Results 141 to 150 of about 4,454,225 (289)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Anti-Viral Treatment Eligibility and Treatment Uptake Among People With Chronic Hepatitis B in Australia: The REACH-B Study. [PDF]

J Viral Hepat
Hajarizadeh B, Nelson R, George J, Hanson J, Davies J, Martinello M, Brown T, Wong I, Hasan T, Mascarenhas L, O'Beirne J, Wade A, Capati M, Trotter G, Thomas S, Nash L, Cowie B, Allard N, Tu T, Tran L, Howard S, Monaghan R, Carter J, Tu E, Erratt A, Carson J, Dore GJ, Matthews GV, REACH‐B Study Group.   +28 more
europepmc   +1 more source

Clinical Guidelines for Localised Musculoskeletal Foot Pain: A Podiatry Perspective

, 2013
This book includes an overview of the importance of clinical guidelines for a number of foot conditions, the systematic review methodology employed to investigate existing guidelines, and the appraisal processes to develop a summary of recommendations ...
Du Toit, Verona (R12026), Bialocerkowski, Andrea (R14273)   +1 more
core  

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Challenges and recommendations for implementation of oncology clinical practice guidelines in China. [PDF]

PLoS Med
Lv M, Yuan D, Suo Y, Ding F, Hu L, Cao L, Wang Y, Lei J, Tang S, Liu T.   +9 more
europepmc   +1 more source

Guidelines are merely guidelines

Indian Journal of Psychiatry
Chittaranjan Andrade, Sujit Sarkhel
openaire   +3 more sources

Development document for proposed effluent limitations guidelines, new source performance standards, and pretreatment standards for the textile mills point source category.

, 1979
Oct. 1979.Cover title: Development document for effluent limitations guidelines and standards for the textile mills point source category.Bibliography: p.
United States. Environmental Protection Agency. Effluent Guidelines Division.
core  

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

When Guidelines Are Not Enough: Clinician Hesitation to Diagnose Borderline Personality Disorder in Adolescents as a Barrier to Timely Evidence-Based Care. [PDF]

Personal Ment Health
Shahbaz S.
europepmc   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source