Results 61 to 70 of about 7,672,395 (400)

Management of the ataxias : towards best clinical practice [PDF]

, 2016
This document aims to provide recommendations for healthcare professionals on the diagnosis and management of people with progressive ataxia. The progressive ataxias are rare neurological conditions, and are often poorly understood by healthcare ...
Bates, Claire, Baxter, Peter, Bonney, Harriet, Bremner, Fion, Bunn, Lisa, Carrillo Perez-Tome, Maria, Chung, Mark, Cipolotti, Lisa, de Silva, Rajith, Duberley, Kate, Ealing, John, Emmanuel, Anton, Giunti, Paola, Greenfield, Julie, Hadjivassilliou, Marios, Harshavardhana, N.S., Hayward, Kate, Hendriksz, Christian, Hersheson, Joshua, Horvath, Rita, Hurford, Joanne, Jaffer, Fatima, Kilbride, Cherry, Lowit, Anja, Marsden, Jonathan, Nemeth, Andrea, Noordeen, M H Hilali, Panicker, Jalesh, Pantazis, Antonios, Parkinson, Michael H, Redmond, Liz, Uus, Kai   +31 more
core   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

GoLLIE: Annotation Guidelines improve Zero-Shot Information-Extraction [PDF]

arXiv, 2023
Large Language Models (LLMs) combined with instruction tuning have made significant progress when generalizing to unseen tasks. However, they have been less successful in Information Extraction (IE), lagging behind task-specific models. Typically, IE tasks are characterized by complex annotation guidelines that describe the task and give examples to ...
arxiv  

Lupus nephritis management guidelines compared [PDF]

, 2015
In the past years, many (randomized) trials have been performed comparing the treatment strategies for lupus nephritis. In 2012, these data were incorporated in six different guidelines for treating lupus nephritis.
Bajema, IM, Bertsias, GK, Boumpas, DT, Gordon, C, Jayne, DR, Lightstone, L, Tesar, V, Wilhelmus, S   +7 more
core   +1 more source

Subpar reporting of pre‐analytical variables in RNA‐focused blood plasma studies

Molecular Oncology, EarlyView.
Pre‐analytical variables strongly influence the analysis of extracellular RNA (cell‐free RNA; exRNA) derived from blood plasma. Their reporting is essential to allow interpretation and replication of results. By evaluating 200 exRNA studies, we pinpoint a lack of reporting pre‐analytical variables associated with blood collection, plasma preparation ...
Céleste Van Der Schueren, Philippe Decruyenaere, Francisco Avila Cobos, Johanna Bult, Jill Deleu, Laudonia Lidia Dipalo, Hetty Hilde Helsmoortel, Eva Hulstaert, Annelien Morlion, Elena Ramos Varas, Kathleen Schoofs, Wim Trypsteen, Eveline Vanden Eynde, Hanne Van Droogenbroeck, Kimberly Verniers, Jo Vandesompele, Anneleen Decock   +16 more
wiley   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

WAccess -- A Web Accessibility Tool based on WCAG 2.2, 2.1 and 2.0 Guidelines [PDF]

arXiv, 2021
The vision of providing access to all web content equally for all users makes web accessibility a fundamental goal of today's internet. Web accessibility is the practice of removing barriers from websites that could hinder functionality for users with various disabilities. Web accessibility is measured against the accessibility guidelines such as WCAG,
arxiv  

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source

A Semi-automated Method for Domain-Specific Ontology Creation from Medical Guidelines [PDF]

arXiv, 2021
The automated capturing and summarization of medical consultations has the potential to reduce the administrative burden in healthcare. Consultations are structured conversations that broadly follow a guideline with a systematic examination of predefined observations and symptoms to diagnose and treat well-defined medical conditions. A key component in
arxiv