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Tetrahydrobiopterin and Cardiovascular Disease [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2006
Tetrahydrobiopterin (BH 4 ) is an essential cofactor for the aromatic amino acid hydroxylases, which are essential in the formation of neurotransmitters, and for nitric oxide synthase. It is presently used clinically to treat some forms of phenylketonuria (PKU) that can be ameliorated by BH 4
David Kass, An L Moens
exaly   +4 more sources

Tetrahydrobiopterin in nitric oxide synthase [PDF]

IUBMB Life, 2013
AbstractSummary: Nitric oxide synthase (NOS) is a critical enzyme for the production of the messenger molecule nitric oxide (NO) from L‐arginine. NOS enzymes require tetrahydrobiopterin as a cofactor for NO synthesis. Besides being one of the few enzymes to use this cofactor, the role of tetrahydrobiopterin in NOS catalytic mechanism is different from ...
Dennis Stuehr, Jesus Tejero
exaly   +3 more sources

Uncoupled nitric oxide synthase activity promotes colorectal cancer progression

Frontiers in Oncology, 2023
Increased levels of reactive oxygen/nitrogen species are one hallmark of chronic inflammation contributing to the activation of pro-inflammatory/proliferative pathways. In the cancers analyzed, the tetrahydrobiopterin:dihydrobiopterin ratio is lower than
Asim Alam, Steven C. Smith, Sundaresan Gobalakrishnan, Mina McGinn, Vasily A. Yakovlev, Christopher S. Rabender   +5 more
doaj   +1 more source

Nitric Oxide in the Spinal Cord Is Involved in the Hyperalgesia Induced by Tetrahydrobiopterin in Chronic Restraint Stress Rats

Frontiers in Neuroscience, 2021
It has been well recognized that exposure to chronic stress could increase pain responding and exacerbate pain symptoms, resulting in stress-induced hyperalgesia. However, the mechanisms underlying stress-induced hyperalgesia are not yet fully elucidated.
Ying Huang, Ying Huang, Bo Jiao, Bo Zhu, Bingrui Xiong, Pei Lu, Ling Ai, Ning Yang, Yilin Zhao, Hui Xu   +9 more
doaj   +1 more source

Neuronal vulnerability to fetal hypoxia-reoxygenation injury and motor deficit development relies on regional brain tetrahydrobiopterin levels

Redox Biology, 2020
Hypertonia is pathognomonic of cerebral palsy (CP), often caused by brain injury before birth. To understand the early driving events of hypertonia, we utilized magnetic resonance imaging (MRI) assessment of early critical brain injury in rabbit fetuses (
Jeannette Vasquez-Vivar, Zhongjie Shi, Jeong-Won Jeong, Kehuan Luo, Amit Sharma, Karthikeyan Thirugnanam, Sidhartha Tan   +6 more
doaj   +1 more source

Biosynthesis of tetrahydrobiopterin in man [PDF]

Journal of Inherited Metabolic Disease, 1985
AbstractThe biosynthesis of tetrahydrobiopterin (BH4) from dihydroneopterin triphosphate (NH2P3) was studied in human liver extract. The phosphate‐eliminating enzyme (PEE) was purified ~750‐fold. The conversion of NH2P3 to BH4 was catalyzed by this enzyme in the presence of partially purified sepiapterin reductase, Mg2+ and NADPH.
Curtius, Hans-Christoph, Heintel, Dorothee, Kuster, Thomas, Leimbacher, Walter, Niederwieser, Alois, Ghisla, Sandro   +5 more
openaire   +3 more sources

Tetrahydrobiopterin [PDF]

Hypertension, 2011
See related article, pp 287–294 Tetrahydrobiopterin (BH4), an essential cofactor for diverse cellular processes, is present in almost every cell or tissue of higher organisms. BH4 has well-defined functions in terms of enzymatic activities (BH4 is a crucial cofactor for the aromatic amino acid hydroxylases and all isoforms of nitric oxide synthase ...
Cynthia J. Meininger, Guoyao Wu
openaire   +1 more source

Tetrahydrobiopterin deficiency in schizophrenia as a new target for personalized medicine

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2020
Summary. Tetrahydrobiopterin (BH4) is an important cofactor, that involved in the synthesis of dopamine, norepinephrine, and serotonin, as well as affecting the production of nitric oxide (NO) and regulating the activity of the glutamatergic system.
I. V. Semennov, Y. S. Zagryazhskaya, A. S. Piatoikina, T. V. Zhilyaeva, E. A. Manakova A., A. S. Blagonravova, E. V. Verbitskaya, G. E. Mazo   +7 more
doaj   +1 more source

Advances in the Microbial Synthesis of 5-Hydroxytryptophan

Frontiers in Bioengineering and Biotechnology, 2021
5-Hydroxytryptophan (5-HTP) plays an important role in the regulation of emotion, behavior, sleep, pain, body temperature, and other physiological functions. It is used in the treatment of depression, insomnia, migraine, and other diseases. Due to a lack
Xin-Xin Liu, Bin Zhang, Lian-Zhong Ai
doaj   +1 more source

Tetrahydrobiopterin and Cytokines

Experimental Biology and Medicine, 1993
Biosynthesis of tetrahydrobiopterin starts from guanosine triphosphate by the action of guanosine triphosphate cyclohydrolase I, which yields the first intermediate, 7,8-dihydroneopterin triphosphate. This compound is then converted by subsequent enzymes, 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase, to tetrahydrobiopterin, the ...
E R, Werner, G, Werner-Felmayer, H, Wachter   +2 more
openaire   +2 more sources