Results 1 to 10 of about 293 (70)

Alkylglycerol monooxygenase represses prostanoid biosynthesis in a sex-dependent manner [PDF]

Cell and Bioscience
Background Ether lipids are important constituents of biological membranes and harbor fatty alcohols attached via ether linkages to the sn-1 position of the glycerol backbone. Depending on the nature of the ether bond, they are subdivided into 1-O-alkyl (
Andreas Koeberle, Katrin Watschinger, Natascha Brigo   +2 more
exaly   +3 more sources

Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown [PDF]

Journal of Lipid Research, 2022
Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether lipids.
Sabrina Sailer, Katharina Lackner, Mia L. Pras-Raves, Eric J.M. Wever, Jan B. van Klinken, Adriaan D. Dane, Stephan Geley, Jakob Koch, Georg Golderer, Gabriele Werner-Felmayer, Markus A. Keller, Werner Zwerschke, Frédéric M. Vaz, Ernst R. Werner, Katrin Watschinger   +14 more
doaj   +2 more sources

AGMO Inhibitor Reduces 3T3-L1 Adipogenesis [PDF]

Cells, 2021
Alkylglycerol monooxygenase (AGMO) is a tetrahydrobiopterin (BH4)-dependent enzyme with major expression in the liver and white adipose tissue that cleaves alkyl ether glycerolipids.
Caroline Fischer, Annett Wilken-Schmitz, Victor Hernandez-Olmos, Ewgenij Proschak, Holger Stark, Ingrid Fleming, Andreas Weigert, Manuela Thurn, Martine Hofmann, Ernst R. Werner, Gerd Geisslinger, Ellen Niederberger, Katrin Watschinger, Irmgard Tegeder   +13 more
doaj   +2 more sources

The Emerging Physiological Role of AGMO 10 Years after Its Gene Identification [PDF]

Life, 2021
The gene encoding alkylglycerol monooxygenase (AGMO) was assigned 10 years ago. So far, AGMO is the only known enzyme capable of catalysing the breakdown of alkylglycerols and lyso-alkylglycerophospholipids. With the knowledge of the genetic information,
Sabrina Sailer, Markus A. Keller, Ernst R. Werner, Katrin Watschinger   +3 more
doaj   +2 more sources

Make or break - PEDS1 and AGMO orchestrate ether lipid homeostasis in human adipocytes and are associated with blood lipid profiles [PDF]

Journal of Translational Medicine
Background Obesity and its associated sequelae have become a major global health concern. While ester-linked lipids are well-established regulators of adipocyte function and energy storage. Emerging evidence from cohort studies suggests that ether-linked
Sabrina Sailer, Tina Deutinger, Susanne Lobenwein, Katharina Lackner, Stephan Geley, Georg Golderer, Ernst R. Werner, Markus A. Keller, Christian Ploner, Katrin Watschinger   +9 more
doaj   +2 more sources

First insights into structure-function relationships of alkylglycerol monooxygenase

Pteridines, 2013
Alkylglycerol monooxygenase is a tetrahydrobiopterin-dependent enzyme that cleaves the O-alkyl-bond of alkylglycerols. It is an exceptionally unstable, hydrophobic membrane protein which has never been purified in active form.
Katrin Watschinger, Vladimir Yarov-Yarovoy, Gabriele Werner-Felmayer   +2 more
exaly   +2 more sources

Fatty aldehyde dehydrogenase, the enzyme downstream of tetrahydrobiopterin-dependent alkylglycerol monooxygenase

Pteridines, 2013
The tetrahydrobiopterin-dependent degradation of ether lipids by alkylglycerol monooxygenase (AGMO) produces fatty aldehydes, which are toxic to cells.
Katrin Watschinger, Gabriele Werner-Felmayer, Markus A Keller   +2 more
exaly   +2 more sources

Expression of full-length human alkylglycerol monooxygenase and fragments in Escherichia coli

Pteridines, 2013
Alkylglycerol monooxygenase (AGMO; EC 1.14.16.5) is the only enzyme known to cleave the O-alkyl ether bond of alkylglycerols in humans. It is an integral membrane protein with nine predicted transmembrane domains.
Katrin Watschinger, Gabriele Werner-Felmayer, Matthias P. Mayer   +2 more
exaly   +2 more sources

Affinity purification of alkylglycerol monooxygenase from rat liver microsomes by chimyl alcohol-Sepharose 4B column chromatography.

Journal of Lipid Research, 1985
Alkylglycerol monooxygenase of rat liver microsomes was purified approximately to 97-fold with a 30% yield by procedures including affinity chromatography on chimyl alcohol-Sepharose 4B.
T Ishibashi, Y Imai
exaly   +3 more sources

Alkylglycerol monooxygenase [PDF]

IUBMB Life, 2013
Katrin Watschinger, Ernst R Werner
exaly   +2 more sources