Results 101 to 110 of about 784,908 (283)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
, 2011 This thesis is a play following Adele, a woman in her forties, as she investigates her mother’s involvement in the Korean War, more than fifty years after it. Following her mother’s death, she learns details of her military service, and of the existence of her former lover, who spent part of the war in the care of a Korean family in Seoul, struggling ...
openaire +3 more sources
Silent Guardian: The 15th New Jersey Monument
, 2015 This post is part of a series featuring behind-the-scenes dispatches from our Pohanka interns working on the front lines of history this summer as interpreters, archivists, and preservationists. See here for the introduction to the series.
Smith, Elizabeth A.
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Active Shooter Events: The Guardian Plan [PDF]
, 2018 The decision on how to protect the children and youth while at schools is a serious conversation with varying agreements on the best practices. Some feel that school personnel should not be trained nor expected to be able to react to an armed person ...
Sampson, Pauline M., Walker, David R.
core +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
İstanbul Hukuk MecmuasıThe provision of Article 407/1 of the Turkish Civil Code, which mandates that every adult who has been sentenced to a term of imprisonment of one year or longer, along with the related provisions of Articles 407/2 and 471 of the same Code, have been ...
Caner Taşatan
doaj +1 more source