Results 51 to 60 of about 5,611 (205)

Functional Studies on the Promoter Region of the Human GTP Cyclohydrolase I Gene

Pteridines, 1995
We have isolated genomic clones that contained the gene for human GTP cyclohydrolase I. One clone containing the 5'-regulatory region of this gene was further analysed.
Gütlich Markus, Witter Klaus, Katzenmeier Gerd, Rödl Wolfgang, Wernert Thomas, Ziegler Irmgard, Bacher Adelbert   +6 more
doaj   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Stimulation of Tetrahydrobiopterin Synthesis by Basic Fibroblast Growth Factor in Vascular Endothelial Cells

Pteridines, 2003
The purpose of this study was to examine whether basic fibroblast growth factor (bFGF) stimulates tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells.
Shimizu Shunichi, Miyasaka Yoshiyuki, Yamamoto Shinichiro, Ishii Masakazu, Kiuchi Yuji   +4 more
doaj   +1 more source

Relationship Between Central Sensitization and Genetic Polymorphisms—A Case–Control Study in Fibromyalgia

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian, Christian Dualé, Marine Delay, Vincent Leray, Bruno Pereira, Yoan Renaud, Yvonne Gloor, Jules Desmeules, Gisèle Pickering   +8 more
wiley   +1 more source

Regulation of GTP cyclohydrolase I gene transcription by basic region leucine zipper transcription factors [PDF]

, 2005
Tetrahydrobiopterin is an essential cofactor for the phenylalanine, tyrosine and tryptophan hydroxylases, and the family of nitric oxide synthases. The initial and rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin is GTP cyclohydrolase 1 ...
Vinson, C., Al Sarraj, J., 韩家淮, Han, J. H., Thiel, G.   +4 more
core  

Influences of Catecholamine Contents on Tetrahydrobiopterin Metabolism

Pteridines, 1998
The influence of changes in catecholamine metabolism on tetrahydrobiopterin biosynthesis was investigated in cultured rat pheochromocytoma PC12 cells. The increase in the cellular dopamine content after treatment with the MAO-COMT inhibitor or dopamine ...
Kuzuya Hiroshi, Sakamoto Hideo, Fujita Ko   +2 more
doaj   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

6-Acetyldihydrohomopterin and sepiapterin affect some GTP cyclohydrolase I's and not others [PDF]

, 1988
The first enzyme in pteridine biosynthesis, GTP cyclohydrolase I, is a likely site for regulation of pteridine biosynthesis to occur. GTP cyclohydrolase I responds to hormonal treatment and is found altered in a variety of mice with genetically based ...
Jacobson, K. Bruce, Manos, Richard E.
core  

Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures [PDF]

, 2011
Background: Various effects on pain have been reported with respect to their statistical significance, but a standardized measure of effect size has been rarely added.
Karin Flühr, Doehring Alexandra, Flühr, Karin, Küsener, Nele, Jörn Lötsch, Doehring, Alexandra, Küsener Nele, Alexandra Doehring, Flühr Karin, Nele Küsener, Till J Neddermeyer, Lötsch Jörn, Neddermeyer, Till, Lötsch, Jörn, Neddermeyer Till J., Schneider, Gaby, Till J. Neddermeyer, Gaby Schneider, Schneider Gaby   +18 more
core   +1 more source

Troglitazone Stimulates the Insulin-induced Tetrahydrobiopterin Synthesis In Vascular Endothelial Cells

Pteridines, 2000
We investigated the effects of troglitazone, which is a ligand of nuclear transcription factor peroxisome proliferator- activated receptor-γ (PPAR-γ), on insulin-induced tetrahydrobiopterin (BH4) synthesis in mouse brain microvascular endothelial cells ...
Ishii Masakazu, Shimizu Shunichi, Shiota Kazuhiro, Kiuchi Yuji, Yamamoto Toshinori   +4 more
doaj   +1 more source