Results 81 to 90 of about 177,246 (350)

The Utilization of Purines and Their Ribosyl Derivatives for the Formation of Adenosine Triphosphate and Guanosine Triphosphate in the Rabbit Reticulocyte [PDF]

Journal of Biological Chemistry, 1966
Abstract The rabbit reticulocyte is capable of utilizing purines and their ribosyl derivatives for nucleoside triphosphate formation. Adenine, adenosine, hypoxanthine, and inosine are used extensively for the synthesis of adenosine triphosphate. Xanthine, guanine, and guanosine are utilized primarily for the synthesis of guanosine triphosphate.
Jean L. Cook, Madeleine Vibert
openaire   +2 more sources

Nanoparticle‐Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy

Advanced Science, EarlyView.
This study presents a nanoparticle‐embedded nanofiber (5F/STFM/R‐ES) to inhibit melanoma growth and reduce the risk of metastasis and recurrence. The drug delivery system induces ferroptosis and potentiates immunotherapy through resiquimod (R848) and Fe/Mn‐based metal‐polyphenol networks (TFM).
Mingyang Li, Rongrong Li, Baotong Xu, Yuhan Lian, Chenyu Yang, Jingwen Li, Junhao Liang, Linhan Ding, Dongsheng Zhang, Jing Guo, Xiao Fu   +10 more
wiley   +1 more source

Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase [PDF]

, 2007
This research was supported by the German Academic Exchange Service (DAAD), the Wellcome Trust (TKS and WNH as Trust Senior Research fellows), the Biotechnology and Biological Science Research Council (Structural Proteomics of Rational Targets) and the ...
Hunter, William N., Sgraja, Tanja, Smith, Terry K   +2 more
core   +2 more sources

Guanosine triphosphate cyclohydrolase I deficiency: a rare cause of hyperphenylalaninemia

The Turkish Journal of Pediatrics, 1999
Tetrahydrobiopterin (BH4) deficiencies are a heterogeneous group of disorders caused by a defect in two of the three enzymes involved in its biosynthesis or in the two recycling enzymes.
T Coşkun, T Karagöz, S Kalkanoğlu, A Tokatli, I Ozalp, B Thöny, N Blau   +6 more
doaj  

Structural Insights into the Regulation Mechanism of Small GTPases by GEFs

Molecules, 2019
Small GTPases are key regulators of cellular events, and their dysfunction causes many types of cancer. They serve as molecular switches by cycling between inactive guanosine diphosphate (GDP)-bound and active guanosine triphosphate (GTP)-bound states ...
Sachiko Toma-Fukai, Toshiyuki Shimizu
doaj   +1 more source

Sonoepigenetic Modification Mechanoprimes Early Osteogenic Commitment in Mesenchymal Stem Cells

Advanced Science, EarlyView.
Brief 10 min bursts of high frequency (10 MHz) vibrational mechanostimulation to stem cells are shown to activate their epigenetic machinery to condition their differentiation down an osteogenic lineage within just 3 days, which is much earlier than that with other forms of mechanostimuli, and without requiring any biochemical additives. Abstract Cells
Lizebona A. Ambattu, Blanca del Rosal, Carmelo Ferrai, Leslie Y. Yeo   +3 more
wiley   +1 more source

Liquid chromatographic method for extracellular Guanosine 5′-triphosphate and tetrahydrobiopterin pathway products analysis from cadaveric samples and human biofluids

Journal of Chromatography Open
To gain a deep insight and to obtain a superior understanding about guanosine-based pathway, this paper reports an innovative approach to study this critical subject.
M. Perrucci, C. Santangelo, D. Bondi, T. Pietrangelo, F. Savini, A.M. Catena, M. Bonelli, M. Locatelli, C. D'Ovidio   +8 more
doaj   +1 more source

Visual and Plasmon Resonance Absorption Sensor for Adenosine Triphosphate Based on the High Affinity between Phosphate and Zr(IV)

Sensors, 2016
Zr(IV) can form phosphate and Zr(IV) (–PO32−–Zr4+–) complex owing to the high affinity between Zr(IV) with phosphate. Zr(IV) can induce the aggregation of gold nanoparticles (AuNPs), while adenosine triphosphate(ATP) can prevent Zr(IV)-induced ...
Wenjing Qi, Zhongyuan Liu, Wei Zhang, Mohamed Ibrahim Halawa, Guobao Xu   +4 more
doaj   +1 more source

Metabolic Engineering of Bacillus subtilis for Riboflavin Production: A Review

Microorganisms, 2023
Riboflavin (vitamin B2) is one of the essential vitamins that the human body needs to maintain normal metabolism. Its biosynthesis has become one of the successful models for gradual replacement of traditional chemical production routes. B.
Yang Liu, Quan Zhang, Xiaoxiao Qi, Huipeng Gao, Meng Wang, Hao Guan, Bo Yu   +6 more
doaj   +1 more source

Lactylation in cancer biology: Unlocking new avenues for research and therapy

Cancer Communications, EarlyView.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou, Zhenya Hong, Huimin Zeng, Changyi Zhang, Peng Zhang, Ding Ma, Zhiqiang Han   +6 more
wiley   +1 more source