Results 81 to 90 of about 16,189,469 (293)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Methods for guideline development [PDF]

Kidney International Supplements, 2012
  +9 more sources

From Preservation to Precision in Pediatric Dentistry: Evidence-Calibrated Viewpoint and Heuristic Framework for Silver Diamine Fluoride Guidance

Children
Silver diamine fluoride (SDF) is a key preservation-based intervention in pediatric dentistry. It can arrest many cavitated lesions, reduce treatment burden, and expand access for children who cannot receive conventional restorative care.
Ziad D. Baghdadi
doaj   +1 more source

Prioritizing WHO normative work on maternal and perinatal health: a multicountry survey

Reproductive Health, 2011
Background WHO develops evidence-based guidelines for setting global standards and providing technical support to its Member States and the international community, as a whole.
Coltart Cordelia EM, Souza João, Gülmezoglu Ahmet M   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Telecommunication Sector Policies for the Development of Information and Communication Technologies in Panama: Part I

, 2018
This document is the first of a two-volume study that provides a policy guideline that draws conclusions from international experience and economic analysis to recommend some policies that are expected to foster the development of ICTs in Panama, as well
Inter-American Development Bank
core   +1 more source

Improving the Applicability and Feasibility of Clinical Practice Guidelines in Primary Care: Recommendations for Guideline Development and Implementation

Risk Management and Healthcare Policy, 2021
Lu Han,1,2 Linan Zeng,1,2 Yanjun Duan,3 Kexin Chen,4 Jiajie Yu,5 Honghao Li,6 Qiusha Yi,1,2 Youping Li,5 Lingli Zhang1,2 1Department of Pharmacy/Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, Sichuan ...
Han L, Zeng L, Duan Y, Chen K, Yu J, Li H, Yi Q, Li Y, Zhang L   +8 more
doaj  

Common issues raised during the quality assurance process of WHO guidelines: a cross-sectional study

Health Research Policy and Systems, 2018
Background In 2007, WHO established the Guidelines Review Committee (GRC) to ensure that WHO guidelines adhere to the highest international standards. The GRC reviews guideline proposals and final guidelines.
Teegwendé V. Porgo, Mauricio Ferri, Susan L. Norris   +2 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Qualitative Evidence Synthesis (QES) for Guidelines: Paper 2 – Using qualitative evidence synthesis findings to inform evidence-to-decision frameworks and recommendations

Health Research Policy and Systems, 2019
Background WHO has recognised the need to improve its guideline methodology to ensure that guideline decision-making processes are transparent and evidence based, and that the resulting recommendations are relevant and applicable.
Simon Lewin, Claire Glenton, Theresa A. Lawrie, Soo Downe, Kenneth W. Finlayson, Sarah Rosenbaum, María Barreix, Özge Tunçalp   +7 more
doaj   +1 more source