Results 251 to 260 of about 73,799 (301)

Clinical Evaluation of Potential Interaction Between Bemnifosbuvir and Ruzasvir With an Assessment of Food Effect: Results of a Phase 1 Study in Healthy Participants. [PDF]

Clin Pharmacol Drug Dev
Zhou XJ, Morelli G, Montrond M, Lynch S, Pietropaolo K, Belanger B, Horga A, Hammond J.   +7 more
europepmc   +1 more source

Mechanism of Inhibition of the Active Triphosphate Form of 2'-α-Fluoro,2'-β-bromouridine against Yellow Fever Virus RNA-Dependent RNA Polymerase. [PDF]

ACS Infect Dis
Gordon CJ, Walker SM, LeCher JC, Amblard F, Schinazi RF, Götte M.   +5 more
europepmc   +1 more source

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Interactions of tubulin with vinblastine and guanosine triphosphate

Journal of Molecular Biology, 1972
Abstract Tubulin isolated from calf brain contains one mole of tightly bound nucleotide per 120,000 g of protein, chiefly as GDP. Another mole of GTP can be bound in exchange with the medium. Transphosphorylation occurs between the terminal phosphate of the exchangeable nucleotide and the tightly bound GDP.
Robert W. Berry, Robert W. Berry, Michael L. Shelanski, Michael L. Shelanski   +3 more
openaire   +3 more sources

Preparative Enzymatic Conversion of Guanosine-5′ -monophosphate to Guanosine-5′ - triphosphate [PDF]

Synlett, 1990
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Regine Stiller, Joachim Thiem
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Synthesis of Guanosine-Containing Dinucleoside Triphosphates

Advanced Materials Research, 2014
Dinucleoside polyphosphates have potential medicinal value and are of substantial interest to both synthetic and medicinal chemists. A practical method for the synthesis of guanosine-containing asymmetrical dinucleoside triphosphates (Gp3C and Gp3U) with 4,5-dicyanoimidazole as activator has been developed.
Yue Hai You, Qi Sun, Shan Shan Gong
openaire   +2 more sources

Repetitive recycling of guanosine triphosphate cyclohydrolase I for synthesis of dihydroneopterin triphosphate

Analytical Biochemistry, 1989
A procedure for enzymatic production of dihydroneopterin triphosphate is described that allows GTP cyclohydrolase I to be reused repetitively. The reaction takes place in an ultrafiltration cell, and the product is collected in the filtrate, whereas the enzyme remains in the cell to be reused with additional substrate. This is repeated until the enzyme
Edwin W. Naylor, K. Bruce Jacobson, Juan Ferré   +2 more
openaire   +3 more sources

Controlling Supramolecular Fiber Formation of Nucleopeptide by Guanosine Triphosphate

Biomacromolecules, 2023
Cells use dynamic self-assembly to construct functional structures for maintaining cellular homeostasis. However, using a natural biological small molecule to mimic this phenomenon remains challenging. This work reports the dynamic microfiber formation of nucleopeptide driven by guanosine triphosphate, the small molecule that controls microtubule ...
Hongyue Zhang, Tengyan Xu, Juan Liang, Bihan Wu, Xuejiao Yang, Jing Wang, Ziao Zhou, Huaimin Wang   +7 more
openaire   +2 more sources

Direct photoaffinity labeling of tubulin with guanosine 5'-triphosphate

Biochemistry, 1985
Irradiation of tubulin in the presence of [3H]GTP or [3H]GDP at 254 nm led to the covalent incorporation of nucleotide into the protein. The specific nature of the labeling was shown in the following manner: with tubulin depleted of exchangeable nucleotide, the amount of labeling increased to a plateau value as the [3H]GTP concentration was increased ...
Richard H. Himes, Geoffrey R. Eagle, Jyoti P. Nath   +2 more
openaire   +3 more sources

[37] Guanosine triphosphate-8-formylhydrolase

1975
Publisher Summary This chapter discusses the assay and purification procedure of guanosine triphosphate-8-formylhydrolase. The assay method is based on two procedures. The first method involves the release of 14 C-labeled formic acid from carbon-8 of the imidazole ring of [8- 14 C]GTP. The formic acid is oxidized to carbon dioxide. The second method
R.J. Suhadolnik, E.F. Elstner
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Preparative method of obtaining guanosine 5′-triphosphate

Chemistry of Natural Compounds, 1965
1. The kinetics of the formation of guanosine 5′-triphosphate, 5′-diphosphate, and 5′-monophosphate in the reaction of the morpholide of guanosine 5′-monophosphate with bis-(tributylammonium) pyrophosphate in pyridine at 27° has been recorded. 2. In the reaction of the morpholide of guanosine 5′-monophosphate with bis-(tributylammonium) pyrophosphate ...
T. S. Lomakina, N. I. Grineva
openaire   +2 more sources