Results 41 to 50 of about 5,611 (205)

Complementation of the fol2 deletion in Saccharomyces cerevisiae by human and Escherichia coli genes encoding GTP cyclohydrolase I [PDF]

, 1999
Saccharomyces cerevisiae is so far the only organism where a knock-out mutant in the gene encoding GTP cyclohydrolase I (FOL2) has been obtained. GTP cycloydrolase I controls the de novo biosynthetic pathway of tetrahydrobiopterin and folic acid.
A. Bracher, G. Buscemi, A. Bacher, M. Gütlich, F. Saracino, N. Schramek, R. Mancini, M. Fischer, M. L. Carbone   +8 more
core   +1 more source

Comparative Genomic Analysis of the DUF34 Protein Family Suggests Role as a Metal Ion Chaperone or Insertase

Biomolecules, 2021
Members of the DUF34 (domain of unknown function 34) family, also known as the NIF3 protein superfamily, are ubiquitous across superkingdoms. Proteins of this family have been widely annotated as “GTP cyclohydrolase I type 2” through electronic ...
Colbie J. Reed, Geoffrey Hutinet, Valérie de Crécy-Lagard   +2 more
doaj   +1 more source

Double Transduction with GTP Cyclohydrolase I and Tyrosine Hydroxylase Is Necessary for Spontaneous Synthesis ofl-DOPA by Primary Fibroblasts [PDF]

, 1996
Gene transfer of tyrosine hydroxylase (TH) in animal models of Parkinson’s disease (PD), using either genetically modified cells or recombinant virus vectors, has produced partial restoration of behavioral and biochemical deficits. The limited success of
Kazuyuki Hatakeyama, Craig Bencsics, Un Jung Kang, Stephen R. Wachtel, Sheldon Milstien, Jill B. Becker   +5 more
core   +1 more source

Insulin Stimulates Tetrahydrobiopterin Synthesis in Mouse Brain Microvascular Endothelial Cells

Pteridines, 1999
We examined the effects of insulin on tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells (MBMECs). Treatment of MBMECs with insulin increased the intracellular BH4 content in a time- and concentration-dependent manner. The
Ishi Masakazu, Shimizu Shunichi, Nagai Tsutomu, Kiuchi Yuji, Yamamoto Toshinori   +4 more
doaj   +1 more source

Melanisation of teladorsagia circumcincta larvae exposed to sunlight: a role for GTP-Cyclohydrolase in nematode survival [PDF]

, 2012
Pre-parasitic stage larvae of a number of parasitic nematodes express high levels of the enzyme GTP-Cyclohydrolase I (GTP-CH). C. elegans mutants which are GTP-CH deficient have low levels of cuticualr melanin and show increased sensitivity to ...
Baker, R.H., Matthews, J.B., Nisbet, A.J., Britton, C., Roberts, B., Loer, C.M.   +5 more
core   +1 more source

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, EarlyView.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

GTP-Cyclohydrolase function in parasitic nematode development [PDF]

, 2012
Parasitic nematodes of grazing livestock represent an increasing economic and welfare problem for British agriculture. By investigating specific life-cycle stages of these parasites, it may be possible to identify key molecules or pathways that are ...
Baker, Rachael Helen
core  

Observations on an Open‐Label Phase 1/2 Dopamine Gene Therapy Trial (OXB‐102/Axo‐Lenti‐PD) in People with Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background SUNRISE‐PD was a dose‐escalating, phase 1/2 study investigating a second‐generation lentiviral vector gene therapy delivering the genes for dopamine synthesis (OXB‐102) to treat Parkinson's disease (PD). The trial was prematurely terminated due to insolvency of the sponsor.
Simon Rowe, Amy Evans, Saeed Kayhanian, Philip C. Buttery, Robert Morris, Katie Andresen, Laura Sherlock, Samuel Hewitt, Tagore Nakornchai, Marwan Hariz, Kyriacos Mitrophanous, Ludvic Zrinzo, Matthew Appleby, Phil Woodgate, Seema Maru, Patricia Limousin, Christine Girges, Thomas Foltynie, Stephane Palfi, Roger A. Barker   +19 more
wiley   +1 more source

Rat GTP cyclohydrolase I is a homodecameric protein complex containing high-affinity calcium-binding sites [PDF]

, 1998
Recombinant rat liver GTP cyclohydrolase I has been prepared by heterologous gene expression in Escherichia coli and characterized by biochemical and biophysical methods.
Aebi, U., Werner, Ernst R., Steinmetz, Michel O., Christen, Urs, Wolpensinger, Bettina, Kammerer, Richard A., Wachter, H., Aebi, Ueli, Engel, Andreas, Werner, E. R., Christen, U., Lustig, A., Engel, A., Kammerer, R. A., Steinmetz, M. O., Plüss, Christoph, Lustig, Ariel, Pluss, C., Wolpensinger, B., Pfeilschifter, Josef, Wachter, Helmut, Pfeilschifter, J.   +21 more
core   +1 more source

Reconfiguring biofortification strategies to transform food systems and address micronutrient deficiency of the 21st century

Journal of Integrative Plant Biology, EarlyView.
This review explores how to make staple foods and horticultural crops more nutritious, including how artificial intelligence‐based screening of gene banks helps deploy nutritionally rich germplasm into breeding. Genome editing can help develop crops richer in minerals, vitamins, and health‐promoting compounds, supporting healthier diets and more ...
Rhowell Jr. N. Tiozon, Alisdair R. Fernie, Nese Sreenivasulu   +2 more
wiley   +1 more source