Results 91 to 100 of about 16,189,469 (293)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Best practices for the collection and analysis of patient experience data from social media for patient-focused drug development

Frontiers in Medicine
Patient experience data derived from social media captures the unsolicited conversations of patients and helps in understanding their subjective experiences with disease and treatments.
Philipp Cimiano, Philipp Cimiano, Nicole Brazda, Matthias Hartung, Cornelius Starke-Knäusel, Ana Lucia Schmidt, Maria Carmela De Vuono, Aditya Tyagi, Jürgen Gottowik, Raul Rodriguez-Esteban, Ben Collins, Krzysztof Wieckowski, Thierry Escudier   +12 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

How to Integrate Multiple Comorbidities in Guideline Development: Article 10 in Integrating and Coordinating Efforts in COPD Guideline Development. An Official ATS/ERS Workshop Report.

, 2012
Background: Professional societies, like many other organizations around the world, have recognized the need to use more rigorous processes to ensure that health care recommendations are informed by the best available research evidence.
Rabe KF, Fabbri LM, Schünemann HJ, Coordinating Efforts in COPD Guideline Development, Leff B, Buist AS, on behalf of the ATS/ERS Ad Hoc Committee on Integrating, Kent DM, Yawn B, BOSCHETTO, Piera, Boyd C   +10 more
core  

The Innovative Potential of Artificial Intelligence Applied to Patient Registries to Implement Clinical Guidelines

Machine Learning and Knowledge Extraction
Guidelines provide specific recommendations based on the best available medical knowledge, summarizing and balancing the advantages and disadvantages of various diagnostic and treatment options.
Sebastiano Gangemi, Alessandro Allegra, Mario Di Gioacchino, Luca Gammeri, Irene Cacciola, Giorgio Walter Canonica   +5 more
doaj   +1 more source

Development of departmental promotion guidelines

Academic Medicine, 1979
In making optimum use of its faculty, a medical school department should ensure that each faculty member has a clear understanding of what is expected of him and what will be evaluated when he is considered for reappointment or promotion. A set of departmental promotion guidelines which are available to all faculty can serve both these ends.
J H, Spencer, J F, Crow, R, Glass
openaire   +3 more sources

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

ESHRE guideline : number of embryos to transfer during IVF/ICSI

STUDY QUESTION: Which clinical and embryological factors should be considered to apply double embryo transfer (DET) instead of elective single embryo transfer (eSET)?
McHeik, Saria, ESHRE Guideline Group on the Number of Embryos to Transfer, Baccino, Giuliana, Arroyo, Gemma, Alteri, Alessandra, Veleva, Zdravka   +5 more
core   +1 more source

IDB Newsletter: Vol. 6, no. 3, July 1968

, 1968
IDB Newsletter is a monthly publication of the Inter-American Development that reports on the activities of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core   +1 more source