Adaptations of the 3T3-L1 adipocyte lipidome to defective ether lipid catabolism upon Agmo knockdown [PDF]
Journal of Lipid Research, 2022 Little is known about the physiological role of alkylglycerol monooxygenase (AGMO), the only enzyme capable of cleaving the 1-O-alkyl ether bond of ether lipids.
Katrin Watschinger +2 more
exaly +4 more sources
AGMO Inhibitor Reduces 3T3-L1 Adipogenesis [PDF]
Cells, 2021 Alkylglycerol monooxygenase (AGMO) is a tetrahydrobiopterin (BH4)-dependent enzyme with major expression in the liver and white adipose tissue that cleaves alkyl ether glycerolipids.
Irmgard Tegeder +2 more
exaly +4 more sources
When the genome bluffs: a tandem duplication event during generation of a novel Agmo knockout mouse model fools routine genotyping [PDF]
Cell and Bioscience, 2021 Background Genome editing in mice using either classical approaches like homologous recombination or CRISPR/Cas9 has been reported to harbor off target effects (insertion/deletion, frame shifts or gene segment duplications) that lead to mutations not ...
Stefan Coassin +2 more
exaly +3 more sources
The Emerging Physiological Role of AGMO 10 Years after Its Gene Identification.
Life, 2021 The gene encoding alkylglycerol monooxygenase (AGMO) was assigned 10 years ago. So far, AGMO is the only known enzyme capable of catalysing the breakdown of alkylglycerols and lyso-alkylglycerophospholipids. With the knowledge of the genetic information,
Katrin Watschinger +2 more
exaly +3 more sources
The elusive concept of sexual motivation: can it be anchored in the nervous system? [PDF]
Frontiers in Neuroscience, 2023 Sexual motivation is an abstract concept referring to the mechanisms determining the responsivity to sexually relevant stimuli. This responsivity determines the likelihood of producing a sexual response and the intensity of that response.
Elisa Ventura-Aquino, Anders Ågmo
doaj +2 more sources
Seminatural environments for rodent behavioral testing: a representative design improving animal welfare and enhancing replicability [PDF]
Frontiers in Behavioral Neuroscience, 2023 The low replicability of scientific studies has become an important issue. One possible cause is low representativeness of the experimental design employed.
Enrique Hernández-Arteaga, Anders Ågmo
doaj +2 more sources
Make or break - PEDS1 and AGMO orchestrate ether lipid homeostasis in human adipocytes and are associated with blood lipid profiles [PDF]
Journal of Translational MedicineBackground Obesity and its associated sequelae have become a major global health concern. While ester-linked lipids are well-established regulators of adipocyte function and energy storage. Emerging evidence from cohort studies suggests that ether-linked
Sabrina Sailer +9 more
doaj +2 more sources
Sexual Motivation (Desire): Problems with Current Preclinical and Clinical Evaluations of Treatment Effects and a Solution [PDF]
Behavioral SciencesThere has been an extensive search for efficient pharmacological treatment of female sexual interest/arousal disorder and other sexual dysfunctions. However, available treatments have met limited success, except for the drugs used for treating erectile ...
Anders Ågmo
doaj +2 more sources
Alkylglycerol monooxygenase represses prostanoid biosynthesis in a sex-dependent manner [PDF]
Cell & BioscienceBackground Ether lipids are important constituents of biological membranes and harbor fatty alcohols attached via ether linkages to the sn-1 position of the glycerol backbone. Depending on the nature of the ether bond, they are subdivided into 1-O-alkyl (
Zhigang Rao +10 more
doaj +2 more sources
Population structure, selection signal and introgression of gamecocks revealed by whole genome sequencing [PDF]
Journal of Animal Science and BiotechnologyBackground As an important genetic resource of chickens, gamecock has unique morphological and behavioral characteristics such as large size, muscular development and strong aggression, making it a good model for studying muscle development and behavior ...
Naiyi Xu +7 more
doaj +2 more sources