Results 21 to 30 of about 20,824 (230)

Tetrahydrobiopterin attenuates ischemia-reperfusion injury following organ transplantation by targeting the nitric oxide synthase: investigations in an animal model

Pteridines, 2013
Ischemia-reperfusion injury is a primarily non-allospecific event leading to the depletion of the essential nitric oxide synthase cofactor and potent antioxidant tetrahydrobiopterin.
Cardini Benno, Oberhuber Rupert, Hein Sven R., Watschinger Katrin, Hermann Martin, Obrist Peter, Werner-Felmayer Gabriele, Brandacher Gerald, Pratschke Johann, Werner Ernst R., Maglione Manuel   +10 more
doaj   +1 more source

Tetrahydrobiopterin Uptake in Supplemental Administration: Elevation of Tissue Tetrahydrobiopterin in Mice Following Uptake of the Exogenously Oxidized Product 7,8-Dihydrobiopterin and Subsequent Reduction by an Anti-folate-Sensitive Process

Journal of Pharmacological Sciences, 2004
In order to increase the tissue level of tetrahydrobiopterin (BH4), supplementation with 6R-tetrahydrobiopterin (6RBH4) has been widely employed. In this work, the effectiveness of 6RBH4 was compared with 7,8-dihydrobiopterin (7,8BH2) and sepiapterin by ...
Keiko Sawabe, Kazunori Osuke Wakasugi, Hiroyuki Hasegawa   +2 more
doaj   +1 more source

Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability

Biomolecules, 2021
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The initial stage of CVDs is characterized by endothelial dysfunction, defined as the limited bioavailability of nitric oxide (NO).
Anna Janaszak-Jasiecka, Anna Siekierzycka, Agata Płoska, Iwona T. Dobrucki, Leszek Kalinowski   +4 more
doaj   +1 more source

Pharmacology and clinical drug candidates in redox medicine [PDF]

, 2015
SIGNIFICANCE Oxidative stress is suggested to be a disease mechanism common to a wide range of disorders affecting human health. However, so far, the pharmacotherapeutic exploitation of this, for example, based on chemical scavenging of pro-oxidant ...
Casas, Ana I, Cuadrado, Antonio, Dao, V Thao-Vi, Di Lisa, Fabio, Ghezzi, Pietro, Jaquet, Vincent, Kaludercic, Nina, Maghzal, Ghassan J, Robledinos-Anton, Natalia, Schmidt, Harald H H W, Seredenina, Tamara, Stocker, Roland   +11 more
core   +3 more sources

Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation.

PLoS ONE, 2014
ObjectiveAim of this study was to identify the nitric oxide synthase (NOS) isoform involved in early microcirculatory derangements following solid organ transplantation.BackgroundTetrahydrobiopterin donor treatment has been shown to specifically ...
Benno Cardini, Katrin Watschinger, Martin Hermann, Peter Obrist, Rupert Oberhuber, Gerald Brandacher, Surawee Chuaiphichai, Keith M Channon, Johann Pratschke, Manuel Maglione, Ernst R Werner   +10 more
doaj   +1 more source

Extra virgin olive oil and cardiovascular diseases: benefits for human health [PDF]

, 2017
The cardioprotective properties of Mediterranean Diet were demonstrated for the first time from the Seven Country Study. In the last few decades, numerous epidemiological studies, as well as intervention trial, confirmed this observation, pointing out ...
Cammisotto, Vittoria, Carnevale, Roberto, Castellani, Valentina, D'Amico, Alessandra, Fianchini, Luca, Nocella, Cristina, Novo, Marta, Stefanini, Lucia, Violi, Francesco   +8 more
core   +1 more source

Tetrahydrobiopterin and Cytokines

Experimental Biology and Medicine, 1993
Biosynthesis of tetrahydrobiopterin starts from guanosine triphosphate by the action of guanosine triphosphate cyclohydrolase I, which yields the first intermediate, 7,8-dihydroneopterin triphosphate. This compound is then converted by subsequent enzymes, 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase, to tetrahydrobiopterin, the ...
E R, Werner, G, Werner-Felmayer, H, Wachter   +2 more
openaire   +2 more sources

Compensatory Feto-Placental Upregulation of the Nitric Oxide System during Fetal Growth Restriction [PDF]

, 2012
Background: Fetal Growth Restriction is often associated with a feto-placental vascular dysfunction conceivably involving endothelial cells. Our study aimed to verify this pathogenic role for feto-placental endothelial cells and, coincidentally ...
Begliuomini, Silvia, Boldrini, Antonio, Casarosa, Elena, Coceani, Flavio, Fink, Bruno, Genazzani, Andrea R., Ghirri, Paolo, Pisaneschi, Silvia, Ripoli, Andrea, Sanchez, Angel Matias, Simoncini, Tommaso, Strigini, Francesca A. L.   +11 more
core   +3 more sources

Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]

, 2009
Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Alasdair R. Boyd, Aljada, Andreozzi, Bauer, Boyle, Christine F. Kohlhaas, Church, Federici, Gallis, Harris, Ian P. Salt, John M. C. Connell, Kenneth Walsh, Kim, Kou, Krishna C. Yalla, Li, Li, Luo, Michell, Morrow, Mount, Potenza, Potenza, Reihill, Repetto, Salt, Steinberg, Stuart A. Ritchie, Takahashi, Tran, Ueda, Zeng   +32 more
core   +5 more sources

Insights from a Murine Aortic Transplantation Model [PDF]

, 2016
Transplant vasculopathy (TV) represents a major obstacle to long-term graft survival and correlates with severity of ischemia reperfusion injury (IRI). Donor administration of the nitric oxide synthases (NOS) co-factor tetrahydrobiopterin has been shown ...
Bernhard, David, Brandacher, Gerald, Cardini, Benno, Golderer, Georg, Maglione, Manuel, Messner, Barbara, Oberhuber, Rupert, Pratschke, Johann, Riede, Gregor, Steger, Christina, Watschinger, Katrin, Werner, Ernst R.   +11 more
core   +1 more source