Results 21 to 30 of about 15,086 (118)
Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022 By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari +4 more
wiley +1 more source
Emerging Pathological Engagement of Ferroptosis in Gut Diseases
Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021 Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn’s disease, is mainly characterized by chronic and progressive inflammation that damages the gastrointestinal mucosa. Increasing studies have enlightened that dysregulated cell death occurs in the inflamed sites, leading to the disruption of the intestinal barrier and aggravating ...
Weihua Gao +3 more
wiley +1 more source
Peripheralized sepiapterin reductase inhibition as a safe analgesic therapy
Frontiers in Pharmacology, 2023 The development of novel analgesics for chronic pain in the last 2 decades has proven virtually intractable, typically failing due to lack of efficacy and dose-limiting side effects.
Shane J. F. Cronin +2 more
doaj +1 more source
Journal of Integrative Agriculture, 2023 Many different chicken breeds are found around the world, their features vary among them, and they are valuable resources. Currently, there is a huge lack of knowledge of the genetic determinants responsible for phenotypic and biochemical properties of ...
Jie WANG +8 more
doaj +1 more source
Cell & Bioscience, 2021 Background Genome editing in mice using either classical approaches like homologous recombination or CRISPR/Cas9 has been reported to harbor off target effects (insertion/deletion, frame shifts or gene segment duplications) that lead to mutations not ...
Sabrina Sailer +18 more
doaj +1 more source
Sepiapterin reductase: Characteristics and role in diseases
Journal of Cellular and Molecular Medicine, Volume 24, Issue 17, Page 9495-9506, September 2020., 2020 Abstract Sepiapterin reductase, a homodimer composed of two subunits, plays an important role in the biosynthesis of tetrahydrobiopterin. Furthermore, sepiapterin reductase exhibits a wide distribution in different tissues and is associated with many diseases, including brain dysfunction, chronic pain, cardiovascular disease and cancer.
Yao Wu +7 more
wiley +1 more source
Journal of Diabetes Research, Volume 2020, Issue 1, 2020., 2020 Objectives. Sub‐Saharan Africa (SSA) is observing an accelerating prevalence rate of type 2 diabetes mellitus (T2DM) influenced by gene‐environment interaction of modifiable and nonmodifiable factors. We conducted a systematic review and meta‐analysis on the heritability and genetic risk of T2DM in SSA. Methods.
Evans Adu Asamoah +7 more
wiley +1 more source
Role of alkylglycerol monooxygenase in Dictyostelium discoideum
, 2018 Ether lipids are found in a wide variety of organisms from bacteria to humans. A central enzyme in ether lipid metabolism is alkylglycerol monooxygenase.
Seppi, Daniele
core +3 more sources
Influence of Genetic Polymorphism Towards Pulmonary Tuberculosis Susceptibility
Frontiers in Medicine, 2018 Tuberculosis (TB) is still remains the major threat for human health worldwide. Several case-control, candidate-gene, family studies and genome-wide association studies (GWAS) suggested the association of host genetic factors to TB susceptibility or ...
Murugesan Harishankar +2 more
doaj +1 more source
Bacterial flavin-containing monooxygenase is trimethylamine monooxygenase [PDF]
, 2011 Flavin-containing monooxygenases (FMOs) are one of the most important monooxygenase systems in Eukaryotes and have many important physiological functions. FMOs have also been found in bacteria; however, their physiological function is not known.
Crombie, Andrew +15 more
core +1 more source