Results 211 to 220 of about 4,450,920 (398)

Orthogonal and multiplexable genetic perturbations with an engineered prime editor and a diverse RNA array

Nature Communications
Programmable and modular systems capable of orthogonal genomic and transcriptomic perturbations are crucial for biological research and treating human genetic diseases.
Qichen Yuan, Hongzhi Zeng, Tyler C. Daniel, Qingzhuo Liu, Yongjie Yang, Emmanuel C. Osikpa, Qiaochu Yang, Advaith Peddi, Liliana M. Abramson, Boyang Zhang, Yong Xu, Xue Gao   +11 more
doaj   +1 more source

Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes [PDF]

, 2023
Peter H. Yoon, Petr Skopintsev, Honglue Shi, Lin-Xing Chen, Benjamin A. Adler, Muntathar Al-Shimary, Rory J. Craig, Kenneth J. Loi, Evan C. DeTurk, Zheng Li, Jasmine Amerasekera, Marena Trinidad, Hunter Nisonoff, Kai Chen, Arushi Lahiri, Ron Boger, Steve Jacobsen, Jillian F. Banfield, Jennifer A. Doudna   +18 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A comprehensive RNA handling and transcriptomics guide for high-throughput processing of Plasmodium blood-stage samples

, 2020
Michal Kucharski, Jaishree Tripathi, Sourav Nayak, Lei Zhu, Grennady Wirjanata, Rob W. van der Pluijm, Mehul Dhorda, Arjen M. Dondorp, Zbynek Bozdech   +8 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Guide RNA Library Titration of Cas9 Cell Lines v1

, 2020
Verity Goodwin, Emily Souster, Charlotte Beaver, Adam Jackson, Rizwan Ansari, Mathew J. Garnett, Fiona M. Behan   +6 more
openalex   +1 more source

Cis-acting Elements Stimulating Kinetoplastid Guide RNA-directed Editing [PDF]

, 2003
Lisa M. Oppegard, Matthew L. Hillestad, Ryan T. McCarthy, R.D. Pai, Gregory J. Connell   +4 more
openalex   +1 more source

Integrative machine learning algorithms for developing a consensus RNA modification-based signature for guiding clinical decision-making in bladder cancer [PDF]

, 2023
Shijun Jia, Linhan Zhai, Feng Wu, Wenzhi Lv, Xiangde Min, Shuang Zhang, Feng Li   +6 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source