Results 261 to 270 of about 4,450,920 (398)

RNA-guided Nucleotide Modification of Ribosomal and Other RNAs [PDF]

Journal of Biological Chemistry, 2003
Wayne A, Decatur, Maurille J, Fournier
openaire   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Mutant allele formation and inheritance during Cas9/guide RNA-mediated gene drive in a population modification mosquito strain for human malaria control. [PDF]

Genetics
Carballar-Lejarazú R, Pham TB, Tushar T, James AA.   +3 more
europepmc   +1 more source

Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9 [PDF]

, 2016
Digvijay Singh, Samuel H. Sternberg, Jingyi Fei, Jennifer A. Doudna, Taekjip Ha   +4 more
openalex   +1 more source

Efficient multiplexed genome engineering with a polycistronic tRNA and CRISPR guide-RNA reveals an important role of detonator in reproduction of Drosophila melanogaster

, 2021
Cristin Chon, Grace Chon, Yurika Matsui, Huiqing Zeng, Zhi-Chun Lai, Aimin Liu   +5 more
openalex   +2 more sources

Improved guide RNA design [PDF]

Nature Methods, 2014
openaire   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Proximity-activated guide RNA of CRISPR-Cas12a for programmable diagnostic detection and gene regulation. [PDF]

Nucleic Acids Res
Hu Z, Ling S, Duan J, Yu Z, Che Y, Wang S, Zhang S, Zhang X, Li Z.   +8 more
europepmc   +1 more source

Assembly ofFrancisella novicidaCpf1 endonuclease in complex with guide RNA and target DNA [PDF]

, 2017
Pablo Alcón, Guillermo Montoya, Stefano Stella   +2 more
openalex   +1 more source