Results 1 to 10 of about 3,853 (75)

Guanylate cyclase 2C agonism corrects CFTR mutants. [PDF]

JCI Insight, 2017
Cystic fibrosis (CF) is a genetic disorder in which epithelium-generated fluid flow from the lung, intestine, and pancreas is impaired due to mutations disrupting CF transmembrane conductance regulator (CFTR) channel function. CF manifestations of the pancreas and lung are present in the vast majority of CF patients, and 15% of CF infants are born with
Arora K, Huang Y, Mun K, Yarlagadda S, Sundaram N, Kessler MM, Hannig G, Kurtz CB, Silos-Santiago I, Helmrath M, Palermo JJ, Clancy JP, Steinbrecher KA, Naren AP.   +13 more
europepmc   +5 more sources

Catalytic region mimetics in Na+/H+ exchanger regulatory factor 4 suppress guanylate cyclase 2C activity to regulate enterotoxin triggered diarrhea. [PDF]

J Biol Chem
Abstract Guanylate cyclase 2C (GCC), a receptor for bacterial heat-stable enterotoxin ST on the apical intestinal epithelium, generates cGMP and causes excessive intestinal secretion leading to diarrhea upon activation. This study reports that the C-terminal PSD95, Dlg1, ZO-1 (PDZ) domain interacting motif in GCC interacts with scaffolding ...
Ramananda Y, Liyanage P, Huang Y, Porollo A, Hannig G, Naren AP, Arora K.   +6 more
europepmc   +6 more sources

Meconium ileus caused by mutations in GUCY2C, encoding the CFTR-activating guanylate cyclase 2C. [PDF]

Am J Hum Genet, 2012
Meconium ileus, intestinal obstruction in the newborn, is caused in most cases by CFTR mutations modulated by yet-unidentified modifier genes. We now show that in two unrelated consanguineous Bedouin kindreds, an autosomal-recessive phenotype of meconium ileus that is not associated with cystic fibrosis (CF) is caused by different homozygous mutations ...
Romi H, Cohen I, Landau D, Alkrinawi S, Yerushalmi B, Hershkovitz R, Newman-Heiman N, Cutting GR, Ofir R, Sivan S, Birk OS.   +10 more
europepmc   +5 more sources

GUCY2C (guanylate cyclase 2C (heat stable enterotoxin receptor)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2012
Review on GUCY2C (guanylate cyclase 2C (heat stable enterotoxin receptor)), with data on DNA, on the protein encoded, and where the gene is implicated.
Schulz, S, Waldman, SA
openaire   +4 more sources

GUCY2C (guanylate cyclase 2C (heat stable enterotoxin receptor)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2014
Review on GUCY2C (guanylate cyclase 2C (heat stable enterotoxin receptor)), with data on DNA, on the protein encoded, and where the gene is implicated.
Blomain, ES, Waldman, SA
openaire   +4 more sources

Intestinal obstruction in the newborn due to guanylate cyclase 2C deficiency [PDF]

, 2020
INSERM
openaire   +2 more sources

Chronic infantile diarrhea due to guanylate cyclase 2C overactivity [PDF]

, 2020
INSERM
openaire   +2 more sources

Effect of guanylin peptides on pancreas steatosis and function in experimental diet-induced obesity and after bariatric surgery

Frontiers in Endocrinology, 2023
IntroductionObesity contributes to ectopic fat deposition in non-adipose organs, including the pancreas. Pancreas steatosis associates with inflammation and β-cell dysfunction, contributing to the onset of insulin resistance and type 2 diabetes.
Aarón Otero, Sara Becerril, Sara Becerril, Sara Becerril, Marina Martín, Javier A. Cienfuegos, Javier A. Cienfuegos, Javier A. Cienfuegos, Víctor Valentí, Víctor Valentí, Víctor Valentí, Rafael Moncada, Rafael Moncada, Rafael Moncada, Victoria Catalán, Victoria Catalán, Victoria Catalán, Javier Gómez-Ambrosi, Javier Gómez-Ambrosi, Javier Gómez-Ambrosi, María A. Burrell, María A. Burrell, María A. Burrell, Gema Frühbeck, Gema Frühbeck, Gema Frühbeck, Gema Frühbeck, Amaia Rodríguez, Amaia Rodríguez, Amaia Rodríguez   +29 more
doaj   +1 more source

Functional Analysis of Novel Candidate Regulators of Insulin Secretion in the MIN6 Mouse Pancreatic β Cell Line. [PDF]

PLoS ONE, 2016
Elucidating the regulation of glucose-stimulated insulin secretion (GSIS) in pancreatic β cells is important for understanding and treating diabetes. The pancreatic β cell line, MIN6, retains GSIS but gradually loses it in long-term culture.
Masaki Kobayashi, Eiji Yamato, Koji Tanabe, Fumi Tashiro, Satsuki Miyazaki, Jun-ichi Miyazaki   +5 more
doaj   +1 more source

Decreased Colonic Guanylin/Uroguanylin Expression and Dried Stool Property in Mice With Social Defeat Stress

Frontiers in Physiology, 2020
Psychological stress is deeply involved in the pathophysiology of not only mental illness but also functional gastrointestinal disorders. In the present study, we examined the relationship between psychological stress and abnormality of stool properties,
Nobuhiko Ebisutani, Hirokazu Fukui, Heihachiro Nishimura, Takashi Nakanishi, Kenki Morimoto, Shiho Itou, Ayumi Nakamura, Mizuki Masutani, Mika Hori, Toshihiko Tomita, Tadayuki Oshima, Emiko Kasahara, Atsuo Sekiyama, Hiroto Miwa   +13 more
doaj   +1 more source