Results 41 to 50 of about 14,507 (223)

Biopterin metabolism and nitric oxide recoupling in cancer

Frontiers in Oncology
Tetrahydrobiopterin is a cofactor necessary for the activity of several enzymes, the most studied of which is nitric oxide synthase. The role of this cofactor-enzyme relationship in vascular biology is well established.
Gene Chatman Clark, Gene Chatman Clark, Alan Lai, Aashri Agarwal, Zheng Liu, Zheng Liu, Xiang-Yang Wang, Xiang-Yang Wang, Xiang-Yang Wang   +8 more
doaj   +1 more source

Tetrahydrobiopterin Regulates L-tyrosine-induced Elevation of Cytosolic Calcium Concentration in Insulin-secreting Cells

Pteridines, 2006
We examined the role of endogenous tetrahydrobiopterin (BH4) on L-tyrosine-induced increase in cytosolic Ca: concentration ([Ca2+],) in the ß-cell line, HIT-T15.
Ishii Masakazu, Shimizu Shunichi, Watabe Tatsuya, Kiuchi Yuji   +3 more
doaj   +1 more source

First insights into structure-function relationships of alkylglycerol monooxygenase

Pteridines, 2013
Alkylglycerol monooxygenase is a tetrahydrobiopterin-dependent enzyme that cleaves the O-alkyl-bond of alkylglycerols. It is an exceptionally unstable, hydrophobic membrane protein which has never been purified in active form.
Watschinger Katrin, Fuchs Julian E., Yarov-Yarovoy Vladimir, Keller Markus A., Golderer Georg, Hermetter Albin, Werner-Felmayer Gabriele, Hulo Nicolas, Werner Ernst R.   +8 more
doaj   +1 more source

Characterization of the Protective Effect of Tetrahydrobiopterin Against S-Nitroso-N -Acetyl-D ,L-Penicillamine Induced Endothelial Cell Injury

Pteridines, 1999
The purpose of this study was to characterize the protective effect of tetrahydrobiopterin (BH4), one of the cofactors of nitric oxide (NO) synthase, against NO-induced endothelial cell injury. The addition of S-nitroso-N-acetyl-D,L-penicillamine (SNAP),
Ishii Masakazu, Shimizu Shunichi, Momose Kazutaka, Kiuchi Yuji, Yamamoto Toshinori   +4 more
doaj   +1 more source

Vascular endothelial dysfunction: does tetrahydrobiopterin play a role?

, 2001
Tetrahydrobiopterin is one of the most potent naturally occurring reducing agents and an essential cofactor required for enzymatic activity of nitric oxide synthase (NOS).
Zvonimir S. Katusic
core   +1 more source

Fatty aldehyde dehydrogenase, the enzyme downstream of tetrahydrobiopterin-dependent alkylglycerol monooxygenase

Pteridines, 2013
The tetrahydrobiopterin-dependent degradation of ether lipids by alkylglycerol monooxygenase (AGMO) produces fatty aldehydes, which are toxic to cells.
Keller Markus A., Watschinger Katrin, Golderer Georg, Werner-Felmayer Gabriele, Werner Ernst R.   +4 more
doaj   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Tetrahydrobiopterin Role in human umbilical vein endothelial dysfunction in maternal supraphysiological hypercholesterolemia [PDF]

, 2016
Maternal physiological hypercholesterolemia (MPH) allows a proper foetal development; however, maternal supraphysiological hypercholesterolemia (MSPH) associates with foetal endothelial dysfunction and early development of atherosclerosis.
Leiva Mendoza, Andrea Alejandra, Leiva, Andrea, Barros, Eric, Pardo, Fabian, Sobrevia, Luis, Gutierrez, Jaime, Salsoso Rodríguez, M. Rocío, Salsoso, Rocio, Fuenzalida Saavedra, Bárbara, Sobrevía Luarte, Luis Alberto, Fuenzalida, Barbara, Toledo, Fernando   +11 more
core   +1 more source

Investigation of a potential role for aldose reductase AlrA in tetrahydropteridine synthesis in Dictyostelium discoideum Ax2

Pteridines, 2017
Dictyostelium discoideum Ax2 is well-known for the synthesis of d-threo-tetrahydrobiopterin (DH4) with a smaller amount of l-erythro-tetrahydrobiopterin (BH4).
Kim Hye-Lim, Ryu Hyun-Chul, Park Young Shik   +2 more
doaj   +1 more source

Tetrahydrobiopterin: biochemistry and pathophysiology

Biochemical Journal, 2011
BH4 (6R-L-erythro-5,6,7,8-tetrahydrobiopterin) is an essential cofactor of a set of enzymes that are of central metabolic importance, including four aromatic amino acid hydroxylases, alkylglycerol mono-oxygenase and three NOS (NO synthase) isoenzymes. Consequently, BH4 is present in probably every cell or tissue of higher organisms and plays a key role
Werner, E R, Blau, N, Thöny, B
openaire   +3 more sources