Results 71 to 80 of about 4,330,253 (294)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

AAD Guidelines- Focused Update: Guidelines of care for the management of atopic dermatitis in adults

Background: In 2023 and 2024, the AAD published guidelines on the use of topical and systemic therapies for the management of atopic dermatitis (AD) in adults.
Guidelines, AAD
core   +1 more source

Hernia rationing: an assessment of commissioning guidelines

, 2021
Introduction Hernias are a common surgical condition. Most guidelines recommend repair in almost all cases. NHS Devon clinical commissioning group (CCG) guidelines restrict the commissioning of hernia repair.
W Gewanter, Gewanter, W, Hubbard, T, Ferguson, D, T Hubbard, D Ferguson   +5 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Withholding Cardiopulmonary Resuscitation: Proposals for Formal Guidelines

, 1993
Working with members of the Royal London Trust and its medical council, Len Doyal and Daniel Wilsher have composed a set of guidelines governing the making of decisions to withhold resuscitation from patients.
Doyal, Len, Wilsher, Daniel
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Editor's Choice -- European Society for Vascular Surgery (ESVS) 2025 Clinical Practice Guidelines on the Management of Vascular Trauma

OBJECTIVE: The European Society for Vascular Surgery (ESVS) has developed clinical practice guidelines for the care of patients with vascular trauma with the aim of assisting physicians in selecting the optimal management strategy.METHODS: The guidelines
Dubose, Joseph J.,, Vega de Ceniga, Melina, Boyle, Jonathan R.,, Ruffino, M.A., Blair, Paul,, de Ceniga, Melina Vega,, Van Herzeele, Isabelle,, Kakkos, Stavros K, Civil, Ian D.S., Jongkind, V., Piffaretti, G., ESVS Guidelines Committee, [missing], Wahlgren, Carl Magnus,, DuBose, Joseph J, Twine, Christopher P.,, Van Herzeele, Isabelle, Boyle, Jonathan R., DuBose, J.J., Heim, C., Wahlgren, C.M., Mitchell, Erica L, Piffaretti, Gabriele,, Wanhainen, Anders,, Wipper, S., Mees, BME, Antoniou, George A., Trimarchi, Santi,, Wipper, Sabine, Dias, N.V., Engelhardt, Michael,, Coscas, Raphael,, Aylwin, C., Mitchell, E.L., Jorgensen, Joakim, Boyle, Jonathan R, Gaarder, C., Dubose, Joseph J., Civil, Ian D. S.,, Wipper, Sabine,, Kakkos, S.K., Dias, Nuno V., Civil, Ian D. S., Ruffino, Maria Antonella, Wanhainen, A., Vikatmaa, Pirkka, Mees, Barend M.E., Mees, Barend M. E.,, Aylwin, Christopher, Ruffino, Maria Antonella,, Ricco, Jean-Baptiste,, de Ceniga, Melina Vega, Kakkos, Stavros K.,, Twine, Christopher P, Mees, Barend M. E., Dias, Nuno, V, Vikatmaa, P., Antoniou, G.A., Brohi, Karim, Coscas, Raphaël, Civil, Ian D S, Davenport, Ross A, Heim, Catherine, Blair, P., Engelhardt, M., Coscas, R., Heim, Catherine,, Davidovic, Lazar B, Wanhainen, Anders, Trimarchi, Santi, Dias, Nuno, V,, Ricco, J.B., ?, ?, Mcgreevy, David T., Gaarder, Christine,, Davenport, Ross A.,, Jongkind, Vincent,, Antoniou, George A.,, Davenport, R.A., Twine, C.P., Piffaretti, Gabriele, Wahlgren, Carl Magnus, Trimarchi, S., McGreevy, David T, Blair, Paul, Antoniou, George A, Vega de Ceniga, M., Davenport, Ross A., Jorgensen, Joakim,, McGreevy, D.T., Aylwin, Christopher,, Van Herzeele, I., JørgensenIn, Joakim, Mees, Barend M E, Davidovic, Lazar B.,, Twine, Christopher P., Jongkind, Vincent, Dias, Nuno V, Ricco, Jean-Baptiste, Mitchell, Erica L.,, Brohi, K., Davidovic, Lazar B., Vikatmaa, Pirkka,, Boyle, J.R., Engelhardt, Michael, Mitchell, Erica L., Jørgensen, J., Mcgreevy, David T.,, Gaarder, Christine, Brohi, Karim,, Kakkos, Stavros K., ESVS Guidelines Committee, George A., Davidovic, L.B., Civil, IDS, Dias, Nuno, Jørgensen, Joakim   +114 more
core   +1 more source

General Statement of Ethical Principles and Guidelines

, 2010
ACHA recognizes that these guidelines are a work in progress and will change as law and professional standards in the field of college health evolve. At this time, ACHA expects that all members actively uphold the principles and guidelines detailed in ...

core   +1 more source

COVID-19 Treatment Guidelines

, 2022
The COVID-19 Treatment Guidelines provide clinicians with evidence-based recommendations on the management of COVID ...
Hinkson, Carl R, COVID-19 Treatment Guidelines Panel Members,   +1 more
core   +1 more source

Which Measure of Stone Burden is the Best Predictor of Interventional Outcomes in Urolithiasis: A Systematic Review and Meta-analysis by the YAU Urolithiasis Working Group and EAU Urolithiasis Guidelines Panel

European Urology Open Science
Background and objective: Stone size has traditionally been measured in one dimension. This is reflected in most of the literature and in the EAU guidelines.
Robert Geraghty, Amelia Pietropaolo, Lazaros Tzelves, Riccardo Lombardo, Helene Jung, Andreas Neisius, Ales Petrik, Bhaskar K. Somani, Niall F. Davis, Giovanni Gambaro, Romain Boissier, Andreas Skolarikos, Thomas Tailly   +12 more
doaj   +1 more source