Results 101 to 110 of about 717,865 (247)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Guideline-based cardiovascular disease risk assessment among Indigenous Australians in a general practice setting

, 2021
Guideline-based cardiovascular disease risk assessment among Indigenous Australians in a general practice ...
Maureen Turner (17175892), Aneta Kotevski (369002), Karen Lamb (3558776), Tanya Druce (8387355), Julie Simpson (3452045), Luke Burchill (10683879), Gabrielle Ebsworth (17175895), Ping-Wen Lee (17175886), Javier Haurat (17175889), Karen Bryant (17175898), Digsu Koye (5516330), Eloise Price (17175901), Georgia Taylor (3491633)   +12 more
core  

Final Year Project Guideline

, 2020
The final year project (FYP) is one of the core program subjects in the Bachelor of Project Management (Hons) and Bachelor of Industrial Technology Management (Hons), which is intended to expose the students to the process of conducting academic research
Nawanir, Gusman, Lee, Chia Kuang, Mahmud, Fatimah   +2 more
core   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Diagnosis and staging of patients with ovarian cancer: National Clinical Guideline No. 20

, 2019
This guideline is intended for all health professionals involved in the diagnosis and staging of patients with ovarian cancer and health professionals working in Genetics Services.
Department of Health
core  

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Use of Intravenous Albumin:A Guideline From the International Collaboration for Transfusion Medicine Guidelines [PDF]

Background: Albumin is used commonly across a wide range of clinical settings to improve hemodynamics, to facilitate fluid removal, and to manage complications of cirrhosis.
Clark, Edward G., Paine, Cary, Bathla, Aarti, Wu, Bovey, Thevenot, Thierry, Clark, Edward G, Jug, Rachel, China, Louise, Szczepiorkowski, Zbigniew M, Skubas, Nikolaos J., Shah, Prakesh S., Szczepiorkowski, Zbigniew M., Arbous, Sesmu, Shah, Prakesh S, Bauer, Seth R, Skubas, Nikolaos J, Pavenski, Katerina, Shan, Hua, Stanworth, Simon, Callum, Jeannie, Shehata, Nadine, Keshavarz, Homa, Rochwerg, Bram, Fung, Mark, Bauer, Seth R., Neill, Michael, Fergusson, Dean, Robinson, Susan   +27 more
core   +1 more source