Results 281 to 290 of about 570,529 (349)

Impact of RNA-Guided Technologies for Target Identification and Deconvolution [PDF]

, 2014
Myles Fennell, Qing Xiang, Alexia Hwang, Chong Chen, Chun‐Hao Huang, Chi-Chao Chen, Raphael Pelossof, Ralph Garippa   +7 more
openalex   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Re-engineered guide RNA enables DNA loops and contacts modulating repression in E. coli. [PDF]

Nucleic Acids Res
Yang Y, Rocamonde-Lago I, Shen B, Berzina I, Zipf J, Högberg B.   +5 more
europepmc   +1 more source

Decoding the Dynamics that Guide Selection of TAR RNA Conformation [PDF]

, 2011
Jeremy D. Kratz
openalex  

495. Adenoviral Vector Delivery of RNA-Guided CRISPR/Cas9 Nuclease Complexes Induces Targeted Mutagenesis in a Diverse Array of Human Cells [PDF]

, 2014

openalex   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Direct delivery of Cas9 or base editor protein and guide RNA complex enables genome editing in the retina. [PDF]

Mol Ther Nucleic Acids
Pulman J, Botto C, Malki H, Ren D, Oudin P, De Cian A, As M, Izabelle C, Saubamea B, Forster V, Fouquet S, Robert C, Portal C, El-Amraoui A, Fisson S, Concordet JP, Dalkara D.   +16 more
europepmc   +1 more source

Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

, 2013
Kevin M. Esvelt, Prashant Mali, Jonathan L. Braff, Mark Moosburner, Stephanie J. Yaung, George M. Church   +5 more
openalex   +2 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Cas9/guide RNA-based gene-drive dynamics following introduction and introgression into diverse anopheline mosquito genetic backgrounds. [PDF]

BMC Genomics
Tushar T, Pham TB, Parker K, Crepeau M, Lanzaro GC, James AA, Carballar-Lejarazú R.   +6 more
europepmc   +1 more source