Results 271 to 280 of about 4,450,920 (398)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Blood-feeding adaptations and virome assessment of the poultry red mite Dermanyssus gallinae guided by RNA-seq

, 2023
José M. C. Ribeiro, David J. Hartmann, Pavla Bartošová‐Sojková, Humberto Debat, Martin Moos, Petr Šimek, Jiří Fara, Martin Palus, Matěj Kučera, Ondřej Hajdušek, Daniel Sojka, Petr Kopáček, Jan Perner   +12 more
openalex   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

PathoGD: an integrative genomics approach to primer and guide RNA design for CRISPR-based diagnostics. [PDF]

Commun Biol
Low SJ, O'Neill M, Kerry WJ, Wild N, Krysiak M, Nong Y, Azzato F, Hor E, Williams L, Taiaroa G, Steinig E, Pasricha S, Williamson DA.   +12 more
europepmc   +1 more source

RNA modifications and structures cooperate to guide RNA–protein interactions

Nature reviews. Molecular cell biology, 2017
Cole J.T. Lewis, T. Pan, Auinash Kalsotra   +2 more
semanticscholar   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, EarlyView.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

Ion Mobility Gas-Phase Separation Enhances Top-Down Mass Spectrometry of Heavily Modified Guide RNA. [PDF]

Anal Chem
Macias LA, Lowther J, Tillotson EL, Rohde E, Madsen JA.   +4 more
europepmc   +1 more source

Structural and Dynamic Impacts of Single-atom Disruptions to Guide RNA Interactions within the Recognition Lobe of Geobacillus stearothermophilus Cas9 [PDF]

Helen B Belato, Andrew W. Knight, Alexandra M. D’Ordine, Chinmai Pindi, Zhi-Qiang Fan, Jinping Luo, Giulia Palermo, G. Jogl, George P. Lisi   +8 more
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Conformational transitions of Streptococcus pyogenes Cas9 induced by salt and single-guide RNA binding. [PDF]

J Biol Chem
He Y, Zalenski N, Stephenson AA, Raper AT, Ghimire C, Suo Z.   +5 more
europepmc   +1 more source