Results 261 to 270 of about 570,529 (349)

Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA [PDF]

, 2014
Suresh Ramakrishna, Abu-Bonsrah Kwaku Dad, Jagadish Beloor, Ramu Gopalappa, Sang‐Kyung Lee, Seokjoong Kim   +5 more
openalex   +1 more source

Interplay of integrins and selectins in metastasis

Molecular Oncology, EarlyView.
Here we review the role of integrins and their interplay with selectins in metastasis. The efficacy of integrin‐targeted therapies may be reduced in tumors where metastasis relies heavily on selectins. In certain tumors, integrins and selectins exhibit a synergistic interaction during intraperitoneal dissemination.
Diana Maltseva, Ashot Nersisyan, Alexander Tonevitsky   +2 more
wiley   +1 more source

Deep learning enhancing guide RNA design for CRISPR/Cas12a-based diagnostics. [PDF]

Imeta
Huang B, Guo L, Yin H, Wu Y, Zeng Z, Xu S, Lou Y, Ai Z, Zhang W, Kan X, Yu Q, Du S, Li C, Wu L, Huang X, Wang S, Wang X.   +16 more
europepmc   +1 more source

Organization of minicircle cassettes and guide RNA genes in Trypanosoma brucei. [PDF]

RNA, 2022
Cooper S, Wadsworth ES, Schnaufer A, Savill NJ.   +3 more
europepmc   +1 more source

Magnetic Nanostructures for Biomedical Applications: An Iron Nitride Crystal/Cationic Lipid Nanocomposite for Enhanced Magnetically Guided RNA Interference in Cancer Cells

, 2011
Yoshihisa Namiki, Satoshi Matsunuma, Tetsutaro Inoue, Shigeo Koido, Akihito Tsubota, Yoji Kuse, Norio Tsubokawa   +6 more
openalex   +1 more source

Cut Site Selection by the Two Nuclease Domains of the Cas9 RNA-guided Endonuclease [PDF]

, 2014
Hongfan Chen, Ji-Hoon Choi, Scott Bailey
openalex   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

CRISPR-Cas9-based one-step multiplexed genome editing through optimizing guide RNA processing strategies in Pichia pastoris. [PDF]

Synth Syst Biotechnol
Chen K, Maimaitirexiati G, Zhang Q, Li Y, Liu X, Tang H, Gao X, Wang B, Yu T, Guo S.   +9 more
europepmc   +1 more source

Self-Supplying Guide RNA-Mediated CRISPR/Cas12a Fluorescence System for Sensitive Detection of T4 PNKP. [PDF]

Molecules, 2022
Yuan X, Yuan H, Liu B, Liu Y.
europepmc   +1 more source

Microglial reprogramming: a potential new frontier in enhancing immunotherapy for melanoma brain metastasis

Molecular Oncology, EarlyView.
Microglia act as tumor suppressors during brain metastasis colonization but shift to a tumor‐promoting role after melanoma brain metastases form. NF‐κB/RelA signaling emerges as a key driver of this phenotypic shift. Targeting this pathway reprograms microglia into a pro‐inflammatory state, enhancing antitumor immunity and immune checkpoint inhibitor ...
Noam Savion‐Gaiger, Dorin Bar‐Ziv, Harriet Kluger   +2 more
wiley   +1 more source