gene Identification
Life, 2021 The gene encoding alkylglycerol monooxygenase (AGMO) was assigned 10 years ago. So far, AGMO is the only known enzyme capable of catalysing the breakdown of alkylglycerols and lyso-alkylglycerophospholipids. With the knowledge of the genetic information,
Sabrina Sailer +3 more
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Insulin Stimulates Tetrahydrobiopterin Synthesis in Mouse Brain Microvascular Endothelial Cells
Pteridines, 1999 We examined the effects of insulin on tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells (MBMECs). Treatment of MBMECs with insulin increased the intracellular BH4 content in a time- and concentration-dependent manner. The
Ishi Masakazu +4 more
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Van Tıp DergisiINTRODUCTION: Aim: This study investigates the relationship between serum tetrahydrobiopterin (BH4) and folic acid levels in pregnant women during the second and third trimesters and the development of preeclampsia.
Mücahit Ahmet Aranlı +4 more
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Treatments for Biomedical Abnormalities Associated with Autism Spectrum Disorder
Frontiers in Pediatrics, 2014 Recent studies point to the effectiveness of novel treatments that address physiological abnormalities associated with autism spectrum disorder (ASD). This is significant because safe and effective treatments for ASD remain limited.
Richard Eugene Frye, Daniel eRossignol
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Pteridines, 2002 Tetrahydrobiopterin (BH4) is one of the cofactors for nitric oxide synthase (NOS), and also has a protective effect against reactive oxygen species (ROS)- and/or nitric oxide (NO)-induced cytotoxicities. Lipopolysaccharide (LPS) induces NO production and
Shiota Kazuhiro +6 more
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Pteridines, 2001 A pteridine glycoside in Synechococcus sp. PCC 7942, the structure of which had been tentatively identified as biopterin-glucoside, was isolated and characterized for its exact chemical structure by 2D-NMR spectroscopy. The determined structure is 1-0-(L-
Choi Yong Kee +3 more
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