Results 111 to 120 of about 40,447 (213)

Distinct Roles of SLC26A3 and CFTR in Surface pH Regulation and Bicarbonate Secretion in Human Intestinal Epithelium

Acta Physiologica, Volume 242, Issue 2, February 2026.
ABSTRACT Background and Aims Colonic bicarbonate secretion is mediated by the chloride/bicarbonate exchanger SLC26A3 and the cystic fibrosis transmembrane conductance regulator (CFTR). Dysfunction of either causes luminal acidosis, altered mucus properties, and inflammation.
Mahdi Amiri, Azam Salari, Ursula Seidler
wiley   +1 more source

Increased adhesive properties of neutrophils in sickle cell disease may be reversed by pharmacological nitric oxide donation

Haematologica, 2008
Increased leukocyte adhesion to vascular endothelium contributes to vaso-occlusion in sickle cell disease. Since nitric oxide bioavailability is decreased in sickle cell disease and nitric oxide may inhibit leukocyte adhesion, we investigated whether ...
Andreia A. Canalli, Carla F. Franco-Penteado, Sara T.O. Saad, Nicola Conran, Fernando F. Costa   +4 more
doaj   +1 more source

Reactive oxygen-related diseases: therapeutic targets and emerging clinical indications [PDF]

, 2015
SIGNIFICANCE Enhanced levels of reactive oxygen species (ROS) have been associated with different disease states. Most attempts to validate and exploit these associations by chronic antioxidant therapies have provided disappointing results. Hence, the
Ana I. Casas, Andreas Daiber, Antonio Cuadrado, Brunner HG, Fabio Di Lisa, Ghassan J. Maghzal, Hampton MB, Harald H.H.W. Schmidt, Hou YC, Karl H. Krause, Klebanoff SJ., Liu VW, Manuela G. López, Nina Kaludercic, Pietro Ghezzi, Roland Stocker, Sandler M, Savenkova ML, Sonia Leach, Tamara Seredenina, V. Thao-Vi Dao, Vincent Jaquet   +21 more
core   +3 more sources

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model [PDF]

, 2013
© 2013 Peake et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and ...
Achan, P, Bader, DL, Chowdhury, TT, Hobbs, AJ, Moyes, AJ, Peake, N, Ramachandran, M, Salter, DM, Su, N   +8 more
core   +3 more sources

Vericiguat – possibly next weapon to overcome heart failure. Review of latest literature

Journal of Education, Health and Sport
Introduction Heart failure (HF) is a common clinical syndrome characterized by symptoms such as breathlessness and fatigue, affecting 1-2% of adults in developed countries.
Mikolaj Biskupski, Aleksandra Cygnarowicz, Aneta Klaudia Wojtas, Krystyna Zabojska, Urszula Korotko, Aneta Mandziuk, Kinga Witowska, Mariola Turemka, Negar Hosseinnejad, Karolina Sacher   +9 more
doaj   +1 more source

Management of Pulmonary Arterial Hypertension: Current Strategies and Future Prospects

Life
Primary pulmonary hypertension (PPH), now known as pulmonary arterial hypertension (PAH), has induced significant treatment breakthroughs in the past decade.
Munish Sharma, Vivek Paudyal, Saifullah Khalid Syed, Rubi Thapa, Nadeem Kassam, Salim Surani   +5 more
doaj   +1 more source

Effect of oxygen on relaxation of retinal pericytes by sodium nitroprusside [PDF]

, 2018
• Background: This study addresses whether oxygen modulates the relaxation induced in retinal pericytes by sodium nitroprusside (SNP), a nitric oxide (NO) donor that stimulates the NO/guanylate cyclase pathway.
Anderson, Douglas, Chen, Qian, Haefliger, Ivan   +2 more
core  

Guanylate Cyclase, a Cell Surface Receptor

Journal of Biological Chemistry, 1989
Guanylate cyclase appears to represent a central member of a diverse family of proteins involved in cell signaling mechanisms including the protein kinases, a low Mr ANP receptor, and possibly adenylate cyclase (based on limited sequence identity with the yeast enzyme).
openaire   +2 more sources

The Role of Vericiguat in Early Phases of Anterior Myocardial Infarction: A Potential Game-Changer?

Medicina
Anterior myocardial infarction is a critical condition with significant implications for cardiac function and patient prognosis. Despite advancements in reperfusion therapies, optimizing recovery during the early phases of myocardial infarction remains ...
Federico Cacciapuoti, Ciro Mauro, Valentina Capone, Salvatore Chianese, Luca Gaetano Tarquinio, Rossella Gottilla, Fabio Marsico, Salvatore Crispo, Fulvio Cacciapuoti   +8 more
doaj   +1 more source

Proteomics and phosphoproteomics reveal novel proteins involved in Cipangopaludina chinensis carcasses

Frontiers in Chemistry
Cipangopaludina chinensis is a common freshwater mollusk that is widely distributed worldwide, especially in China. In our research, 1,382 proteins and 1,039 phosphorylated proteins were identified from C.
Gongzhen Liu, Kangyu Zhong, Shanmin Gong, Xinru Li, Yanshen Li   +4 more
doaj   +1 more source