Results 81 to 90 of about 97,251 (205)

Evaluation of the in vitro quality of X‐ray irradiated red cell concentrates processed and stored using di(2‐ethylhexyl) terephthalate plasticized blood bag sets

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Polyvinyl chloride (PVC) blood bags plasticized with di(2‐ethylhexyl) phthalate (DEHP) have long been the standard for red blood cell (RBC) storage. Due to safety concerns, alternatives like di(2‐ethylhexyl) terephthalate (DEHT), in combination with next‐generation additive solutions like phosphate‐adenine‐glucose ...
Carly Olafson, Sanaz Hemmatibardehshahi, Geraldine M. Walsh, Anita Howell   +3 more
wiley   +1 more source

Impact of additive solutions on haematocrit measurement and red blood cell integrity: A comparative study of SAGM and PAGGSM

Vox Sanguinis, EarlyView.
Abstract Background and Objectives Accurate haematocrit (Ht) measurement of red cell concentrates (RCCs) is critical because it is used to calculate the level of haemolysis, a key RCC quality control parameter. The hypothesis was that Ht depends on both the measurement method (microcapillary vs.
Anaïs Lagrange, Nadine Marpaux, Pascal Amireault, Michael Dussiot, Quentin Brebant   +4 more
wiley   +1 more source

Hydrolysis of Guanosine Triphosphate (GTP) by the Ras·GAP Protein Complex: Reaction Mechanism and Kinetic Scheme

, 2015
Molecular mechanisms of the hydrolysis of guanosine triphosphate (GTP) to guanosine diphosphate (GDP) and inorganic phosphate (Pi) by the Ras·GAP protein complex are fully investigated by using modern modeling tools. The previously hypothesized stages of
Maria G. Khrenova (1344948), Anatoly B. Kolomeisky (1340823), Bella L. Grigorenko (1515202), Alexander V. Nemukhin (1295805)   +3 more
core   +1 more source

Maternal protein restriction programs the ageing kidney: Proteomic signatures of early‐life origin renal and metabolic dysfunction

The Journal of Physiology, EarlyView.
Abstract figure legend Maternal protein restriction (MPR) induced persistent renal histopathological alterations accompanied by elevated serum creatinine levels. Nephron‐segment proteomic analysis revealed region‐specific molecular dysregulation affecting Bowman's capsule (PARK7, oxidative stress sensor; MSN, cytoskeletal organization), the proximal ...
Marina Pereira Pires, Matheus Naia Fioretto, Marcel Rodrigues Ferreira, Isabelle Tenori Ribeiro, Luísa Annibal Barata, Flávia Alessandra Maciel, Lucas Sobrinho Lemos, Renato Mattos, Luiz Marcos Frediane Portela, Patrick Vieira de Souza, Luisa Correia Gomes, Gustavo Monezzi Cordeiro, Wellerson Rodrigo Scarano, Patrícia Aline Boer, Jose Antonio Rocha Gontijo, Luis Antonio Justulin   +15 more
wiley   +1 more source

Resolution and Quantitation of Ribonucleosides and Deoxyribonucleosides in Digested Genomic DNA by UHPLC–MS/MS

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT Deoxyuridine (dUrd) is often misincorporated into genomic DNA in cancer patients receiving antimetabolite chemotherapy. This activates base excision repair and recruits ataxia telangiectasia‐mutated and Rad3‐related (ATR), which coordinates DNA repair with nucleotide metabolism by facilitating ribonucleotide reductase (RNR) activity ...
Joshua J. Deppas, Reyna Jones, Robert A. Parise, Pinakin Pandya, Christopher J. Bakkenist, Jan H. Beumer   +5 more
wiley   +1 more source

Role of Tissue Transglutaminase Catalytic and Guanosine Triphosphate-Binding Domains in Renal Cell Carcinoma Progression. [PDF]

ACS Omega, 2020
Ulukan B, Bihorac A, Sipahioglu T, Kiraly R, Fesus L, Telci D.   +5 more
europepmc   +1 more source

Guanosine Triphosphate [PDF]

, 2020
openaire   +1 more source

The mechanism of guanosine nucleotide hydrolysis by p21 c-Ha-ras. The stereochemical course of the GTPase reaction

, 1989
The use of guanosine 5'-O-(gamma-thio)triphosphate as a substrate for p21 c-Ha-ras was established. By using chirally labeled [gamma-17O,18O]guanosine 5'-O-(gamma-thio)triphosphate, the stereochemical course of the GTPase reaction was determined.
Webb, M., Feuerstein, J., Goody, R.
core   +1 more source

Variant‐Specific Landscape of Mutual Exclusivity Among BRAF, EGFR, and KRAS Oncogenes Reveals Overlap With Functionally Antagonistic Mutant Pairs

International Journal of Cancer, Volume 159, Issue 7, Page 1715-1734, 1 October 2026.
Mutual exclusivity and co‐occurrence of oncogenic mutations reflect functional antagonism or dependence and may inform therapeutic strategies. However, most studies overlook variant‐level patterns. In this comprehensive, cross‐cohort analysis of BRAF, KRAS, and EGFR mutation subtypes, the most significant mutual exclusivity pairs overlapped with ...
Freya Vaeyens, Jan‐Patrick Hetzel, Khaldoon Abdullah, Carolien Eggermont, Catharina Olsen, Marco Mernberger, Ken Maes, Jelle Vlaeminck, Rainer Claus, Dries Vanisterbecq, Frederik Hes, Martin Pichler, Philippe Giron, Oleg Timofeev, Maxim Noeparast   +14 more
wiley   +1 more source

OXIDATIVE STRESS AND THE GUANOSINE NUCLEOTIDE TRIPHOSPHATE POOL: IMPLICATIONS FOR A BIOMARKER AND MECHANISM OF IMPAIRED CELL FUNCTION [PDF]

, 2008
Oxidation of the guanosine (G) moiety, yielding the oxidized lesion 8-hydroxy-2\u27-deoxyguanosine (oxo82dG), in DNA has become a hallmark biomarker in assessing cellular outcomes induced by oxidative stress.
Bolin, Celeste Maree
core