Results 121 to 130 of about 39,412 (236)

Beyond red/far‐red sensing: phytochrome perception of the marine light field by microalgae

New Phytologist, Volume 250, Issue 5, Page 2837-2844, June 2026.
Summary Phytochromes (PHYs) are a major group of photoreceptors, described as red and far‐red light sensors in land plants. Recent genomic and metagenomic explorations have revealed the presence of PHYs also in various eukaryotic microalgae originating from distinct endosymbiotic events.
Carole Duchêne, Marianne Jaubert, Angela Falciatore   +2 more
wiley   +1 more source

Temporal Dissociation of Impaired Glucose Tolerance, Adipose Lipid Remodeling and Endothelial Dysfunction in Aorta After HFD Withdrawal

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
HFD withdrawal results in early restoration of systemic glucose tolerance and PVAT lipid unsaturation that is temporarily dissociated from the reversal of endothelial dysfunction in aorta that may be linked to altered PVAT function featured by impaired guanylate cyclase signaling pathway.
Krzysztof Czamara, Izabela Czyzynska‐Cichon, Anna Bar, Ewa Stanek, Mateusz Wawro, Marta Z. Pacia, Zeinep Berkimbayeva, Brygida Marczyk, Elvira Bragado‐García, Paloma Palma‐Guzman, Maria S. Fernandez‐Alfonso, Stefan Chlopicki   +11 more
wiley   +1 more source

Reactive oxygen-related diseases: therapeutic targets and emerging clinical indications [PDF]

, 2015
SIGNIFICANCE Enhanced levels of reactive oxygen species (ROS) have been associated with different disease states. Most attempts to validate and exploit these associations by chronic antioxidant therapies have provided disappointing results. Hence, the
Ana I. Casas, Andreas Daiber, Antonio Cuadrado, Brunner HG, Fabio Di Lisa, Ghassan J. Maghzal, Hampton MB, Harald H.H.W. Schmidt, Hou YC, Karl H. Krause, Klebanoff SJ., Liu VW, Manuela G. López, Nina Kaludercic, Pietro Ghezzi, Roland Stocker, Sandler M, Savenkova ML, Sonia Leach, Tamara Seredenina, V. Thao-Vi Dao, Vincent Jaquet   +21 more
core   +3 more sources

Guanylate cyclase and the ⋅NO/cGMP signaling pathway

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1999
Signal transduction with the diatomic radical nitric oxide (NO) is involved in a number of important physiological processes, including smooth muscle relaxation and neurotransmission. Soluble guanylate cyclase (sGC), a heterodimeric enzyme that converts guanosine triphosphate to cyclic guanosine monophosphate, is a critical component of this signaling ...
Denninger, John W, Marletta, Michael A
openaire   +2 more sources

Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A

Phytotherapy Research, Volume 40, Issue 5, Page 2710-2729, May 2026.
ABSTRACT Background and Aim New therapeutic strategies for heart failure are urgently needed. The protective effects of cyclic guanosine monophosphate (cGMP)—protein kinase G (PKG) pathway on heart have been widely reported. Despite phosphodiesterase 9A (PDE9A) inhibitors combating cardiac remodeling, clinically available drugs are lacking. Hederagenin
Liqian Chen, Xinghong Zhou, Yanting You, Jieyu Chen, Baizhao Peng, Yijian Deng, Shuai Ji, Ying Yang, Xiaohu Chen, Huaxi Liu, Shuxuan Yang, Hiu Yee Kwan, Wen Jin, Lei Zhang, Yuegang Wang, Xiaoshan Zhao, Yanyan Liu   +16 more
wiley   +1 more source

Functional EF-hands in neuronal calcium sensor GCAP2 determine its phosphorylation state and subcellular distribution in vivo, and are essential for photoreceptor cell integrity [PDF]

, 2014
The neuronal calcium sensor proteins GCAPs (guanylate cyclase activating proteins) switch between Ca2+-free and Ca2+-bound conformational states and confer calcium sensitivity to guanylate cyclase at retinal photoreceptor cells.
Chen, Jeannie, Hoyo, N.L., López Begines, Santiago, Méndez Zunzunegui, Ana, Rosa López, José Luis   +4 more
core   +4 more sources

TNF‐α partially modulates the endothelial dysfunction during the acute phase of Trypanosoma cruzi infection

British Journal of Pharmacology, Volume 183, Issue 10, Page 2256-2272, May 2026.
Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado, Wanessa M. C. Awata, Gustavo F. Pimenta, Barbara M. Marchetti, Maiara V. Providello, Sérgio De Albuquerque, Carlos R. Tirapelli   +6 more
wiley   +1 more source

Visual consequences of molecular changes in the guanylate cyclase activating protein [PDF]

, 2014
Purpose: In this study, we characterize and model changes in visual performance associated with a Tyr99Cys substitution in the guanylate cyclase activating protein (GCAP1) in four family members aged between 39 and 55 years.
Henning, B, Michaelides, M, Moore, AT, Ripamonti, C, Stockman, A, Webster, AR   +5 more
core   +1 more source

Maternal exercise improves vascular function in hypertensive offspring via A‐kinase anchoring protein 150 gene (Akap5) epigenetic modifications

British Journal of Pharmacology, Volume 183, Issue 10, Page 2592-2612, May 2026.
Background and Purpose Regular physical activity is an effective non‐pharmacological approach to hypertension management and maternal exercise improves offspring cardiovascular health, although mechanisms remain unclear. A‐kinase anchoring protein 150 (AKAP150) targets protein kinase Cα to L‐type Ca2+ channels (CaV1.2), enhancing vascular tone in ...
Fang Qiu, Yanyan Zhang, Meiling Shan, Jiaqi Cao, Zihan Fan, Zhaoxia Xu, Xiaozhen Ding, Xiaodong Liu, Lijun Shi   +8 more
wiley   +1 more source

Relaxation of rabbit corpus cavernosum smooth muscle and aortic vascular endothelium induced by new nitric oxide donor substances of the nitrosyl-ruthenium complex

International Brazilian Journal of Urology, 2008
INTRODUCTION: Endothelial dysfunction characterized by endogenous nitric oxide (NO) deficiency made 56% of patients affected with erectile dysfunction decline treatment with PDE-5 inhibitors.
Joao B. G. Cerqueira, Lucio F. G. Silva, Luis G. F. Lopes, Maria E. A. Moraes, Nilberto R. F. Nascimento   +4 more
doaj   +1 more source