Results 11 to 20 of about 3,853 (75)
The Effectiveness of Plecanatide for Treating Constipation and Bloating in Patients Aged 18 to 40 Years With Irritable Bowel Syndrome: Utilization of a New Composite Trisymptom Endpoint. [PDF]
J Gastroenterol HepatolABSTRACT Background and Aim Irritable bowel syndrome with constipation (IBS‐C) is characterized by multiple sensory symptoms, including abdominal pain, bloating, and bowel habit alterations. Therapeutic response should address all components. This study assesses a new exploratory trisymptom composite efficacy endpoint in an IBS‐C population of young ...
Brenner DM +4 more
europepmc +2 more sources
Endothelium-Independent Relaxation of Alkaloid Boldine in Isolated Aortas From Normotensive and Hypertensive Rats: Participation of Ca<sup>2+</sup> Channels. [PDF]
Chem BiodiversInvolvement of Ca2+ channels in boldine‐induced vascular relaxation. ABSTRACT The regulation of vascular tone plays a fundamental role in blood pressure homeostasis and still represents a significant challenge in clinical practice. Boldine, a naturally occurring alkaloid from Peumus boldus, has emerged as a compound of interest due to its therapeutic ...
Cavichiolo MO +3 more
europepmc +2 more sources
A signal transduction blind spot: the function of adenylyl cyclase transmembrane domains. [PDF]
FEBS JTransmembrane adenylyl cyclases (tmACs) are essential for synthesising the universal second messenger cyclic AMP. All tmACs share a common topology that includes a large 12‐helix transmembrane (TM) domain. This domain accounts for ~ 35% of the coding sequence but its function is still an open question.
Dowsell RS, Gold MG.
europepmc +2 more sources
Comparative Analysis of Convergent Jellyfish Eyes Reveals Extensive Differences in Expression of Vision-Related Genes. [PDF]
Ecol EvolEyes have evolved in many different lineages, including several times within jellyfish, yet the relative contributions of shared and lineage‐specific genes to convergent eyes are not known. We find that three long‐diverged species of jellyfish have mostly divergent patterns of gene expression in their eye‐bearing tissues, suggesting a major role for ...
Picciani N +8 more
europepmc +2 more sources
Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead. [PDF]
Adv Genet (Hoboken)Optogenetics provides up to millisecond scale, cell type‐specific control of biology using light‐sensitive proteins. This review chronicles two decades of tool development, from microbial rhodopsins and photoactivated enzymes to allosteric switches, surveys broad applications in neuroscience, molecular and cell biology, cardiology, immunology, and ...
Duan X, Zhu M, Gao S.
europepmc +2 more sources
Journal of Pediatric Gastroenterology and Nutrition, EarlyView.Abstract Objectives Pediatric intestinal pseudo‐obstruction (PIPO) is a severe bowel motility disorder characterized by impaired propulsion of gastrointestinal contents without mechanical obstruction. PIPO encompasses congenital and acquired disorders, including neuropathies, myopathies, and mesenchymopathies.
Sharon Wolfson +8 more
wiley +1 more source
A supramolecular assembly of cone‐specific G‐protein and cryptochrome 4a on lipid bilayer
The FEBS Journal, EarlyView.Immobilized phospholipid bilayers on a sensor chip surface serve as membrane platform to investigate critical protein–lipid and protein–protein interaction processes by surface plasmon resonance. The putative magnetoreceptor cryptochrome 4a and the myristoylated cone‐specific G‐protein α‐subunit (Gtα) bind with high affinity to immobilized lipid ...
Ümmügülsüm Güzelsoy‐Flügge +3 more
wiley +1 more source
Food Frontiers, Volume 7, Issue 1, January 2026.ABSTRACT Intestinal health could be affected by intestinal motility, which is controlled by the enteric nervous system. In this study, we found that α‐ketoglutarate (AKG) inhibits intestinal motility and improves intestinal permeability, accompanied by an increased count of intestinal flora.
Guli Xu +9 more
wiley +1 more source
MedComm, Volume 6, Issue 12, December 2025.Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Gege Li +13 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S259-S306, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source