Results 81 to 90 of about 1,518,022 (349)
Clinical neurorestorative therapeutic guideline for brainstem hemorrhage (2020 China version)
Journal of Neurorestoratology, 2020 Brainstem hemorrhage (mainly pontine hemorrhage caused by hypertension) has the clinical characteristics of acute onset, rapid progress, high mortality, and high disability rate.
Lin Chen +18 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Teardown analysis for detecting shelf-life degradation [PDF]
, 1971 Analysis is guideline in examining component materials, analytically determining physical properties and chemical compositions, and developing control data necessary for ascertaining effects of environments and their influence on deterioration and ...
Eckstein, A. S.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Improvement of Lupus and Sjögren’s Syndrome Symptoms by Acupuncture Treatment: A Case Report
Journal of Acupuncture ResearchThe present study aimed to report the case of a patient with systemic lupus erythematosus and Sjögren’s syndrome who was successfully treated with Korean medicine.
Ju-Hyun Lee +4 more
doaj +1 more source
GRADE equity guidelines 4: guidance on how to assess and address health equity within the evidence to decision process [PDF]
, 2017 Objective: The aim of this paper is to provide detailed guidance on how to incorporate health equity within the GRADE (Grading Recommendations Assessment and Development Evidence) evidence to decision process.
Akl, Elie A +19 more
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Frontiers in Public HealthIntroductionPublic health emergency preparedness requires capacities and capabilities to respond to a diverse range of health threats. A key objective of Ireland’s recent Health Protection Strategy is to enable preparedness, prevention, early detection ...
Louise Marron +5 more
doaj +1 more source