Results 61 to 70 of about 159,662 (351)

The synthesis of 2′-methylseleno adenosine and guanosine 5′-triphosphates

Bioorganic & Medicinal Chemistry, 2012
Modified nucleoside triphosphates (NTPs) represent powerful building blocks to generate nucleic acids with novel properties by enzymatic synthesis. We have recently demonstrated the access to 2'-SeCH(3)-uridine and 2'-SeCH(3)-cytidine derivatized RNAs for applications in RNA crystallography, using the corresponding nucleoside triphosphates and distinct
Santner, Tobias, Micura, Ronald, Siegmund, Vanessa, Marx, Andreas   +3 more
openaire   +4 more sources

Glucocorticoids and the regulation of phosphoenolpyruvate carboxykinase (guanosine triphosphate) in the rat [PDF]

Biochemical Journal, 1975
The effect glucocorticoids on the synthesis and degradation of phosphoenolpyruvate carboxykinase (GTP)(EC4.1.1.32) in rat liver and kidney in vivo was studied immunochemically. The glucocorticoid analogue triamcinolone (9α-fluoro-11β, 21-dihydroxy-16α,17α-isopropylidenedioxypregna-1,4-diene-3,20-dione) increased the synthesis rate of the kidney enzyme ...
Lea Reshef, O Meyuhas, J M Gunn, Richard W. Hanson, F.J. Ballard   +4 more
openaire   +3 more sources

Dinucleoside polyphosphates : newly detected uraemic compounds with an impact on leucocyte oxidative burst [PDF]

, 2009
Background. Dinucleoside polyphosphates (NpnN) have pathophysiologic roles in cardiovascular disease and are newly detected uraemic retention solutes. They were retrieved in human plasma, tissues and cells.
Dhondt, Annemieke, Glorieux, Griet, Jankowski, Joachim, Jankowski, Vera, Schepers, Eva, Vanholder, Raymond   +5 more
core   +1 more source

Understanding and treating ejaculatory dysfunction in men with diabetes mellitus

Andrology, Volume 11, Issue 2, Page 379-398, February 2023., 2023
Abstract Diabetes mellitus is a rapidly rising metabolic disorder with important systemic complications. Global figures have demonstrated the prevalence of diabetes mellitus has almost quadrupled from 108 million in 1980 to 422 million in 2014, with a current prevalence of over 525 million.
Ankit Desai, Runzhi Chen, Axel Cayetano, Channa N. Jayasena, Suks Minhas   +4 more
wiley   +1 more source

New Transferrin Receptor‐Targeting Conjugate Effectively Delivers DNA to Mouse Brain

Angewandte Chemie, EarlyView.
We present a novel RNA aptamer targeting the transferrin receptor (TfR), conjugated with DSPE lipid, which achieves remarkably efficient brain uptake, reaching brain‐to‐serum ratios as high as 6.5. Through fluorescence imaging and polymerase‐chain reaction analyses, we verify that this new conjugate successfully delivers a substantial amount of DNA ...
Min‐sun Song, Adrian H. Bustos, Lise Bastue, Justas Mikutavicius, Piotr Swiderski, Kelly J. Clemens, Nagy Habib, John Rossi, Kira Astakhova   +8 more
wiley   +2 more sources

Sports Participation Promotes Beneficial Adaptations in the Erythrocyte Guanylate Nucleotide Pool in Male Athletes Aged 20–90 Years

Clinical Interventions in Aging, 2023
Barbara Pospieszna,1 Krzysztof Kusy,1 Ewa Maria Slominska,2 Monika Ciekot-Sołtysiak,1 Jacek Zieliński1 1Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland; 2Department of Biochemistry,
Pospieszna B, Kusy K, Slominska EM, Ciekot-Sołtysiak M, Zieliński J   +4 more
doaj  

Role of Increased Guanosine Triphosphate Cyclohydrolase-1 Expression and Tetrahydrobiopterin Levels upon T Cell Activation

Journal of Biological Chemistry, 2011
Tetrahydrobiopterin (BH4) is an essential co-factor for the nitric-oxide (NO) synthases, and in its absence these enzymes produce superoxide (O2̇̄) rather than NO.
Wei Chen, Li Li, Torben Brod, O. Saeed, Salim R. Thabet, T. Jansen, S. Dikalov, C. Weyand, J. Goronzy, D. Harrison   +9 more
semanticscholar   +1 more source

Lethal Mutagenesis of Poliovirus Mediated by a Mutagenic Pyrimidine Analogue [PDF]

, 2007
Lethal mutagenesis is the mechanism of action of ribavirin against poliovirus (PV) and numerous other RNA viruses. However, there is still considerable debate regarding the mechanism of action of ribavirin against a variety of RNA viruses.
Brown, Daniel M., Cameron, Craig E., Edathil, Jocelyn P., Franco, David, Graci, Jason D., Harki, Daniel A., Korneeva, Victoria S., Loakes, David, Paul, Aniko V., Peterson, Blake R., Smidansky, Eric D., Too, Kathleen   +11 more
core   +4 more sources

The efficacy of PDE5 inhibitors in diabetic patients

Andrology, Volume 11, Issue 2, Page 245-256, February 2023., 2023
Abstract Background Phosphodiesterase 5 inhibitors (PDE5i), since their introduction in the late 1990s, have proven their efficacy in treating several conditions, predominantly pulmonary hypertension and erectile dysfunction where they remain the first‐line therapeutic option.
Agnieszka Swiecicka
wiley   +1 more source

An Information Theoretical Analysis of Kinase Activated Phosphorylation Dephosphorylation Cycle [PDF]

IEEE Transactions on NanoBioscience, Volume 11, Issue 3, pp. 289 - 295 (2012), 2011
Signal transduction, the information processing mechanism in biological cells, is carried out by a network of biochemical reactions. The dynamics of driven biochemical reactions can be studied in terms of nonequilibrium statistical physics. Such systems may also be studied in terms of Shannon's information theory.
arxiv   +1 more source