Results 31 to 40 of about 15,086 (118)

Alternative splicing of the Wnt trafficking protein, Wntless and its effects on protein-protein interactions

BMC Molecular and Cell Biology, 2019
Background Wntless (Wls) is a protein that regulates secretion of Wnt signaling molecules from Wnt-producing cells. Wnt signaling is known to be critical for several developmental and homeostatic processes.
Jessica Petko, Mathura Thileepan, Molly Sargen, Victor Canfield, Robert Levenson   +4 more
doaj   +1 more source

Endometritis and In Vitro PGE2 Challenge Modify Properties of Cattle Endometrial Mesenchymal Stem Cells and Their Transcriptomic Profile

Stem Cells International, Volume 2017, Issue 1, 2017., 2017
Mesenchymal stem cells (MSCs) were isolated and characterized from postpartum bovine endometrium of animals with subclinical (n = 5) and clinical endometritis (n = 3) and healthy puerperal females (n = 5). Cells isolated displayed mean morphological features of MSCs and underwent osteogenic, chondrogenic, and adipogenic differentiation after induction (
Evelyn Lara, Alejandra Velásquez, Joel Cabezas, Nathaly Rivera, Paulina Pacha, Lleretny Rodríguez-Alvarez, Fernando Saravia, Fidel Ovidio Castro, Luca Vanella   +8 more
wiley   +1 more source

Tetrahydrobiopterin Improves Endothelial Function in Cardiovascular Disease: A Systematic Review

Evidence-Based Complementary and Alternative Medicine, Volume 2014, Issue 1, 2014., 2014
Background. Tetrahydrobiopterin (BH4) is a cofactor of nitric oxide synthase (NOS). Nitric oxide (NO) bioavailability is reduced during the early stage of vascular diseases, such as coronary artery disease, hypercholesterolemia, hypertension, and diabetic vasculopathy, and even throughout the entire progression of atherosclerosis. Methods. A literature
Qiongying Wang, Mina Yang, Han Xu, Jing Yu, Yoshiji Ohta   +4 more
wiley   +1 more source

StyA1 and StyA2B from Rhodococcus opacus 1CP: a Multifunctional Styrene Monooxygenase System [PDF]

, 2010
Two-component flavoprotein monooxygenases are emerging biocatalysts that generally consist of a monooxygenase and a reductase component. Here we show that Rhodococcus opacus 1CP encodes a multifunctional enantioselective flavoprotein monooxygenase system
Groning, J.A.D., Michael Schlömann, Kaschabek, S.R., Dirk Tischler, Stefan R. Kaschabek, Tischler, D., Berkel, W.J.H., van, Willem J. H. van Berkel, René Kermer, Janosch A. D. Gröning, Schlomann, M., Kermer, R.   +11 more
core   +1 more source

Genome Sequence of Stenotrophomonas maltophilia PML168, Which Displays Baeyer-Villiger Monooxygenase Activity [PDF]

, 2012
Stenotrophomonas maltophilia PML168 was isolated from Wembury Beach on the English Coast from a rock pool following growth and selection on agar plates.
Muhling, M, Weynberg, KD, Mavromatis, K, Grogan, G, Nissimov, Jozef, Jensen, Chantel N., Allen, MJ, Allen, Michael J., Trivedi, Urmi, Mavromatis, Konstantinos, Tait, Karen, Jensen, C, Ali, ST, Nissimov, JI, Tait, K, Gharbi, K, Gharbi, Karim, Muehling, Martin, Bradley, Claire, Ali, Sohail T., Trivedi, U, Grogan, Gideon, Bradley, C, Weynberg, Karen   +23 more
core   +1 more source

Accumulation of ether phospholipids in induced pluripotent stem cells and oligodendrocyte‐lineage cells established from patients with Sjögren‐Larsson syndrome

Congenital Anomalies, Volume 65, Issue 1, January/December 2025.
Abstract Sjögren‐Larsson syndrome (SLS) is an autosomal recessive leukodystrophy characterized by ichthyosis, intellectual disability, and progressive spastic paralysis caused by biallelic pathogenic variants in the ALDH3A2 gene that encodes the fatty aldehyde dehydrogenase, fatty aldehyde dehydrogenase (FALDH); FALDH catalyzes several metabolic ...
Yu Yamaguchi, Hironobu Okuno, Suzumi Tokuoka, Yoshihiro Kita, Tsukasa Sanosaka, Jun Kohyama, Kenji Kurosawa, Norio Sakai, Fuyuki Miya, Takao Takahashi, Kenjiro Kosaki, Hideyuki Okano   +11 more
wiley   +1 more source

Genotypic variants of the tetrahydrobiopterin (BH4) biosynthesis genes in patients with hyperphenylalaninemia from different regions of Iran

Molecular Genetics &Genomic Medicine, Volume 12, Issue 1, January 2024.
The clinical effect of reported variants is essential for genetic counseling and prenatal diagnosis in the patients' families and significant for the improvement of precision medicine. Abstract Background Hyperphenylalaninemia (HPA) is a metabolic disorder classified into phenylalanine‐4‐hydroxylase (PAH) and non‐PAH deficiency.
Seyed Reza Kazemi Nezhad, Pegah Namdar Aligoodarzi, Golale Rostami, Gholamreza Shariati, Hamid Galehdari, Alihossein Saberi, Alireza Sedaghat, Mohammad Hamid   +7 more
wiley   +1 more source

Identification of a Novel Self-Sufficient Styrene Monooxygenase from Rhodococcus opacus 1CP. [PDF]

, 2009
Sequence analysis of a 9-kb genomic fragment of the actinobacterium Rhodococcus opacus 1CP led to identification of an open reading frame encoding a novel fusion protein, StyA2B, with a putative function in styrene metabolism via styrene oxide and ...
Schloemann, M., Eulberg, D., Kaschabek, S.R., Tischler, D., Lakner, S., Berkel, W.J.H., van   +5 more
core   +1 more source

Tetrahydrobiopterin‐dependent Alkylglycerol Monooxygenase: From Gene Identification to Novel Insights into Etherlipid Degradation

The FASEB Journal, 2011
Alkylglycerol monooxygenase is the only enzyme able to degrade alkylglycerols by cleaving the ether bond in a tetrahydrobiopterin‐dependent manner yielding a toxic aldehyde which is further oxidized by fatty aldehyde dehydrogenase. Using candidate gene expression we have recently identified the gene coding for alkylglycerol ...
Katrin Watschinger, Markus A. Keller, Georg Golderer, Martin Hermann, Albin Hermetter, Gabriele Werner‐Felmayer, Ernst R. Werner   +6 more
openaire   +1 more source

First insights into structure-function relationships of alkylglycerol monooxygenase [PDF]

, 2017
Alkylglycerol monooxygenase is a tetrahydrobiopterin-dependent enzyme that cleaves the O-alkyl-bond of alkylglycerols. It is an exceptionally unstable, hydrophobic membrane protein which has never been purified in active form.
Watschinger, Katrin, Werner, Ernst R., Keller, Markus A., Golderer, Georg, Hermetter, Albin, Hulo, Nicolas, Werner-Felmayer, Gabriele, Fuchs, Julian E., Yarov-Yarovoy, Vladimir   +8 more
core