Results 71 to 75 of about 3,853 (75)

Pulmonary haemodynamics and right heart function during exercise at high versus low altitude in patients with pulmonary vascular disease: a randomised crossover trial. [PDF]

Heart
Müller J, Mayer L, Schneider SR, Bauer M, Furian M, Bloch KE, Schwarz EI, Lichtblau M, Silvia U.   +8 more
europepmc   +1 more source

The mayfly Neocloeon triangulifer senses decreasing oxygen availability (PO2) and responds by reducing ion uptake and altering gene expression.

J Exp Biol
Cochran JK, Buchwalter DB.
europepmc   +1 more source

Oral Pharmacological Activation of Hypothalamic Guanylate Cyclase 2C Receptor Stimulates Brown Fat Thermogenesis to Reduce Body Weight

Neuroendocrinology, 2020
Linaclotide is a synthetic peptide approved by the FDA for the treatment of constipation-predominant irritable bowel syndrome and chronic constipation. Linaclotide binds and activates the transmembrane receptor guanylate cyclase 2C (<i>Gucy2c</i>).
Cintia, Folgueira, Francisco Leonardo, Torres-Leal, Daniel, Beiroa, Verónica, Pena-León, Natália, Da Silva Lima, Edward, Milbank, Ana, Senra, Omar, Al-Massadi, Miguel, López, Carlos, Diéguez, Luisa M, Seoane, Rubén, Nogueiras   +11 more
openaire   +3 more sources

Guanylate cyclase 2C ( GUCY2C ; GUC )expression and the tumor immune microenvironment (TIME) in gastrointestinal (GI) cancers.

Journal of Clinical Oncology
3538 Background: An immunosuppressive TIME can result in reduced efficacy of immune checkpoint inhibitors (ICIs) in GI tumors. GUC is preferentially expressed in colorectal (CRC), gastroesophageal junction (GEJ) and gastric adenocarcinoma (GA).
Paul Sackstein, Harris Benjamin Krause, Andrew Elliott, Heinz-Josef Lenz, Francesca Battaglin, Ajay Prakash, Emil Lou, Matthew James Oberley, Andreas Seeber, Richard M. Goldberg, Axel Grothey, Anthony F. Shields, John Marshall, Sanjay Goel, Benjamin Adam Weinberg   +14 more
openaire   +2 more sources

1017 - Guanylate Cyclase 2C Activation Rescues the Folding Defect in F508Del CFTR

Gastroenterology, 2018
Kavisha Arora, Marco Kessler, Gerhard Hannig, Anjaparavanda P. Naren   +3 more
openaire   +2 more sources