Results 61 to 70 of about 97,251 (205)

Guanosine Triphosphate and Uridine Triphosphate from Muscle. [PDF]

Acta Chemica Scandinavica, 1953
Rolf Bergkvist, Adam Deutsch, John Olsen, Artturi I. Virtanen, Nils Andreas Sörensen   +4 more
openaire   +1 more source

Cardiotoxicity of BRAF/MEK inhibitors

British Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe, Valerie Lohner, Kevin Terre, Thomas Riffelmacher, Roman Pfister   +4 more
wiley   +1 more source

Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer. [PDF]

J Clin Invest, 2021
Huang F, Huffman KE, Wang Z, Wang X, Li K, Cai F, Yang C, Cai L, Shih TS, Zacharias LG, Chung A, Yang Q, Chalishazar MD, Ireland AS, Stewart CA, Cargill K, Girard L, Liu Y, Ni M, Xu J, Wu X, Zhu H, Drapkin B, Byers LA, Oliver TG, Gazdar AF, Minna JD, DeBerardinis RJ.   +27 more
europepmc   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Identification of the mixed Dicleotide-Polyphosphate Adenosine-Guanosine- Triphosphate from bovine suprarenal gland

, 2010
Der essentielle Bluthochdruck ist in seiner Genese noch nicht hinreichend geklärt. Es gibt eine Vielzahl verschiedener Ansätze, die Ursachen des Bluthochdrucks zu erforschen und Mediatoren zu identifizieren, die den Blutdruck beeinflussen.
Meyer-Hilse, Frank
core   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Delineation of molecular interactions of plant growth promoting bacteria induced β-1,3-glucanases and guanosine triphosphate ligand for antifungal response in rice: a molecular dynamics approach. [PDF]

Mol Biol Rep, 2022
Jha Y, Dehury B, Kumar SPJ, Chaurasia A, Singh UB, Yadav MK, Angadi UB, Ranjan R, Tripathy M, Subramanian RB, Kumar S, Simal-Gandara J.   +11 more
europepmc   +1 more source

Amplification and cloning of guanosine 5'-triphosphate, 3'- diphosphate phosphohydrolase enzyme from Mycobacterium tuberculosis

, 2020
Mycobacterium tuberculosis, the etiological agent of human tuberculosis (TB), is one of the most successful bacterial pathogens, remaining a leading cause of morbidity and mortality.
Bruno Lopes Abbadi, Luiz Augusto Basso, Diógenes Santiago Santos, Zilpa Adriana Sánchez Quitian   +3 more
core  

Exocytosis from permeabilized bovine adrenal chromaffin cells is differently modulated by guanosine 5'-[gamma-thio]triphosphate and guanosine 5'-[beta gamma-imido]triphosphate [PDF]

, 1992
1. In bovine adrenal chromaffin cells made permeable either to molecules less than or equal to 3 kDa with alphatoxin or to proteins less than or equal to 150 kDa with streptolysin O, the GTP analogues guanosine 5'-[beta gamma-imido]triphosphate (p[NH]ppG)
Rosenthal, W., Ahnert-Hilger, G., Wegenhorst, U., Gratzl, Manfred, Stecher, B., Spicher, K.   +5 more
core   +1 more source

Thermodynamic characterisation of covalent ligand binding

British Journal of Pharmacology, EarlyView.
Background and Purpose Differential scanning fluorimetry (DSF) is a common and straightforward method to evaluate the thermal stability of proteins and has been heavily used for ligand binding characterisation as well as for screening. One class of compounds that is less typically evaluated by DSF are covalent binders.
Rebecca Hertzman, Maayan Lavie, Almog Nadir, Ronen Gabizon, Nir London   +4 more
wiley   +1 more source