Results 21 to 30 of about 5,611 (205)

Non-covalent interaction between polyubiquitin and GTP cyclohydrolase 1 dictates its degradation. [PDF]

PLoS ONE, 2012
GTP cyclohydrolase 1 (GTPCH1) is the rate-limiting enzyme in the de novo synthesis of tetrahydrobiopterin (BH4). GTPCH1 protein degradation has been reported in animal models of several diseases, including diabetes mellitus and hypertension. However, the
Yu Zhao, Huaiping Zhu, Ming-Hui Zou
doaj   +1 more source

Identification of proteins interacting with GTP cyclohydrolase I [PDF]

Biochemical and Biophysical Research Communications, 2009
GTP cyclohydrolase I (GCH-1) is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, an essential cofactor for nitric oxide synthase and aromatic amino acid hydroxylase. To explore the interactome of GCH-1, we established a HEK 293 cell line stably expressing tetracycline-inducible FLAG-GCH-1.
Jianhai, Du, Hao, Xu, Na, Wei, Bassam, Wakim, Brian, Halligan, Kirkwood A, Pritchard, Yang, Shi   +6 more
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Do genetic predictors of pain sensitivity associate with persistent widespread pain? [PDF]

, 2009
Genetic risk factors for pain sensitivity may also play a role in susceptibility to chronic pain disorders, in which subjects have low pain thresholds.
Nicholl Barbara I, McBeth John, Davies, K.A., Macfarlane, Gary J., John McBeth, Holliday, K.L., Kate L Holliday, Nicholl, Barbara I., Thomson, W., Macfarlane, G.J., Thomson Wendy, Nicholl, B.I, Davies Kelly A, McBeth, J., Holliday, Kate L., McBeth, John, Wendy Thomson, Kelly A Davies, Macfarlane Gary J, Holliday Kate L, Thomson, Wendy, Gary J Macfarlane, Barbara I Nicholl, Davies, Kelly A.   +23 more
core   +1 more source

RibBX of Bradyrhizobium ORS285 Plays an Important Role in Intracellular Persistence in Various Aeschynomene Host Plants

Molecular Plant-Microbe Interactions, 2021
Bradyrhizobium ORS285 forms a nitrogen-fixating symbiosis with both Nod factor (NF)-dependent and NF-independent Aeschynomene spp. The Bradyrhizobium ORS285 ribBA gene encodes for a putative bifunctional enzyme with 3,4-dihydroxybutanone phosphate (3,4 ...
Nico Nouwen, Jean-Francois Arrighi, Djamel Gully, Eric Giraud   +3 more
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Cytokines Stimulate GTP Cyclohydrolase I Gene Expression in Cultured Human Umbilical Vein Endothelial Cells [PDF]

, 1998
—In vascular endothelial cells, tetrahydrobiopterin serves as an essential cofactor required for enzymatic activity of nitric oxide synthase. GTP cyclohydrolase I is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin.
Zvonimir S. Katusic, Sheldon Milstien, Adele Stelter   +2 more
core   +1 more source

Characterization of mouse and human GTP cyclohydrolase I genes. Mutations in patients with GTP cyclohydrolase I deficiency.

The Journal of biological chemistry, 1995
GTP cyclohydrolase I is the first and rate-limiting enzyme for the biosynthesis of tetrahydrobiopterin in mammals. Previously, we reported three species of human GTP cyclohydrolase I cDNA in a human liver cDNA library (Togari, A., Ichinose, H., Matsumoto, S., Fujita, K., and Nagatsu, T. (1992) Biochem. Biophys. Res. Commun. 187, 359-365).
Ichinose H, Ohye T, Matsuda Y, Hori T-A, Blau N, Burlina A, Rouse B, Matalon R, Fujita K, Nagatsu T   +9 more
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Homology Cloning of GTP-cydohydrolase I from Fungi and Plants by Reverse-transcription PCR Using a General Set of Degenerate Primers

Pteridines, 1995
Unconjugated pteridines are present in fungi, algae and plants. However, the functions of pteridines in these organisms are not thoroughly investigated. The biosynthesis follows the same steps as were shown for animals and eubacteria.
Maier Josef, Werner Thomas, Ninnemann Helga   +2 more
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GTP cyclohydrolase I utilizes metal‐free GTP as its substrate [PDF]

European Journal of Biochemistry, 2003
GTP cyclohydrolase I (GCH) is the rate‐limiting enzyme for the synthesis of tetrahydrobiopterin and its activity is important in the regulation of monoamine neurotransmitters such as dopamine, norepinephrine and serotonin. We have studied the action of divalent cations on the enzyme activity of purified recombinant human GCH expressed in Escherichia ...
T. Suzuki, H. Kurita, H. Ichinose
openaire   +2 more sources

Molecular characterization of HPH-1: a mouse mutant deficient in GTP cyclohydrolase I activity [PDF]

, 1994
Click on the DOI link to access the article (may not be free).GTP cyclohydrolase I catalyzes the initial and rate limiting step of the biosynthesis of tetrahydrobiopterin, the cofactor for aromatic amino acid hydroxylation.
Witter, K., Hultner, L., Ziegler, I., Gutlich, M., Werner, T., Bacher, A., Hemmens, B., McDonald, J. David, Rodl, W.   +8 more
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A systematic map of genetic variation in Plasmodium falciparum.

PLoS Pathogens, 2006
Discovering novel genes involved in immune evasion and drug resistance in the human malaria parasite, Plasmodium falciparum, is of critical importance to global health.
Claire Kidgell, Sarah K Volkman, Johanna Daily, Justin O Borevitz, David Plouffe, Yingyao Zhou, Jeffrey R Johnson, Karine Le Roch, Ousmane Sarr, Omar Ndir, Soulyemane Mboup, Serge Batalov, Dyann F Wirth, Elizabeth A Winzeler   +13 more
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