Results 21 to 30 of about 14,507 (223)

Tetrahydrobiopterin deficiency in schizophrenia as a new target for personalized medicine

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2020
Summary. Tetrahydrobiopterin (BH4) is an important cofactor, that involved in the synthesis of dopamine, norepinephrine, and serotonin, as well as affecting the production of nitric oxide (NO) and regulating the activity of the glutamatergic system.
I. V. Semennov, Y. S. Zagryazhskaya, A. S. Piatoikina, T. V. Zhilyaeva, E. A. Manakova A., A. S. Blagonravova, E. V. Verbitskaya, G. E. Mazo   +7 more
doaj   +1 more source

Advances in the Microbial Synthesis of 5-Hydroxytryptophan

Frontiers in Bioengineering and Biotechnology, 2021
5-Hydroxytryptophan (5-HTP) plays an important role in the regulation of emotion, behavior, sleep, pain, body temperature, and other physiological functions. It is used in the treatment of depression, insomnia, migraine, and other diseases. Due to a lack
Xin-Xin Liu, Bin Zhang, Lian-Zhong Ai
doaj   +1 more source

Tetrahydrobiopterin and Cytokines

Experimental Biology and Medicine, 1993
Biosynthesis of tetrahydrobiopterin starts from guanosine triphosphate by the action of guanosine triphosphate cyclohydrolase I, which yields the first intermediate, 7,8-dihydroneopterin triphosphate. This compound is then converted by subsequent enzymes, 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase, to tetrahydrobiopterin, the ...
E R, Werner, G, Werner-Felmayer, H, Wachter   +2 more
openaire   +2 more sources

Tetrahydrobiopterin in biomedical research [PDF]

Journal of Inherited Metabolic Disease, 2009
Tetrahydrobiopterin (BH4) is an endogenously synthesized cofactor, required for various enzyme activities and for some less well-defined functions. It is also required at the cellular level. The known enzymes that depend on BH4 are phenylalanine hydroxylase (PAH), tyrosine hydroxylase, tryptophan hydroxylases 1 and 2, all three types of nitric oxide ...
Blau, Nenad, Thöny, Beat
openaire   +3 more sources

TETRAHYDROBIOPTERIN BIOSYNTHESIS [PDF]

, 1982
published
Curtius, Hans-Christoph, Häusermann, Max, Niederwieser, Alois, Ghisla, Sandro   +3 more
openaire   +2 more sources

A Comparison of Sepiapterin and Tetrahydrobiopterin Uptake by BRL2H3 Cells

Pteridines, 1996
Cellular uptake of sepiapterin and tetrahydrobiopterin was compared quantitatively with RBL2H3 cells in culture. RBL2H3 is a mast cell line and has the ability to synthesize serotonin.
Yamamoto Kazumasa, Nagano Mutsumi, Nakanishi Nobuo, Hasegawa Hiroyuki   +3 more
doaj   +1 more source

Response of Phenylketonuria to Tetrahydrobiopterin [PDF]

The Journal of Nutrition, 2007
A favorable response, indicated by decline of blood phenylalanine (Phe) in patients with phenylketonuria (PKU), to orally administered 6-R-L-erythro-5, 6, 7, 8-tetrahydrobiopterin (BH4) has been reported in many countries following the first publication in 1999. In this review, we describe the experience in the United States with PKU patients and their
Kimberlee, Michals-Matalon, Gita, Bhatia, Flemming, Guttler, Stephen K, Tyring, Reuben, Matalon   +4 more
openaire   +2 more sources

Tetrahydrobiopterin attenuates ischemia-reperfusion injury following organ transplantation by targeting the nitric oxide synthase: investigations in an animal model

Pteridines, 2013
Ischemia-reperfusion injury is a primarily non-allospecific event leading to the depletion of the essential nitric oxide synthase cofactor and potent antioxidant tetrahydrobiopterin.
Cardini Benno, Oberhuber Rupert, Hein Sven R., Watschinger Katrin, Hermann Martin, Obrist Peter, Werner-Felmayer Gabriele, Brandacher Gerald, Pratschke Johann, Werner Ernst R., Maglione Manuel   +10 more
doaj   +1 more source

Tetrahydrobiopterin Uptake in Supplemental Administration: Elevation of Tissue Tetrahydrobiopterin in Mice Following Uptake of the Exogenously Oxidized Product 7,8-Dihydrobiopterin and Subsequent Reduction by an Anti-folate-Sensitive Process

Journal of Pharmacological Sciences, 2004
In order to increase the tissue level of tetrahydrobiopterin (BH4), supplementation with 6R-tetrahydrobiopterin (6RBH4) has been widely employed. In this work, the effectiveness of 6RBH4 was compared with 7,8-dihydrobiopterin (7,8BH2) and sepiapterin by ...
Keiko Sawabe, Kazunori Osuke Wakasugi, Hiroyuki Hasegawa   +2 more
doaj   +1 more source

Markers of Systemic Metabolic Dysfunction in Vitiligo and Their Potential Role in Disease Pathogenesis: A Narrative Review. [PDF]

Health Sci Rep
ABSTRACT Background Vitiligo is a chronic autoimmune disease characterized by the progressive destruction of melanocytes, resulting in depigmented skin macules. While traditionally viewed as a cutaneous disorder driven by a specific CD8+ T cell‐mediated interferon‐γ (IFN‐γ) signature, emerging research suggests that vitiligo may be a systemic condition
Papaccio F, Scano S, Bellei B.
europepmc   +2 more sources