Results 91 to 100 of about 1,518,022 (349)

Optimizing Guideline-Recommended Antibiotic Doses for Pediatric Infective Endocarditis [PDF]

, 2016
The American Heart Association recently published an updated scientific statement on the management of infective endocarditis in childhood. The recommendations included for vancomycin, aminoglycoside, and β-lactam dosing and monitoring are based ...
Israel, Emily N., Knoderer, Chad A., Nichols, Kristen R., Thomas, Christopher A.   +3 more
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

ITE guideline for teacher educators in inquiry-based science teaching [PDF]

, 2009
This guideline for teacher educators and their students offers a set of arguments in favour of developing opportunities for more opene ended or investigative type work in science ...
McNally, Jim
core  

How should we evaluate research on counselling and the treatment of depression? A case study on how NICE’s draft 2018 guideline considered what counts as best evidence [PDF]

, 2017
Background: Health guidelines are developed to improve patient care by ensuring the most recent and “best available evidence” is used to guide treatment recommendations (NICE Guidance, 2017).
Barber, Barkham, Barkham, Barkham, Barnes, Barth, Beattie, Beck, Bedi, Binder, Cape, Cartwright, Clark, Clarke, Cohen, Cuijpers, Cuijpers, Cuijpers, Cuijpers, Emslie, Evans, Goldman, Greenberg, Gyani, Gyani, Hernandez-Villafuerte, Hill, Hussain-Gambles, Jadad, Kanters, Kaufman, Kazdin, Kennedy-Martin, King, Kroenke, Lawrence, Lawrence, Levitt, Lillevoll, Lindhiem, London School of Economics and Political Science. Centre for Economic Performance. Mental Health Policy Group, Mason, McLeod, Midgley, Mills, Moriana, Mundt, Nilsson, Perren, Pybis, Radhakrishnan, Rawlins, Ridge, Roth, Sanders, Saxon, Saxon, Saxon, Simpson, Smith, Spitzer, Stiles, Stiles, Stoppard, Straarup, Stronks, Stuart, Timulak, Valkonen, Vlayen, Wald, Ward, Watson, Wessley, Williams   +74 more
core   +2 more sources

Guideline Adherence and Registry Recruitment of Congenital Primary Hypothyroidism: Data from the German Registry for Congenital Hypothyroidism (HypoDok) [PDF]

, 2021
Julia Thomann, Sascha R. Tittel, Egbert Voß, Rudolf Oeverink, Katja Palm, Susanne Fricke‐Otto, Klaus Kapelari, Reinhard W. Holl, Joachim Woelfle, Markus Bettendorf   +9 more
openalex   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Application of 2015 American Gastroenterological Association Guidelines On a Retrospective Cohort of Patients with Asymptomatic Pancreatic Cysts: Can We Truly Forego Endoscopic Ultrasound?

Journal of Digestive Endoscopy, 2018
Objective: Asymptomatic pancreatic cysts are frequently diagnosed on cross-sectional imaging. Recently, the American Gastroenterological Association (AGA) has put forth guidelines regarding management of these cysts.
Krishnan Kumar, Omer Anam, Raza Ali, Miller A Ross, Mody R Dina, Krishnan Kumar   +5 more
doaj   +1 more source

Assessing Consistency and Fairness in Sentencing: A Comparative Study in Three States [PDF]

, 2008
Summarizes a study of sentencing guidelines in Michigan, Minnesota, and Virginia comparing levels of predictability and judicial discretion under different guideline systems, effectiveness in limiting discriminatory disparities, and lessons ...
Brian J. Ostrom, Charles W. Ostrom, Matthew Kleiman, Roger A. Hanson   +3 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source