Results 81 to 90 of about 162,062 (330)

Nitric oxide regulates skeletal muscle fatigue, fiber type, microtubule organization, and mitochondrial ATP synthesis efficiency through cGMP-dependent mechanisms [PDF]

, 2016
Aim: Skeletal muscle nitric oxide–cyclic guanosine monophosphate (NO-cGMP) pathways are impaired in Duchenne and Becker muscular dystrophy partly because of reduced nNOSμ and soluble guanylate cyclase (GC) activity.
Balke, Jordan E, Brouckaert, Peter, Buys, Emmanuel S, Knowels, Gary, Madorma, Derik, Marcinek, David J, Moon, Younghye, Percival, Justin M, Siegel, Michael P   +8 more
core   +1 more source

Expression of activated epidermal growth factor receptors, Ras-guanosine triphosphate, and mitogen-activated protein kinase in human glioblastoma multiforme specimens.

Neurosurgery, 1999
OBJECTIVE Amplification of the epidermal growth factor receptor (EGFR) is a common event in the molecular pathogenesis of high-grade astrocytic tumors, occurring in 50% of glioblastoma multiforme (GBM) cases.
M. Feldkamp, Prateek Lala, N. Lau, Luba Roncari, A. Guha   +4 more
semanticscholar   +1 more source

N‐ to C‐Glycoside Rearrangement of Uridine 5′‐Phosphate in Two Enzymatic Steps for the Production of Pseudouridine 5′‐Phosphate

Biotechnology and Bioengineering, EarlyView.
The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer, Franziska Guld, Bernd Nidetzky   +2 more
wiley   +1 more source

Amylase release from streptolysin O-permeabilized pancreatic acinar cells. Effects of Ca2+, guanosine 5'-[gamma-thio]triphosphate, cyclic AMP, tetanus toxin and botulinum A toxin [PDF]

, 1992
The molecular requirements for amylase release and the intracellular effects of botulinum A toxin and tetanus toxin on amylase release were investigated using rat pancreatic acinar cells permeabilized with streptolysin O.
Ahnert-Hilger, G., Gratzl, Manfred, Kemmer, T. P., Stecher, B., Weller, U.   +4 more
core  

Enhancing antitumor immunity through the combination of cholesterolized TLR7 agonist liposomes and radiotherapy: a role for IL‐1β and the inflammasome pathway

Cancer Communications, EarlyView.
Abstract Background Radiotherapy (RT) is a key treatment modality in cancer therapy, utilizing high‐energy radiation to directly kill tumor cells. Recent research has increasingly highlighted RT's potential to indirectly enhance antitumor immunity. However, this immune activation alone often fails to generate sustained systemic antitumor responses.
Xuejiao Han, Yuan Cheng, Dandan Wan, Aqu Alu, Ziqi Zhang, Zhenfei Bi, Manni Wang, Yan Tang, Weiqi Hong, Siyuan Chen, Li Chen, Yuquan Wei   +11 more
wiley   +1 more source

Guanosine triphosphate cyclohydrolase I deficiency: a rare cause of hyperphenylalaninemia

The Turkish Journal of Pediatrics, 1999
Tetrahydrobiopterin (BH4) deficiencies are a heterogeneous group of disorders caused by a defect in two of the three enzymes involved in its biosynthesis or in the two recycling enzymes.
T Coşkun, T Karagöz, S Kalkanoğlu, A Tokatli, I Ozalp, B Thöny, N Blau   +6 more
doaj  

Protocol for structural and biochemical analyses of RhoA GTPase

STAR Protocols, 2021
Summary: Ras GTPases in complex with Guanosine triphosphate (GTP) or GTP analog exhibit dynamic equilibrium between two interconvertible conformations—an inactive state 1 and an active state 2.
Yuan Lin, Miki Watanabe-Chailland, Yi Zheng   +2 more
doaj  

Some taste substances are direct activators of G-proteins [PDF]

, 1994
Amphiphilic substances may stimulate cellular events through direct activation of G-proteins. The present experiments indicate that several amphiphilic sweeteners and the bitter tastant, quinine, activate transducin and Gi/Go-proteins.
Grünbaum, L., Naim, M., Nürnberg, B., Schultz, Günter, Seifert, Roland   +4 more
core   +3 more sources

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

A novel hemizygous mutation associated with severe intellectual disability and epilepsy: a case report

Journal of International Medical Research, 2021
ARHGEF9 encodes collybistin, a brain-specific guanosine diphosphate-guanosine-5′-triphosphate exchange factor that plays an important role in clustering of gephyrin and γ-aminobutyric acid type A receptors in the postsynaptic membrane.
Tong Qiu, Qian Dai, Qiu Wang
doaj   +1 more source