Results 41 to 50 of about 159,662 (351)
Dynamics of Microtubule Instabilities [PDF]
J. Stat. Mech. (2007) L05004, 2007 We investigate the dynamics of an idealized model of microtubule growth that evolves by: (i) attachment of guanosine triphosphate (GTP) at rate lambda, (ii) conversion of GTP to guanosine diphosphate (GDP) at rate 1, and (iii) detachment of GDP at rate mu. As a function of these rates, a microtubule can grow steadily or its length can fluctuate wildly.
arxiv +1 more source
RhoB regulates cell migration through altered focal adhesion dynamics [PDF]
Open Biology, 2012 The Rho GTPase RhoB has been shown to affect cell migration, but how it does this is not clear. Here we show that cells depleted of RhoB by RNAi are rounded and have defects in Rac-mediated spreading and lamellipodium extension, although they have active
Francisco M. Vega +4 more
doaj +1 more source
Interlinked GTPase cascades provide a motif for both robust switches and oscillators [PDF]
J. R. Soc. Interface 16, 20190198 (2019), 2019 GTPases regulate a wide range of cellular processes, such as intracellular vesicular transport, signal transduction, and protein translation. These hydrolase enzymes operate as biochemical switches by toggling between an active guanosine triphosphate (GTP)-bound state and an inactive guanosine diphosphate (GDP)-bound state.
arxiv +1 more source
Journal of Physical Chemistry B, 2015 Molecular mechanisms of the hydrolysis of guanosine triphosphate (GTP) to guanosine diphosphate (GDP) and inorganic phosphate (Pi) by the Ras·GAP protein complex are fully investigated by using modern modeling tools. The previously hypothesized stages of
M. Khrenova +3 more
semanticscholar +1 more source
Organic and biomolecular chemistry, 2014 The light-driven artificial enzymes were constructed to realize unnatural reactions concerning bio-significant molecules. In this manuscript, the guanosine triphosphate (GTP)-selective oxidation is reported using the network polymers composed of ...
Jonghwan Jeon, Kazuo Tanaka, Y. Chujo
semanticscholar +1 more source
Role of ARHGEF3 as a GEF and mTORC2 Regulator
Frontiers in Cell and Developmental Biology, 2022 Guanine nucleotide exchange factors (GEFs) activate GTPases by stimulating the release of guanosine diphosphate to permit the binding of guanosine triphosphate.
Sana Abdul Khaliq +5 more
doaj +1 more source
A thermodynamic paradigm for solution demixing inspired by nuclear transport in living cells [PDF]
Phys. Rev. Lett. 118, 158101 (2017), 2016 Living cells display a remarkable capacity to compartmentalize their functional biochemistry. A particularly fascinating example is the cell nucleus. Exchange of macromolecules between the nucleus and the surrounding cytoplasm does not involve traversing a lipid bilayer membrane.
arxiv +1 more source
Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]
, 2013 Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Birkás, Erika +12 more
core +3 more sources
Effect of GTP and Ca2+ on inositol 1,4,5-trisphosphate induced Ca2+ release from permeabilized rat exocrine pancreatic acinar cells [PDF]
, 1991 The effects of Ca2+ and GTP on the release of Ca2+ from the inositol 1,4,5-trisphosphate (IP3) sensitive Ca2+ compartment were investigated with digitonin permeabilized rat pancreatic acinar cells.
Ammann +30 more
core +1 more source
Non-invasive force measurement reveals the number of active kinesins on a synaptic vesicle precursor in axonal transport regulated by ARL-8 [PDF]
Physical Chemistry Chemical Physics 20, 3403-3410 (2018), 2018 Kinesin superfamily protein UNC-104, a member of the kinesin-3 family, transports synaptic vesicle precursors (SVPs). In this study, the number of active UNC-104 molecules hauling a single SVP in axons in the worm Caenorhabditis elegans was counted by applying a newly developed non-invasive force measurement technique.
arxiv +1 more source