Results 71 to 80 of about 480,404 (283)
Clinical Practice Guideline on management of older patients with chronic kidney disease stage 3b or higher (eGFR<45 mL/min/1.73 m2): a summary document from the European Renal Best Practice Group [PDF]
, 2017 Ken Farrington, Adrian Covic, Ionuţ Nistor, Filippo Aucella, Naomi Clyne, Leen De Vos, Andrew R. Findlay, Denis Fouque, Tomasz Grodzicki, Osasuyi Iyasere, Kitty J. Jager, Hanneke Joosten, Juan F. Macías Núñez, Andrew Mooney, Evi Nagler, Dorothea Nitsch, Maarten W. Taal, James Tattersall, Marijke Stryckers, Dieneke van Asselt, Nele Van Den Noortgate, Sabine N van der Veer, Wim Van Biesen +22 moreopenalex +1 more sourceLINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico +12 morewiley +1 more sourceATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs +11 morewiley +1 more sourcePreliminary Evaluation of the Scandinavian Guidelines for Initial Management of Minimal, Mild, and Moderate Head Injuries with Glial Fibrillary Acidic Protein
Neurotrauma ReportsGlial fibrillary acidic protein (GFAP) has become the most promising biomarker for detecting traumatic abnormalities on head computed tomography (CT) in patients with traumatic brain injury (TBI), but most studies have not addressed the potential added ...Mira Keski-Pukkila, Justin E. Karr, Jussi P. Posti, Ksenia Berghem, Anna-Kerttu Kotilainen, Kaj Blennow, Henrik Zetterberg, Grant L. Iverson, Teemu M. Luoto +8 moredoaj +1 more sourceEPI-Net One Health reporting guideline for antimicrobial consumption and resistance surveillance data: a Delphi approach
, 2022 Nithya Rajendran, Fabiana Arieti, Carla Alejandra Mena-Benítez, Liliana Galia, Maela Tebon, Julio Álvarez, Beryl Primrose Gladstone, Lucie Collineau, Giulia De Angelis, Raquel Duro, William H. Gaze, Siri Göpel, Souha S. Kanj, Annemarie Käsbohrer, Direk Limmathurotsakul, Estibaliz Lopez de Abechuco, Elena Mazzolini, Nico T. Mutters, Maria Diletta Pezzani, Elisabeth Presterl, Hanna Renk, Jesús Rodríguez‐Baño, Oana Săndulescu, Federico Scali, Robert Skov, Thirumalaisamy P. Velavan, Cuong Vuong, Evelina Tacconelli, Ayôla Akim Adégnika, Lisa Avery, Marc J. M. Bonten, Alessandro Cassini, Claire Chauvin, Monica Compri, Peter Damborg, Sabine De Greeff, María Dolores del Toro, Matthias Filter, Alison M. Franklin, Bruno González‐Zorn, Kari Grave, Didier Hocquet, Ludwig E. Hoelzle, Erta Kalanxhi, Ramanan Laxminarayan, Leonard Leibovici, Surbhi Malhotra‐Kumar, Marc Mendelson, Mical Paul, Cristina Muñoz Madero, Rita Murri, Laura J. V. Piddock, Carolien Ruesen, Maurizio Sanguinetti, T. Schilling, Remco Schrijver, Mitchell J. Schwaber, Luigia Scudeller, Didem Törümküney, Thomas P. Van Boeckel, Wannes Vanderhaeghen, Andreas Voß, Teresa M. Wozniak +62 moreopenalex +1 more sourceDeveloping evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking +43 morewiley +1 more sourceInternational Digestive Endoscopy Network consensus on the management of antithrombotic agents in patients undergoing gastrointestinal endoscopy [PDF]
Clinical EndoscopyAntithrombotic agents, including antiplatelet agents and anticoagulants, are widely used in Korea because of the increasing incidence of cardiocerebrovascular disease and the aging population. The management of patients using antithrombotic agents during Seung Joo Kang, Chung Hyun Tae, Chang Seok Bang, Cheol Min Shin, Young-Hoon Jeong, Miyoung Choi, Joo Ha Hwang, Yutaka Saito, Philip Wai Yan Chiu, Rungsun Rerknimitr, Christopher Khor, Vu Van Khien, Kee Don Choi, Ki-Nam Shim, Geun Am Song, Oh Young Lee, +16 moredoaj +1 more sourceTherapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida +10 morewiley +1 more source
