Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels [PDF]
, 2001 Cyclic adenosine monophosphate and cyclic guanosine monophosphate are universal intracellular messengers whose concentrations are regulated by molecular networks comprised of different isoforms of the synthases adenylate cyclase or guanylate cyclase and ...
A Dietz +22 more
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The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia. [PDF]
, 2018 Guanylate cyclase C (GUCY2C) is a transmembrane receptor expressed on the luminal aspect of the intestinal epithelium. Its ligands include bacterial heat-stable enterotoxins responsible for traveler\u27s diarrhea, the endogenous peptide hormones ...
Rappaport, Jeffrey A., Waldman, Scott A.
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The Universally Conserved Unconventional G Protein YchF Is Critical for Growth and Stress Response
Life, 2023 The ancient guanine nucleotide-binding (G) proteins are a group of critical regulatory and signal transduction proteins, widely involved in diverse cellular processes of all kingdoms of life. YchF is a kind of universally conserved novel unconventional G
Zhaoheng Lin +7 more
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Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]
, 2013 © 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P +8 more
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Transient disappearance of RAS mutant clones in plasma: A counterintuitive clinical use of EGFR inhibitors in RAS mutant metastatic colorectal cancer [PDF]
, 2019 Genomic studies performed through liquid biopsies widely elucidated the evolutionary trajectory of RAS mutant clones under the selective pressure of EGFR inhibitors in patients with wild type RAS primary colorectal tumors. Similarly, the disappearance of
Belardinilli, Francesca +9 more
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Clinical Interventions in Aging, 2023 Barbara Pospieszna,1 Krzysztof Kusy,1 Ewa Maria Slominska,2 Monika Ciekot-Sołtysiak,1 Jacek Zieliński1 1Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland; 2Department of Biochemistry,
Pospieszna B +4 more
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The dynamic structure of Rab35 is stabilized in the presence of GTP under physiological conditions
Biochemistry and Biophysics Reports, 2020 Rab proteins, a family of small guanosine triphosphatases, play key roles in intracellular membrane trafficking and the regulation of various cellular processes.
Takuya Murata +3 more
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Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells. [PDF]
, 2015 The treatment of myocardial infarction is a major challenge in medicine due to the inability of heart tissue to regenerate. Direct reprogramming of endogenous cardiac fibroblasts into functional cardiomyocytes via the delivery of transcription factor ...
Kim, Hyun Jin +5 more
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Metformin induces distinct bioenergetic and metabolic profiles in sensitive versus resistant high grade serous ovarian cancer and normal fallopian tube secretory epithelial cells. [PDF]
, 2017 Metformin is a widely used agent for the treatment of diabetes and infertility, however, it has been found to have anti-cancer effects in a variety of malignancies including high grade serous ovarian cancer (HGSC).
Aspuria, Paul-Joseph P +6 more
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Roles of Rap1 signaling in tumor cell migration and invasion
Cancer Biology & Medicine, 2017 Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization.
Yi-Lei Zhang +4 more
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