Results 31 to 40 of about 14,507 (223)

Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability

Biomolecules, 2021
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. The initial stage of CVDs is characterized by endothelial dysfunction, defined as the limited bioavailability of nitric oxide (NO).
Anna Janaszak-Jasiecka, Anna Siekierzycka, Agata Płoska, Iwona T. Dobrucki, Leszek Kalinowski   +4 more
doaj   +1 more source

Unveiling the Complete Biosynthetic Pathway of Azacitidine: A Rare 1,3,5‐Triazine Nucleoside Derived From GTP

Angewandte Chemie, EarlyView.
The azacitidine biosynthetic gene cluster (aza BGC) was identified by the resistance‐gene‐guided comparative genomics method in Streptomyces mobaraensis IPIO2. The complete biosynthetic pathway of azacitidine, which follows a “base‐first‐then‐glycosylation” logic, was elucidated through in vivo and in vitro experiments.
Dan Wang, Qingxu Meng, Lingqi Hua, Mengjun Sun, Qianjin Kang, Min‐Juan Xu, Linquan Bai   +6 more
wiley   +2 more sources

Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation.

PLoS ONE, 2014
ObjectiveAim of this study was to identify the nitric oxide synthase (NOS) isoform involved in early microcirculatory derangements following solid organ transplantation.BackgroundTetrahydrobiopterin donor treatment has been shown to specifically ...
Benno Cardini, Katrin Watschinger, Martin Hermann, Peter Obrist, Rupert Oberhuber, Gerald Brandacher, Surawee Chuaiphichai, Keith M Channon, Johann Pratschke, Manuel Maglione, Ernst R Werner   +10 more
doaj   +1 more source

Tetrahydrobiopterin restores endothelial function in hypercholesterolemia [PDF]

, 1997
In hypercholesterolemia, impaired nitric oxide activity has been associated with increased nitric oxide degradation by oxygen radicals. Deficiency of tetrahydrobiopterin, an essential cofactor of nitric oxide synthase, causes both impaired nitric oxide ...
Stroes, E.S.G., E. Stroes, Kastelein, J.J.P., Erkelens, W., J. Kastelein, H. Koomans, E Stroes, T Rabelink, W Erkelens, Koomans, H., F Cosentino, R. Wever, W. Erkelens, Cosentino, F., Wever, R., T Lüscher, COSENTINO, Francesco, R Wever, T. Rabelink, T. Luscher, H Koomans, J Kastelein, Luscher, T.   +22 more
core   +1 more source

Tetrahydrobiopterin Biosynthesis in Man [PDF]

, 1986
published
Curtius, Hans-Christoph, Takikawa, Shin-Ichiro, Niederwieser, Alois, Ghisla, Sandro   +3 more
openaire   +2 more sources

A novel function of tetrahydrobiopterin.

Folia Pharmacologica Japonica, 1992
6R-L-erythro-5, 6, 7, 8-Tetrahydrobiopterin (6R-BH4) is known as a cofactor for the hydroxylases of phenylalanine, tyrosine and tryptophan and also as a cofactor for nitric oxide synthase. Recently, a novel function of 6R-BH4 has been found: that is, 6R-BH4 acts on specific membrane receptors to directly stimulate the release of monamine ...
MIWA, Soichi, WATANABE, Yasuyoshi, KOSHIMURA, Kunio, MASAKI, Tomoh   +3 more
openaire   +3 more sources

Effect of Interferon-γ and LPS on Tetrahydrobiopterin in Rat PC 12 and Human KNA Cells

Pteridines, 2001
The first human phaeochromocytorna cell line KNA was tested with regard to stimulation of dopamine biosynthesis by nicotinamide adenine dinucleotide (NADH).
Vrecko Karoline, Pfragner Roswitha, Siegl Veronika, Schauenstein Konrad, Reibnegger Gilbert   +4 more
doaj   +1 more source

Tetrahydrobiopterin Supplementation Improves Endothelial Function But Does Not Alter Aortic Stiffness in Patients With Rheumatoid Arthritis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundRheumatoid arthritis is a systemic inflammatory condition associated with increased cardiovascular risk that may be due to underlying endothelial dysfunction and subsequent aortic stiffening.
Kaisa M. Mäki‐Petäjä, Lisa Day, Joseph Cheriyan, Frances C. Hall, Andrew J. K. Östör, Nicholas Shenker, Ian B. Wilkinson   +6 more
doaj   +1 more source

Perspectives on tetrahydrobiopterin research.

Folia Pharmacologica Japonica, 2001
Tetrahydrobiopterin ((6R)-L-erythro-tetrahydrobiopterin, BH4) is de novo synthesized from GTP. Enzymes involved in its synthesis are the rate limiting enzyme GTP cyclohydrolase I, 6-pyruvoyl tetrahydropterin synthase (PTPS) and sepiapterin reductase. Abnormalities in the metabolism of BH4 have been demonstrated in some diseases affecting the central ...
SUMI-ICHINOSE, Chiho, OHTSUKI, Masatsugu, SHIRAISHI, Hiroaki, NOMURA, Takahide   +3 more
openaire   +3 more sources

AGMO Inhibitor Reduces 3T3-L1 Adipogenesis

Cells, 2021
Alkylglycerol monooxygenase (AGMO) is a tetrahydrobiopterin (BH4)-dependent enzyme with major expression in the liver and white adipose tissue that cleaves alkyl ether glycerolipids.
Caroline Fischer, Annett Wilken-Schmitz, Victor Hernandez-Olmos, Ewgenij Proschak, Holger Stark, Ingrid Fleming, Andreas Weigert, Manuela Thurn, Martine Hofmann, Ernst R. Werner, Gerd Geisslinger, Ellen Niederberger, Katrin Watschinger, Irmgard Tegeder   +13 more
doaj   +1 more source