Results 31 to 40 of about 10,182 (138)
Tetrahydrobiopterin in phenylketonuria: Who can benefit? [PDF]
, 2020 Phenylketonuria, abbreviated PKU, is a rare inherited metabolic disease. In this disease, a building block of protein (an amino acid) called phenylalanine cannot be converted to tyrosine. This results in high phenylalanine concentrations in blood and brain. If left untreated, this especially results in severe developmental delay as well as epilepsy and
openaire +2 more sources
The Intricate Mechanism of Nitric Oxide Synthase
Journal of Computational Chemistry, Volume 47, Issue 17, 30 June 2026.The mechanism for NO formation by Nitric Oxide Synthase (NOS) has been studied using accurate DFT methods. A long‐range electron transfer from the cofactor H4B leads to formation of H2O2. ABSTRACT The biological formation of NO is performed by nitric oxide synthase.
Per E. M. Siegbahn
wiley +1 more source
Impact of Gut Microbiota Metabolites on Serotonin Levels in Irritable Bowel Syndrome
Gut Medicine, Volume 2, Issue 2, Page 98-111, June 2026.ABSTRACT Gut microbiota and their metabolites have been proposed as possible etiological factors in irritable bowel syndrome (IBS), and studies suggest that IBS is associated with impaired serotonin synthesis and release. Microbial metabolites are produced through biological pathways and enzymatic processes via gut microbiota.
Ning Gao +7 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.Endothelial ILK loss drives RIPK1‐enriched EVs that propagate systemic endothelial activation and cardiovascular remodelling. EV cargo remodelling induces early endothelial injury, microvascular dysfunction and chronic cardiac alterations through a RIPK1 dependent pathway.
Alberto Cook‐Calvete +9 more
wiley +1 more source
Tetrahydrobiopterin, superoxide, and vascular dysfunction [PDF]
Free Radical Biology and Medicine, 2009 (6R)-5,6,7,8-Tetrahydrobiopterin (BH(4)) is an endogenously produced pterin that is found widely distributed in mammalian tissues. BH(4) works as a cofactor of aromatic amino acid hydroxylases and nitric oxide synthases. In the vasculature a deficit of BH(4) is implicated in the mechanisms of several diseases including atherosclerosis, hypertension ...
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Maintenance of cellular tetrahydrobiopterin homeostasis
BMB Reports, 2010 Tetrahydrobiopterin (BH4) is a multifunctional cofactor of aromatic amino acid hydroxylases and nitric oxide synthase (NOS) as well as an intracellular antioxidant in animals. Through regulation of NOS activity BH4 plays a pivotal role not only in a variety of normal cellular functions but also in the pathogenesis of cardiovascular and ...
Hye-Lim, Kim, Young Shik, Park
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Tetrahydrobiopterin and inherited hyperphenylalaninemias.
The Turkish journal of pediatrics, 1996 Tetrahydrobiopterin deficiency, a variant of hyperphenylalaninemia, may be caused by deficiency of one of the following enzymes: guanosine triphosphate cyclohydrolase 1,6-pyruvoyltetrahydropterin synthase, dihydropteridin reductase and pterin-4a-carbinolamine dehydratase.
Blau N, Thony B, Spada M, Ponzone A
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Tetrahydrobiopterin control in phenylketonuria [PDF]
Genetics in Medicine, 2003 openaire +2 more sources
Structural and mechanistic insights into the divergence of pterin deaminase and sepiapterin deaminase. [PDF]
Appl Microbiol BiotechnolShanmuganathan N +7 more
europepmc +1 more source