Tetrahydrobiopterin and alkylglycerol monooxygenase substantially alter the murine macrophage lipidome [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2015 Tetrahydrobiopterin is a cofactor synthesized from GTP with well-known roles in enzymatic nitric oxide synthesis and aromatic amino acid hydroxylation. It is used to treat mild forms of phenylketonuria. Less is known about the role of tetrahydrobiopterin
Giuseppe Astarita +2 more
exaly +7 more sources
Oxidative cyclization of prodigiosin by an alkylglycerol monooxygenase-like enzyme [PDF]
Nature Chemical Biology, 2017 Prodiginines, which are tripyrrole alkaloids displaying a wide array of bioactivities, occur as linear and cyclic congeners. Identification of an unclustered biosynthetic gene led to the discovery of the enzyme responsible for catalyzing the ...
Edward E K Baidoo +2 more
exaly +10 more sources
Identification of the gene encoding alkylglycerol monooxygenase defines a third class of tetrahydrobiopterin-dependent enzymes [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2010 Alkylglycerol monooxygenase (glyceryl-ether monooxygenase, EC 1.14.16.5) is the only enzyme known to cleave the O-alkyl bond of ether lipids which are essential components of brain membranes, protect the eye from cataract, interfere or ...
Katrin Watschinger +2 more
exaly +7 more sources
Alkylglycerol monooxygenase, a heterotaxy candidate gene, regulates left-right patterning via Wnt signaling [PDF]
Developmental Biology, 2019 Congenital heart disease (CHD) is a major cause of morbidity in the pediatric population yet its genetic and molecular causes remain poorly defined.
Andrew Robson +2 more
exaly +6 more sources
Alkylglycerol monooxygenase and its physiological role in adipocytes
, 2016 Kurzfassung Hintergrund: Alkylglycerol Monooxygenase (AGMO, E.C 1.14.16.5) ist eines von 8 Tetrahydrobiopterin abhängigen Enzymen und spaltet als einziges die Etherbindung in Alkylglycerole und lyso-Alkylglycerophospholipide.
Sailer, Sabrina
core +5 more sources
Three classes of tetrahydrobiopterin-dependent enzymes
Pteridines, 2013 Current knowledge distinguishes three classes of tetrahydrobiopterin-dependent enzymes as based on protein sequence similarity. These three protein sequence clusters hydroxylate three types of substrate atoms and use three different forms of iron for ...
Werner Ernst R.
doaj +2 more sources
Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglycerol mono-oxygenase [PDF]
Biochemical Journal, 2012 Alkylglycerol mono-oxygenase (EC 1.14.16.5) forms a third, distinct, class among tetrahydrobiopterin-dependent enzymes in addition to aromatic amino acid hydroxylases and nitric oxide synthases.
Watschinger, Katrin +11 more
core +8 more sources
Investigation of the Protective Effect of Probiotic Lactobacillus plantarum Ep-M17 on the Hepatopancreas of Penaeus vannamei. [PDF]
Aquac NutrInfection with the pathogenic bacterium Vibrio parahaemolyticus typically causes severe hepatopancreatic damage in Penaeus vannamei, often resulting in acute shrimp mortality. Therefore, protecting the shrimp’s hepatopancreas is crucial for enhancing their disease resistance.
Hu X, Xu W, Li H, Lu B, Du Y, Chen J.
europepmc +2 more sources
Experimental Physiology, Volume 108, Issue 6, Page 874-890, 1 June 2023., 2023 Abstract Tetrahydrobiopterin (BH4) is an essential cofactor for nitric oxide (NO) synthases in which its production of NO is crucial for cardiac function. However, non‐canonical roles of BH4 have been discovered recently and the cell‐specific role of cardiomyocyte BH4 in cardiac function and metabolism remains to be elucidated.
Sandy M. Chu +9 more
wiley +1 more source
Metabolic impact of adipose tissue macrophages in the early postnatal life
Journal of Leukocyte Biology, Volume 112, Issue 6, Page 1515-1524, December 2022., 2022 Graphical Abstract Macrophages in the adipose tissue affect adipocyte functioning in the early life, thereby may have a long‐term impact on obesity status. Abstract Adipose tissue macrophages (ATMs) play key roles in metabolic inflammation, insulin resistance, adipose tissue fibrosis, and immune disorders associated with obesity.
Tamás Röszer
wiley +1 more source