Results 91 to 100 of about 3,793,883 (300)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

RDM-guidelines

<h2>What's Changed</h2> <ul> <li>247 assess and improve accessibility by @YvonneKallberg in https://github.com/ScilifelabDataCentre/RDM-guidelines/pull/345</li> <li>Use official base images by @senthil10 in https ...
Asklof, Anna, Hughes, Liane, Jareborg, Niclas, Kronander, Elin, Kallberg, Yvonne, Englund, Markus, Stark, Katarina Öjefors, Kultima, Hanna   +7 more
core   +2 more sources

Guidelines, guidelines, guidelines! [PDF]

Post Reproductive Health, 2016
Heather, Currie, Eddie, Morris, Paul, Simpson   +2 more
openaire   +2 more sources

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Measuring the Quality of Evidence-Based Nursing Care: NQuIRE - Nursing Quality Indicators for Reporting and Evaluation Data-System / Midiendo la calidad del cuidado de Enfermería basado en la evidencia: NQuIRE – Sistema de Indicadores de Calidad en Enfermería para reportar y evaluar / Avaliando a qualidade dos cuidados de enfermagem baseada em evidências: NQuIRE – Sistema de Indicadores de Qualidade na Enfermagem para Referenciar e Avaliar

MedUNAB, 2015
Introducción: El sistema de indicadores de calidad en enfermería para reportar y evaluar (NQuIRE) es una iniciativa internacional de mejoramiento de la calidad para desarrollar y sostener un sistema de datos de indicadores de calidad de enfermería ...
Doris Grinspun, RN., MSN., PhD., LLD (Hon)., O.ONT., Monique Lloyd, RN., PhD. , Sarah Xiao, RN., MsCN. , Irmajean Bajnok, RN., MScN., PhD.   +3 more
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Guidelines for Conducting Joint Evaluations of Humanitarian Action

, 2011
A joint evaluation is when different agencies work together to evaluate and review their response to an emergency. This helps agencies increase accountability and transparency, to learn from one another, and to coordinate future responses.

core  

Primary cutaneous lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

, 2013
No abstract ...
Ladetto M, ESMO Guidelines Working Group, Hodak E, Specht L, ZINZANI, PIER LUIGI, Willemze R   +5 more
core   +1 more source

Author Guidelines

African Journal of Information & Communication Technology, 2006
This document guides would be authors of papers for review in the AJICT on how to write their papers to meet the requirements for submissions, reviews and publications in the ...
openaire   +18 more sources