Results 81 to 90 of about 1,893,825 (286)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Przeglad Socjologii JakosciowejTraining and working with a guide dog both take place largely on the move, in public spaces, on the way to the next destination. Trainers, puppy raisers, and visually impaired handlers travel many miles with the dog, learning about each other and ...
Kamil Pietrowiak
doaj +1 more source
Embodied Cognition and Representation in Domesticated Dogs [PDF]
, 2015 Embodied cognition is a relatively recent approach in the philosophy of mind. Similarly, the volume of research into dog cognition has increased in the last decade and is set to keep on growing as we learn more about the animals with which we have ...
Osto, Kate
core
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
A colony of dog guides: analysis of the genetic variability assessed by pedigree data
Italian Journal of Animal Science, 2010 The study presents the analysis of the genetic variability in a colony of dog guides. Three breeds, Labrador (L), Golden Retriever (GR), and German Shepherd (GS), were evaluated.
Roberta Ciampolini +3 more
doaj +1 more source
The Preparation and the Use of Guide and Assistance Dogs
, 2021 The thesis deals with the preparation and the use of guide and assitence dogs. The first part characterises basic terms based on therapy with animals, three types of auxiliary dogs, the history and the right choice of these dogs, their training, final ...
REŠLOVÁ, Dominika
core
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
Prevalence of Leishmania spp. infection in domestic dogs in Chapare, Bolivia.
, 2011 Data on Leishmania spp. infection in dogs in Bolivia is scarce. Dogs from an area where 90% of human cutaneous leishmaniasis (CL) cases are due to Leishmania (Viannia) braziliensis were screened for Leishmania infection using established enzyme-linked ...
Reithinger, Richard +11 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source